2016
FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
Dover K, Marra C, Solinas S, Popovic M, Subramaniyam S, Zecevic D, D’Angelo E, Goldfarb M. FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon. Nature Communications 2016, 7: 12895. PMID: 27666389, PMCID: PMC5052690, DOI: 10.1038/ncomms12895.Peer-Reviewed Original ResearchCentral nervous systemAction potentialsNervous systemSodium action potentialsGranule cell axonsAxon initial segmentCerebellar granule cellsNodes of RanvierCell axonsSomatodendritic membraneVertebrate central nervous systemGranule cellsCerebellar granule cell axonsDistal axonsSpike conductionAxonsSodium channels
2011
Somatic Membrane Potential and Kv1 Channels Control Spike Repolarization in Cortical Axon Collaterals and Presynaptic Boutons
Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA. Somatic Membrane Potential and Kv1 Channels Control Spike Repolarization in Cortical Axon Collaterals and Presynaptic Boutons. Journal Of Neuroscience 2011, 31: 15490-15498. PMID: 22031895, PMCID: PMC3225031, DOI: 10.1523/jneurosci.2752-11.2011.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsAxonsBiophysical PhenomenaComputer SimulationCrystallinsDose-Response Relationship, DrugElapid VenomsElectric StimulationFemaleGreen Fluorescent ProteinsIn Vitro TechniquesMaleMembrane PotentialsMiceMice, TransgenicModels, NeurologicalMu-CrystallinsNerve NetNeuronsPatch-Clamp TechniquesPotassium Channel BlockersPresynaptic TerminalsShaker Superfamily of Potassium ChannelsSomatosensory CortexStyrenesTetraethylammoniumConceptsAxon collateralsPresynaptic boutonsKv1 channelsSpike repolarizationPresynaptic terminalsSubthreshold depolarizationAction potentialsΑ-dendrotoxinLayer 5 pyramidal cellsIntracortical axon collateralsSynaptic neurotransmitter releaseMouse brain slicesSomatic membrane potentialKv1 subunitsPyramidal cellsSynaptic transmissionBrain slicesVoltage-sensitive dyeLow dosesNeurotransmitter releaseSynaptic strengthBoutonsCollateralsRepolarizationIon channelsThe spatio‐temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging study
Popovic MA, Foust AJ, McCormick DA, Zecevic D. The spatio‐temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging study. The Journal Of Physiology 2011, 589: 4167-4187. PMID: 21669974, PMCID: PMC3180577, DOI: 10.1113/jphysiol.2011.209015.Peer-Reviewed Original ResearchConceptsSpike trigger zoneAction potential initiationAxon initial segmentTrigger zoneLayer 5 pyramidal neuronsPotential initiationLayer 5 pyramidal cellsMature axonsPyramidal neuronsAxonal collateralsPyramidal cellsNeuronal plasticityAction potentialsImmature axonsPotential imaging techniqueAxonsImmunocytochemical dataNeuronal computationSaltatory conductionAP propagationElectrophysiological measuresInitial segmentImaging techniquesCritical roleInitiation
2010
Action Potentials Initiate in the Axon Initial Segment and Propagate through Axon Collaterals Reliably in Cerebellar Purkinje Neurons
Foust A, Popovic M, Zecevic D, McCormick DA. Action Potentials Initiate in the Axon Initial Segment and Propagate through Axon Collaterals Reliably in Cerebellar Purkinje Neurons. Journal Of Neuroscience 2010, 30: 6891-6902. PMID: 20484631, PMCID: PMC2990270, DOI: 10.1523/jneurosci.0552-10.2010.Peer-Reviewed Original ResearchConceptsAxon initial segmentAxon collateralsAction potentialsPurkinje neuronsComplex spikesLocal axon collateralsCerebellar Purkinje neuronsInitial segmentFast action potentialsAxon branch pointsSynaptic inputsVoltage-sensitive dyeCerebellar cortexNeuronal processingSpike initiationDischarge frequencySingle trialCollateralsOutput cellsNeuronsRapid time course of action potentials in spines and remote dendrites of mouse visual cortex neurons
Holthoff K, Zecevic D, Konnerth A. Rapid time course of action potentials in spines and remote dendrites of mouse visual cortex neurons. The Journal Of Physiology 2010, 588: 1085-1096. PMID: 20156851, PMCID: PMC2852997, DOI: 10.1113/jphysiol.2009.184960.Peer-Reviewed Original ResearchConceptsRapid time courseAction potentialsDendritic spinesIndividual dendritic spinesLayer 5 pyramidal neuronsTime courseTiming-dependent synaptic plasticityDendritic branchesCentral mammalian neuronsTerminal dendritic branchesVisual cortex neuronsTerminal branchesSomatic action potentialsIndividual spinesRemote dendritesPyramidal neuronsApical dendritesCortex neuronsExcitatory synapsesSupralinear integrationSynaptic inputsVoltage-sensitive dyeJuvenile miceSynaptic plasticityVisual cortex
2007
Dendritic signals from rat hippocampal CA1 pyramidal neurons during coincident pre‐ and post‐synaptic activity: a combined voltage‐ and calcium‐imaging study
Canepari M, Djurisic M, Zecevic D. Dendritic signals from rat hippocampal CA1 pyramidal neurons during coincident pre‐ and post‐synaptic activity: a combined voltage‐ and calcium‐imaging study. The Journal Of Physiology 2007, 580: 463-484. PMID: 17272348, PMCID: PMC2075540, DOI: 10.1113/jphysiol.2006.125005.Peer-Reviewed Original ResearchConceptsLong-term potentiationHippocampal CA1 pyramidal neuronsCA1 pyramidal neuronsPost-synaptic activityPyramidal neuronsRat hippocampal CA1 pyramidal neuronsActivity-dependent long-term synaptic plasticityDendritic action potentialsCalcium imaging studiesLong-term synaptic plasticityDifferent dendritic locationsDendritic signalsDendritic locationMembrane potential transientsNMDA receptorsDendritic arborsPeak amplitudeStimulation protocolSynaptic plasticityAction potentialsMembrane depolarizationDendritic regionsBaselineNeuronsInduction
2005
Imaging of Spiking and Subthreshold Activity of Mitral Cells with Voltage‐Sensitive Dyes
DJURIŠIĆ M, ZEČEVIĆ D. Imaging of Spiking and Subthreshold Activity of Mitral Cells with Voltage‐Sensitive Dyes. Annals Of The New York Academy Of Sciences 2005, 1048: 92-102. PMID: 16154924, DOI: 10.1196/annals.1342.009.Peer-Reviewed Original ResearchConceptsSpike trigger zoneMitral cellsSite of originTrigger zonePrincipal output neuronsTerminal dendritic branchesPrimary dendritesOlfactory nerve stimulationRat olfactory bulbNerve stimulationDendritic tuftsOlfactory bulbVoltage-sensitive dyeAction potentialsNeuronal processesSubthreshold activityIndividual neuronsDendritic branchesSpike initiationIntracellular dyeEPSPsOutput neuronsNeuronsDendritesCells
2004
Voltage Imaging from Dendrites of Mitral Cells: EPSP Attenuation and Spike Trigger Zones
Djurisic M, Antic S, Chen WR, Zecevic D. Voltage Imaging from Dendrites of Mitral Cells: EPSP Attenuation and Spike Trigger Zones. Journal Of Neuroscience 2004, 24: 6703-6714. PMID: 15282273, PMCID: PMC6729725, DOI: 10.1523/jneurosci.0307-04.2004.Peer-Reviewed Original ResearchConceptsSpike trigger zoneMitral cellsTrigger zoneAction potentialsPrincipal output neuronsTerminal dendritic branchesPrimary dendritesOlfactory nerve stimulationRat olfactory bulbSite of originNerve stimulationDendritic tuftsSecondary dendritesEPSP attenuationOlfactory bulbSynaptic sitesNeuronal processesIndividual neuronsDendritic branchesSpike initiationIntracellular dyeEPSPsOutput neuronsNeuronsDendrites
2000
Functional profile of the giant metacerebral neuron of Helix aspersa: temporal and spatial dynamics of electrical activity in situ
Antic S, Wuskell J, Loew L, Zecevic D. Functional profile of the giant metacerebral neuron of Helix aspersa: temporal and spatial dynamics of electrical activity in situ. The Journal Of Physiology 2000, 527: 55-69. PMID: 10944170, PMCID: PMC2270048, DOI: 10.1111/j.1469-7793.2000.00055.x.Peer-Reviewed Original ResearchConceptsTrigger zoneNeuronal processesGiant metacerebral neuronSingle neuronsMulti-site optical recordingSpike trigger zoneAction potential initiationIdentified snail neuronsMetacerebral neuronsAxonal branchesVoltage-sensitive dyeSynaptic inputsPropagation of spikesSnail neuronsAction potentialsAxonal spikesPatterns of initiationNeuronsPotential initiationSynaptic signalsIndividual neuronsElectrical activityHelix aspersaFunctional profilesInitiation
1999
Fast Optical Recordings of Membrane Potential Changes From Dendrites of Pyramidal Neurons
Antic S, Major G, Zecevic D. Fast Optical Recordings of Membrane Potential Changes From Dendrites of Pyramidal Neurons. Journal Of Neurophysiology 1999, 82: 1615-1621. PMID: 10482775, DOI: 10.1152/jn.1999.82.3.1615.Peer-Reviewed Original ResearchConceptsBasolateral dendritesApical dendritesBrain slicesVoltage-sensitive dyeNeuronal processesPyramidal neuronsMembrane potential transientsPharmacological effectsSynaptic stimulationAction potentialsInvertebrate neuronsNeuronsPatch electrodeSingle neuronsElectrical activityMembrane potential changesFast optical recordingDistal processesVertebrate neuronsOptical recordingDendritesH incubation periodStimulationApical processesRecordings
1995
Optical signals from neurons with internally applied voltage-sensitive dyes
Antic S, Zecevic D. Optical signals from neurons with internally applied voltage-sensitive dyes. Journal Of Neuroscience 1995, 15: 1392-1405. PMID: 7869106, PMCID: PMC6577832, DOI: 10.1523/jneurosci.15-02-01392.1995.Peer-Reviewed Original ResearchConceptsOptical signalVoltage-sensitive dyeSilicon photodiode arrayAxonal branchesAction potentialsIndividual neuronsOptical monitoringPresent sensitivityPhotodiode arraySite of stimulationAction potential initiationLong axonal branchesSatisfactory signalIntracellular pressure injectionSynaptic potentialsFluorescence measurementsGood signalAxonal segmentsSubthreshold potentialsExtracellular applicationCell bodiesNeuronal processesFluorescence signalElectrotonic responsesPotential initiation
1989
17 Optical Measurement of Membrane Potential in Invertebrate Ganglia and Mammalian Cortex
WU J, LONDON J, ZECEVIC D, LOEW L, ORBACH H, CATTARELLI M, COHEN L. 17 Optical Measurement of Membrane Potential in Invertebrate Ganglia and Mammalian Cortex. 1989, 329-346. DOI: 10.1016/b978-0-12-417760-4.50024-0.Peer-Reviewed Original Research
1988
Optical monitoring of activity of many neurons in invertebrate ganglia during behaviors
Wu J, London JA, Zecevic D, Höpp H, Cohen LB, Xiao C. Optical monitoring of activity of many neurons in invertebrate ganglia during behaviors. Cellular And Molecular Life Sciences 1988, 44: 369-376. PMID: 3286282, DOI: 10.1007/bf01940529.Peer-Reviewed Original Research
1983
Temperature compensation of the threshold potential for excitation of the snail bursting neuron
Zečević D, Pašić M. Temperature compensation of the threshold potential for excitation of the snail bursting neuron. Comparative Biochemistry And Physiology Part A Molecular & Integrative Physiology 1983, 76: 173-176. DOI: 10.1016/0300-9629(83)90310-9.Peer-Reviewed Original Research
1980
Temperature acclimation: effects on membrane physiology of an identified snail neuron
Zecević D, Levitan H. Temperature acclimation: effects on membrane physiology of an identified snail neuron. American Journal Of Physiology 1980, 239: c47-c57. PMID: 7435551, DOI: 10.1152/ajpcell.1980.239.3.c47.Peer-Reviewed Original ResearchConceptsElectrogenic Na-K pumpSpontaneous activityAction potentialsExcitability of neuronsIntracellular electrophysiological techniquesSpontaneous action potentialsIdentified snail neuronsNa-K pumpPCs/PKLong-term effectsIsolated ganglionSnail neuronsElectrophysiological techniquesNeuronsCompensatory changesNeuronal basisPNa/PKExcitabilityCold-acclimated animalsDegrees COpposite effectC. ConverselyDegrees C. ConverselyPhysiological propertiesAnimals
1977
Effects of light on identified Helix pomatia neurons
Pašić M, Ristanović D, Zečević D, Kartelija G. Effects of light on identified Helix pomatia neurons. Comparative Biochemistry And Physiology Part A Molecular & Integrative Physiology 1977, 58: 81-85. DOI: 10.1016/0300-9629(77)90019-6.Peer-Reviewed Original ResearchIdentified Helix pomatia neuronsRight parietal ganglionAction potential frequencyHelix pomatia neuronsParietal ganglionIdentified neuronsSubesophageal ganglionAction potentialsPotential frequencyEffect of photostimulationNeuronsGangliaDepolarizationHyperpolarizationCourse of adaptationPhotosensitive cellsCellsOnset of light