2023
Breast Cancer Mode of Detection in a Population-Based Cohort
Basappa S, Finney Rutten L, Hruska C, Olson J, Jacobson D, Rhodes D. Breast Cancer Mode of Detection in a Population-Based Cohort. Mayo Clinic Proceedings 2023, 98: 278-289. PMID: 36737116, PMCID: PMC9907001, DOI: 10.1016/j.mayocp.2022.10.010.Peer-Reviewed Original ResearchConceptsPopulation-based cohortBreast cancerAdvanced cancerBreast densityRetrospective medical record reviewDense breastsPositive lymph nodesFirst-time diagnosisRochester Epidemiology ProjectMedical record reviewStage of diseaseLarger tumor sizeWomen age 40High-grade tumorsMultiple logistic regressionYears of ageLymph nodesRecord reviewTumor characteristicsTumor sizeCancer characteristicsCancer modeAge 40Clinical attentionCancer
2021
Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study.
Hruska CB, Geske JR, Conners AL, Whaley DH, Rhodes DJ, O'Connor MK, Carter RE, Scott CG, Vachon CM. Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study. American Journal Of Roentgenology 2021, 216: 1193-1204. PMID: 32755210, PMCID: PMC8640999, DOI: 10.2214/ajr.20.23854.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeMolecular breast imagingPostmenopausal womenBreast cancer riskAbsolute riskBreast cancerCohort studyDiscriminatory accuracyDense breastsRisk factorsParenchymal uptakeCancer riskRisk scoreFuture breast cancer diagnosisGreater breast cancer riskBreast cancer risk factorsCox proportional hazards modelGail risk scoreBreast cancer eventsIndependent risk factorSubset of womenCancer risk factorsCase-control studyProportional hazards modelBreast cancer diagnosis
2019
Behavioral and psychological impact of returning breast density results to Latinas: study protocol for a randomized clinical trial
Patel BK, Ridgeway JL, Ghosh K, Rhodes DJ, Borah B, Jenkins S, Suman VJ, Norman A, Jewett M, Singh D, Vachon CM, Radecki Breitkopf C. Behavioral and psychological impact of returning breast density results to Latinas: study protocol for a randomized clinical trial. Trials 2019, 20: 744. PMID: 31852492, PMCID: PMC6921571, DOI: 10.1186/s13063-019-3939-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnxietyBreast DensityBreast NeoplasmsEarly Detection of CancerFemaleHealth CommunicationHealth Knowledge, Attitudes, PracticeHealth LiteracyHispanic or LatinoHumansMammographyMass ScreeningMiddle AgedPatient CompliancePatient Education as TopicQualitative ResearchRandomized Controlled Trials as TopicConceptsRandomized clinical trialsMammographic breast densityLimited resource settingsClinical trialsHealth literacyBreast densityWHO Trial Registration Data SetLatina womenTrial Registration Data SetLimited health literacyLow health literacyBreast cancer riskCancer risk communicationPsychological outcomesMeasurement time pointsDiagnostic delayCancer mortalityBackgroundBreast cancerCommon cancerMammogram resultsStudy protocolCommunity clinicsBreast cancerMammography screeningCancer riskImpact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study
Hruska CB, Hunt KN, Conners AL, Geske JR, Brandt KR, Degnim AC, Vachon CM, O’Connor M, Rhodes DJ. Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study. Breast Cancer Research 2019, 21: 38. PMID: 30850011, PMCID: PMC6408779, DOI: 10.1186/s13058-019-1120-5.Peer-Reviewed Original ResearchConceptsLow-dose tamoxifenMolecular breast imagingBackground parenchymal uptakeOral tamoxifenParenchymal uptakeBreast cancer risk reductionBreast cancer risk factorsEffectiveness of tamoxifenCancer risk factorsCancer risk reductionBreast cancer historyShort-term interventionMean ageCancer historyRisk factorsBreast fibroglandular tissueTamoxifenMolecular breastAverage countStudy participantsSubcutaneous fatPilot studyWomenT-testIntervention
2018
Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study
Hruska CB, Geske JR, Swanson TN, Mammel AN, Lake DS, Manduca A, Conners AL, Whaley DH, Scott CG, Carter RE, Rhodes DJ, O’Connor M, Vachon CM. Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study. Breast Cancer Research 2018, 20: 46. PMID: 29871661, PMCID: PMC5989426, DOI: 10.1186/s13058-018-0973-3.Peer-Reviewed Original Research
2017
Long-term outcomes and predictors of failure after surgery for stage IV apical pelvic organ prolapse
Linder BJ, El-Nashar SA, Mukwege AA, Weaver AL, McGree ME, Rhodes DJ, Gebhart JB, Klingele CJ, Occhino JA, Trabuco EC. Long-term outcomes and predictors of failure after surgery for stage IV apical pelvic organ prolapse. International Urogynecology Journal 2017, 29: 803-810. PMID: 28921036, DOI: 10.1007/s00192-017-3482-5.Peer-Reviewed Original ResearchConceptsUterosacral ligament suspensionApical pelvic organ prolapsePelvic organ prolapseProlapse recurrencePrior hysterectomyProlapse symptomsOrgan prolapseCox proportional hazards modelRecurrent prolapse symptomsMethodsThe medical recordsKaplan-Meier methodType of surgeryLong-term outcomesPredictors of failureApical prolapse repairProportional hazards modelConclusionsYounger agePrimary outcomeSurgical retreatmentApical prolapseProlapse repairExcellent survivalMedical recordsSurgical techniqueSurvival timePatient Acceptance of Half-dose Vs. Half-time Molecular Breast Imaging
Swanson TN, Tran TD, Hruska CB, Solberg CM, Rhodes DJ, Hunt KN, Conners AL, O'Connor MK. Patient Acceptance of Half-dose Vs. Half-time Molecular Breast Imaging. Journal Of Medical Imaging And Radiation Sciences 2017, 49: 39-43. PMID: 30479286, DOI: 10.1016/j.jmir.2017.08.003.Peer-Reviewed Original ResearchConceptsMolecular breast imagingExact testFisher's exact testDuration of examinationBreast imagingPatients' opinionsPatient acceptanceDose reductionExamination comfortMost womenPatient comfortFemale volunteersRadiation doseExamination typesDoseExamination preferencesImagingPatientsGroupNumber of strategiesSurvey responsesVolunteersWomen
2016
Background parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study
Hruska CB, Scott CG, Conners AL, Whaley DH, Rhodes DJ, Carter RE, O’Connor M, Hunt KN, Brandt KR, Vachon CM. Background parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study. Breast Cancer Research 2016, 18: 42. PMID: 27113363, PMCID: PMC4845425, DOI: 10.1186/s13058-016-0704-6.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeCase-control studyBreast cancer casesRisk factorsBreast cancerCancer casesParenchymal uptakeIncident breast cancer casesBreast cancer risk factorsRetrospective case-control studyDense breastsConditional logistic regression analysisInvasive breast cancer casesPostmenopausal hormone useCancer risk factorsFunctional imaging biomarkersBreast cancer riskLogistic regression analysisBI-RADS densityPostmenopausal womenEligible womenMenopausal statusHormone useMedian ageSupplemental screening
2015
Effect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging
Hruska CB, Conners AL, Vachon CM, O'Connor MK, Shuster LT, Bartley AC, Rhodes DJ. Effect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging. Academic Radiology 2015, 22: 1147-1156. PMID: 26112057, PMCID: PMC4532620, DOI: 10.1016/j.acra.2015.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreastBreast DensityChromatography, LiquidCohort StudiesEstradiolEstroneFemaleFollicle Stimulating HormoneFollicular PhaseHumansLuteal PhaseMammographyMiddle AgedMolecular ImagingPremenopauseProgesteroneProspective StudiesRadiopharmaceuticalsSex Hormone-Binding GlobulinTandem Mass SpectrometryTechnetium Tc 99m SestamibiTestosteroneConceptsBackground parenchymal uptakeMolecular breast imagingMenstrual cycle phaseLuteal phaseMenstrual cycleNondense breastsFollicular phaseHormone levelsParenchymal uptakeDense breastsExogenous hormone useRegular menstrual cyclesLevels of TCCycle phaseNormal fibroglandular tissuePremenopausal volunteersPremenopausal womenHormone useSpearman correlation coefficientBreast imagingStudy radiologistsMammographic densityBreastFibroglandular tissueWomenDiagnostic workup and costs of a single supplemental molecular breast imaging screen of mammographically dense breasts.
Hruska CB, Conners AL, Jones KN, O'Connor MK, Moriarty JP, Boughey JC, Rhodes DJ. Diagnostic workup and costs of a single supplemental molecular breast imaging screen of mammographically dense breasts. American Journal Of Roentgenology 2015, 204: 1345-53. PMID: 26001247, PMCID: PMC5036572, DOI: 10.2214/ajr.14.13306.Peer-Reviewed Original ResearchConceptsBenign biopsy rateDiagnostic workupBiopsy rateDense breastsAdditional diagnostic workupCancer detection rateMammography of womenBreast imaging examinationsPositive predictive valueDual-head gamma cameraImaging examinationsPredictive valueMolecular breastBiopsyPatientsWorkupBreastScreening mammographyCancerWomenMammographyMalignancyReference standardGamma cameraDetection rateJournal club: molecular breast imaging at reduced radiation dose for supplemental screening in mammographically dense breasts.
Rhodes DJ, Hruska CB, Conners AL, Tortorelli CL, Maxwell RW, Jones KN, Toledano AY, O'Connor MK. Journal club: molecular breast imaging at reduced radiation dose for supplemental screening in mammographically dense breasts. American Journal Of Roentgenology 2015, 204: 241-51. PMID: 25615744, PMCID: PMC4423604, DOI: 10.2214/ajr.14.13357.Peer-Reviewed Original ResearchConceptsCancer detection rateMolecular breast imagingDense breastsOverall cancer detection rateInvasive cancer detection rateDetection ratePositive predictive valueRadiation dose reductionAsymptomatic womenBilateral cancerDCIS detectionSupplemental screeningInvasive diseaseBiopsy rateDose reductionReduced radiation dosePredictive valueMolecular breastBreastScreening mammographyDiagnostic performanceRadiopharmaceutical activityCancerRadiation doseMammographyFactors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging
O’Connor M, Hruska CB, Tran TD, Swanson T, Conners AL, Jones K, Rhodes DJ. Factors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging. Journal Of Nuclear Medicine Technology 2015, 43: 13-20. PMID: 25613340, DOI: 10.2967/jnmt.114.150128.Peer-Reviewed Original ResearchConceptsMolecular breast imagingBreast tissuePrandial statusOptimal patient preparationPeripheral blood flowBody surface areaCounts/Type of interventionBreast imagingPatient heightPeripheral warmingStudy groupBlood flowSestamibiBreast activityPatient preparationFed stateCount densityMetabolic statusReference groupOblique viewMediolateral oblique viewTissueInterventionBreast thickness
2013
Bioidentical compounded hormones: A pharmacokinetic evaluation in a randomized clinical trial
Sood R, Warndahl RA, Schroeder DR, Singh RJ, Rhodes DJ, Wahner-Roedler D, Bahn RS, Shuster LT. Bioidentical compounded hormones: A pharmacokinetic evaluation in a randomized clinical trial. Maturitas 2013, 74: 375-382. PMID: 23384975, DOI: 10.1016/j.maturitas.2013.01.010.Peer-Reviewed Original ResearchConceptsClinical trialsEstradiol patchLarge clinical trialsRandomized clinical trialsSerum progesterone levelsStudy medicationOral progesteronePostmenopausal womenHormone therapyEstriol levelsSerum levelsStudy armsEstrogen creamPharmacokinetic trialProgesterone levelsComparable dosesHormonal preparationsPharmacokinetic evaluationPharmacokinetic informationDosesTrialsFurther studiesEstrogenProgesteroneBioidentical
2012
Gamma camera breast imaging lexicon.
Conners AL, Maxwell RW, Tortorelli CL, Hruska CB, Rhodes DJ, Boughey JC, Berg WA. Gamma camera breast imaging lexicon. American Journal Of Roentgenology 2012, 199: w767-74. PMID: 23169751, DOI: 10.2214/ajr.11.8298.Peer-Reviewed Original ResearchThe Use of Molecular Breast Imaging to Assess Response in Women Undergoing Neoadjuvant Therapy for Breast Cancer
Wahner-Roedler DL, Boughey JC, Hruska CB, Chen B, Rhodes DJ, Tortorelli CL, Maxwell RW, S. S, O'Connor MK. The Use of Molecular Breast Imaging to Assess Response in Women Undergoing Neoadjuvant Therapy for Breast Cancer. Clinical Nuclear Medicine 2012, 37: 344-350. PMID: 22391702, PMCID: PMC3296091, DOI: 10.1097/rlu.0b013e31824437b3.Peer-Reviewed Original ResearchConceptsMolecular breast imagingNeoadjuvant therapyTumor sizeBreast cancerResidual tumor sizeProspective pilot studyInvasive breast cancerBreast cancer treatmentTumor-specific radiopharmaceuticalsPathologic extentResidual diseasePretreatment valuesTumor responseTumor extentPosttreatment valuesIntravenous injectionPathologic measurementsRadiotracer uptakePredictive valueMolecular breastPatientsCancerCancer treatmentPilot studyInterest analysisEvaluation of Molecular Breast Imaging in Women Undergoing Myocardial Perfusion Imaging with Tc-99m Sestamibi
Hruska CB, Rhodes DJ, Collins DA, Tortorelli CL, Askew JW, O'Connor MK. Evaluation of Molecular Breast Imaging in Women Undergoing Myocardial Perfusion Imaging with Tc-99m Sestamibi. Journal Of Women's Health 2012, 21: 730-738. PMID: 22404787, DOI: 10.1089/jwh.2011.3267.Peer-Reviewed Original ResearchConceptsMolecular breast imagingBreast diseaseBreast cancerDiagnostic yieldMyocardial perfusionHigh-risk benign breast lesionsMyocardial perfusion stress testingRecent negative mammogramStress myocardial perfusionHigh diagnostic yieldStress myocardial perfusion studyBenign breast lesionsNumber of cancersMyocardial perfusion studiesBreast imagingNew cancersRecent mammogramSestamibi injectionNegative mammogramUnnecessary workupPerfusion studiesBreast lesionsCancerIsotope injectionWomenRisk of cardiovascular events in patients with polycystic ovary syndrome.
Iftikhar S, Collazo-Clavell M, Roger V, St Sauver J, Brown R, Cha S, Rhodes D. Risk of cardiovascular events in patients with polycystic ovary syndrome. The Netherlands Journal Of Medicine 2012, 70: 74-80. PMID: 22418753, PMCID: PMC3582228.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeCV eventsLipoprotein cholesterolOvary syndromeRisk factorsCoronary artery bypass graft surgeryRochester Epidemiology Project resourcesArtery bypass graft surgeryHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolType 2 diabetes mellitusHigher body mass indexBypass graft surgeryCardiovascular risk factorsCV risk factorsRetrospective cohort studyAdverse CV outcomesBody mass indexCV outcomesCardiovascular eventsCV diseaseGraft surgeryOlmsted CountyCohort studyPCOS diagnosis
2011
Adherence to Preventive Recommendations: Experience of a Cohort Presenting for Executive Health Care
Shippee ND, Mullan RJ, Nabhan M, Kermott CA, Hagen PT, Rhodes DJ, Montori VM, Murad MH. Adherence to Preventive Recommendations: Experience of a Cohort Presenting for Executive Health Care. Population Health Management 2011, 15: 65-70. PMID: 22092188, DOI: 10.1089/pop.2011.0029.Peer-Reviewed Original ResearchConceptsCancer screeningPreventive servicesOptimal adherence ratesColorectal cancer screeningCervical cancer screeningHealth careMultivariate logistic regressionPredictors of adherencePneumococcal vaccinationTetanus immunizationAdherence ratesPreventive recommendationsHealth behaviorsQuality improvement processDisease preventionLogistic regressionSocioeconomic statusAdherenceImmunizationUse concernsCareUsual barriersScreeningPatientsPresenting
2010
Comparison of radiation exposure and associated radiation‐induced cancer risks from mammography and molecular imaging of the breasta)
O'Connor MK, Li H, Rhodes DJ, Hruska CB, Clancy CB, Vetter RJ. Comparison of radiation exposure and associated radiation‐induced cancer risks from mammography and molecular imaging of the breasta). Medical Physics 2010, 37: 6187-6198. PMID: 21302775, PMCID: PMC2997811, DOI: 10.1118/1.3512759.Peer-Reviewed Original ResearchConceptsBenefit/risk ratioMolecular breast imagingCumulative cancer incidenceCancer incidenceRisk ratioAge groupsExcess absolute risk (EAR) modelsAnnual digital mammographyAttributable risk modelRadiation-induced cancer riskBreast cancer incidenceBreast-specific gammaPositron emission mammographyBEIR VII reportRadiation-induced cancerDense breast tissueAbsolute risk modelsMBq FScreening groupAnnual screeningConventional dosesMBq TcLifetime riskBreast cancerAge 40Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts
Rhodes DJ, Hruska CB, Phillips SW, Whaley DH, O'Connor MK. Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts. Radiology 2010, 258: 106-18. PMID: 21045179, DOI: 10.1148/radiol.10100625.Peer-Reviewed Original ResearchConceptsPositive predictive valueBreast cancerDense breastsDiagnostic yieldNode-negative breast cancerAdditional risk factorsNumber of patientsGamma imagingNumber of biopsiesBreast cancer screeningHIPAA-compliant protocolIpsilateral cancerAbnormal findingsAsymptomatic womenEligible participantsCancer screeningRisk factorsSestamibi injection