2023
Breast Cancer Mode of Detection in a Population-Based Cohort
Basappa S, Finney Rutten L, Hruska C, Olson J, Jacobson D, Rhodes D. Breast Cancer Mode of Detection in a Population-Based Cohort. Mayo Clinic Proceedings 2023, 98: 278-289. PMID: 36737116, PMCID: PMC9907001, DOI: 10.1016/j.mayocp.2022.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBreast NeoplasmsEarly Detection of CancerFemaleHumansMammographyMass ScreeningMiddle AgedRetrospective StudiesConceptsPopulation-based cohortBreast cancerAdvanced cancerBreast densityRetrospective medical record reviewDense breastsPositive lymph nodesFirst-time diagnosisRochester Epidemiology ProjectMedical record reviewStage of diseaseLarger tumor sizeWomen age 40High-grade tumorsMultiple logistic regressionYears of ageLymph nodesRecord reviewTumor characteristicsTumor sizeCancer characteristicsCancer modeAge 40Clinical attentionCancer
2021
Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study.
Hruska CB, Geske JR, Conners AL, Whaley DH, Rhodes DJ, O'Connor MK, Carter RE, Scott CG, Vachon CM. Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study. American Journal Of Roentgenology 2021, 216: 1193-1204. PMID: 32755210, PMCID: PMC8640999, DOI: 10.2214/ajr.20.23854.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeMolecular breast imagingPostmenopausal womenBreast cancer riskAbsolute riskBreast cancerCohort studyDiscriminatory accuracyDense breastsRisk factorsParenchymal uptakeCancer riskRisk scoreFuture breast cancer diagnosisGreater breast cancer riskBreast cancer risk factorsCox proportional hazards modelGail risk scoreBreast cancer eventsIndependent risk factorSubset of womenCancer risk factorsCase-control studyProportional hazards modelBreast cancer diagnosis
2020
Supplemental screening in the dense breast: does molecular breast imaging have a role?
Rhodes DJ. Supplemental screening in the dense breast: does molecular breast imaging have a role? Menopause The Journal Of The North American Menopause Society 2020, 27: 110-112. PMID: 31880677, DOI: 10.1097/gme.0000000000001471.Peer-Reviewed Original Research
2019
Behavioral and psychological impact of returning breast density results to Latinas: study protocol for a randomized clinical trial
Patel BK, Ridgeway JL, Ghosh K, Rhodes DJ, Borah B, Jenkins S, Suman VJ, Norman A, Jewett M, Singh D, Vachon CM, Radecki Breitkopf C. Behavioral and psychological impact of returning breast density results to Latinas: study protocol for a randomized clinical trial. Trials 2019, 20: 744. PMID: 31852492, PMCID: PMC6921571, DOI: 10.1186/s13063-019-3939-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnxietyBreast DensityBreast NeoplasmsEarly Detection of CancerFemaleHealth CommunicationHealth Knowledge, Attitudes, PracticeHealth LiteracyHispanic or LatinoHumansMammographyMass ScreeningMiddle AgedPatient CompliancePatient Education as TopicQualitative ResearchRandomized Controlled Trials as TopicConceptsRandomized clinical trialsMammographic breast densityLimited resource settingsClinical trialsHealth literacyBreast densityWHO Trial Registration Data SetLatina womenTrial Registration Data SetLimited health literacyLow health literacyBreast cancer riskCancer risk communicationPsychological outcomesMeasurement time pointsDiagnostic delayCancer mortalityBackgroundBreast cancerCommon cancerMammogram resultsStudy protocolCommunity clinicsBreast cancerMammography screeningCancer riskBreast Density Awareness, Knowledge, and Attitudes Among US Women: National Survey Results Across 5 Years
Rhodes DJ, Jenkins SM, Hruska CB, Vachon CM, Breitkopf CR. Breast Density Awareness, Knowledge, and Attitudes Among US Women: National Survey Results Across 5 Years. Journal Of The American College Of Radiology 2019, 17: 391-404. PMID: 31756308, DOI: 10.1016/j.jacr.2019.11.003.Peer-Reviewed Original ResearchDose Reduction in Molecular Breast Imaging With a New Image-Processing Algorithm.
Tao AT, Hruska CB, Conners AL, Hunt KN, Swanson TN, Tran TD, Manduca A, Borges L, Maidment ADA, Lake D, Johnson MP, Carter RE, Rhodes DJ, O'Connor MK. Dose Reduction in Molecular Breast Imaging With a New Image-Processing Algorithm. American Journal Of Roentgenology 2019, 214: 185-193. PMID: 31593516, DOI: 10.2214/ajr.19.21582.Peer-Reviewed Original ResearchImpact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study
Hruska CB, Hunt KN, Conners AL, Geske JR, Brandt KR, Degnim AC, Vachon CM, O’Connor M, Rhodes DJ. Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study. Breast Cancer Research 2019, 21: 38. PMID: 30850011, PMCID: PMC6408779, DOI: 10.1186/s13058-019-1120-5.Peer-Reviewed Original ResearchConceptsLow-dose tamoxifenMolecular breast imagingBackground parenchymal uptakeOral tamoxifenParenchymal uptakeBreast cancer risk reductionBreast cancer risk factorsEffectiveness of tamoxifenCancer risk factorsCancer risk reductionBreast cancer historyShort-term interventionMean ageCancer historyRisk factorsBreast fibroglandular tissueTamoxifenMolecular breastAverage countStudy participantsSubcutaneous fatPilot studyWomenT-testInterventionClassification of Background Parenchymal Uptake on Molecular Breast Imaging Using a Convolutional Neural Network
Carter RE, Attia ZI, Geske JR, Conners AL, Whaley DH, Hunt KN, O’Connor M, Rhodes DJ, Hruska CB. Classification of Background Parenchymal Uptake on Molecular Breast Imaging Using a Convolutional Neural Network. JCO Clinical Cancer Informatics 2019, 3: 1-11. PMID: 30807208, PMCID: PMC6446086, DOI: 10.1200/cci.18.00133.Peer-Reviewed Original ResearchConceptsConvolutional neural networkNeural networkDeep learning modelsImage convolutionLearning modelModel performanceBackground parenchymal uptakeTesting dataComputer algorithmAlgorithmExpert radiologistsNetworkDirect matchingDirect matchAccuracyImagesClassificationResearch purposesPerformanceBreast imagingConvolutionEncodingMatchingModelingTraining
2018
Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study
Hruska CB, Geske JR, Swanson TN, Mammel AN, Lake DS, Manduca A, Conners AL, Whaley DH, Scott CG, Carter RE, Rhodes DJ, O’Connor M, Vachon CM. Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study. Breast Cancer Research 2018, 20: 46. PMID: 29871661, PMCID: PMC5989426, DOI: 10.1186/s13058-018-0973-3.Peer-Reviewed Original Research
2017
Patient Acceptance of Half-dose Vs. Half-time Molecular Breast Imaging
Swanson TN, Tran TD, Hruska CB, Solberg CM, Rhodes DJ, Hunt KN, Conners AL, O'Connor MK. Patient Acceptance of Half-dose Vs. Half-time Molecular Breast Imaging. Journal Of Medical Imaging And Radiation Sciences 2017, 49: 39-43. PMID: 30479286, DOI: 10.1016/j.jmir.2017.08.003.Peer-Reviewed Original ResearchConceptsMolecular breast imagingExact testFisher's exact testDuration of examinationBreast imagingPatients' opinionsPatient acceptanceDose reductionExamination comfortMost womenPatient comfortFemale volunteersRadiation doseExamination typesDoseExamination preferencesImagingPatientsGroupNumber of strategiesSurvey responsesVolunteersWomen
2016
Benefit-to–Radiation Risk for Breast Screening Tests Is a Flawed Concept
Rhodes DJ, Hruska CB, Conners AL, Hunt KN, O'Connor MK. Benefit-to–Radiation Risk for Breast Screening Tests Is a Flawed Concept. Radiology 2016, 281: 978-980. PMID: 27870632, DOI: 10.1148/radiol.2016161334.Peer-Reviewed Original ResearchMolecular Breast Imaging and the 2016 Update to the ACR Appropriateness Criteria for Breast Cancer Screening
Covington MF, Rhodes DJ, Pizzitola VJ. Molecular Breast Imaging and the 2016 Update to the ACR Appropriateness Criteria for Breast Cancer Screening. Journal Of The American College Of Radiology 2016, 13: 1408. PMID: 27916107, DOI: 10.1016/j.jacr.2016.09.017.Peer-Reviewed Original ResearchDense Breasts: What Do Our Patients Need to Be Told and Why?
Throckmorton AD, Rhodes DJ, Hughes KS, Degnim AC, Dickson-Witmer D. Dense Breasts: What Do Our Patients Need to Be Told and Why? Annals Of Surgical Oncology 2016, 23: 3119-3127. PMID: 27401446, DOI: 10.1245/s10434-016-5400-3.Peer-Reviewed Original ResearchConceptsBreast cancer prevention strategiesEvidence-based consensus guidelinesDense breastsBreast cancer risk assessmentOnly risk factorCancer prevention strategiesCancer risk assessmentDelaying diagnosisCertain patientsConsensus guidelinesRisk factorsDensity notificationSupplemental imagingPrevention strategiesPatientsBreast densityBreastRisk assessmentCancerDiagnosisWomenBackground parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study
Hruska CB, Scott CG, Conners AL, Whaley DH, Rhodes DJ, Carter RE, O’Connor M, Hunt KN, Brandt KR, Vachon CM. Background parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study. Breast Cancer Research 2016, 18: 42. PMID: 27113363, PMCID: PMC4845425, DOI: 10.1186/s13058-016-0704-6.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeCase-control studyBreast cancer casesRisk factorsBreast cancerCancer casesParenchymal uptakeIncident breast cancer casesBreast cancer risk factorsRetrospective case-control studyDense breastsConditional logistic regression analysisInvasive breast cancer casesPostmenopausal hormone useCancer risk factorsFunctional imaging biomarkersBreast cancer riskLogistic regression analysisBI-RADS densityPostmenopausal womenEligible womenMenopausal statusHormone useMedian ageSupplemental screening
2015
Direct-Conversion Molecular Breast Imaging of Invasive Breast Cancer: Imaging Features, Extent of Invasive Disease, and Comparison Between Invasive Ductal and Lobular Histology.
Conners AL, Jones KN, Hruska CB, Geske JR, Boughey JC, Rhodes DJ. Direct-Conversion Molecular Breast Imaging of Invasive Breast Cancer: Imaging Features, Extent of Invasive Disease, and Comparison Between Invasive Ductal and Lobular Histology. American Journal Of Roentgenology 2015, 205: w374-81. PMID: 26295674, PMCID: PMC8900216, DOI: 10.2214/ajr.14.13502.Peer-Reviewed Original ResearchConceptsInvasive breast cancerMolecular breast imagingInvasive tumor fociBreast imaging examinationsTumor fociMolecular breastBreast cancerImaging featuresInvasive diseasePathology reportsImaging examinationsHistologic profileBreast imagingBreast imaging findingsChi-square testLobular histologyHistologic subtypeInvasive DuctalImaging findingsInvasive cancerBenign reasonsInvasive fociTumor appearanceBlinded reviewLesion typeDiagnostic workup and costs of a single supplemental molecular breast imaging screen of mammographically dense breasts.
Hruska CB, Conners AL, Jones KN, O'Connor MK, Moriarty JP, Boughey JC, Rhodes DJ. Diagnostic workup and costs of a single supplemental molecular breast imaging screen of mammographically dense breasts. American Journal Of Roentgenology 2015, 204: 1345-53. PMID: 26001247, PMCID: PMC5036572, DOI: 10.2214/ajr.14.13306.Peer-Reviewed Original ResearchConceptsBenign biopsy rateDiagnostic workupBiopsy rateDense breastsAdditional diagnostic workupCancer detection rateMammography of womenBreast imaging examinationsPositive predictive valueDual-head gamma cameraImaging examinationsPredictive valueMolecular breastBiopsyPatientsWorkupBreastScreening mammographyCancerWomenMammographyMalignancyReference standardGamma cameraDetection rateAwareness of Breast Density and Its Impact on Breast Cancer Detection and Risk
Rhodes DJ, Radecki Breitkopf C, Ziegenfuss JY, Jenkins SM, Vachon CM. Awareness of Breast Density and Its Impact on Breast Cancer Detection and Risk. Journal Of Clinical Oncology 2015, 33: 1143-1150. PMID: 25732156, PMCID: PMC4551864, DOI: 10.1200/jco.2014.57.0325.Peer-Reviewed Original ResearchMeSH KeywordsAwarenessBlack or African AmericanBreastBreast NeoplasmsCross-Sectional StudiesEarly Detection of CancerEducational StatusFemaleHealth Knowledge, Attitudes, PracticeHealthcare DisparitiesHispanic or LatinoHumansLogistic ModelsMammographyMass ScreeningMiddle AgedMultivariate AnalysisRisk FactorsSocial ClassUnited StatesWhite PeopleConceptsRace/ethnicityBD awarenessWhite non-Hispanic race/ethnicityCancer detectionPostmenopausal hormone therapyNational cross-sectional surveyNon-Hispanic race/ethnicityPrior breast biopsyBreast cancer detectionHealth care providersCross-sectional surveyBreast density informationMultivariable adjustmentHormone therapyDiagnostic evaluationCancer riskCare providersBreast biopsyConnecticut residentsBreast densityHigher household incomeProbability-based sampleHousehold incomeWomenRiskBackground parenchymal uptake during molecular breast imaging and associated clinical factors.
Hruska CB, Rhodes DJ, Conners AL, Jones KN, Carter RE, Lingineni RK, Vachon CM. Background parenchymal uptake during molecular breast imaging and associated clinical factors. American Journal Of Roentgenology 2015, 204: w363-70. PMID: 25714323, PMCID: PMC4423612, DOI: 10.2214/ajr.14.12979.Peer-Reviewed Original ResearchMeSH KeywordsBreast DensityBreast NeoplasmsFemaleHumansMammary Glands, HumanMiddle AgedMolecular ImagingRadionuclide ImagingRetrospective StudiesConceptsBackground parenchymal uptakePostmenopausal hormone therapyParenchymal uptakeBreast cancerMolecular breast imagingHormone therapyClinical factorsMammographic densityDense breastsBI-RADS density categoriesChi-square testMenopausal statusPatient characteristicsHormonal contraceptivesEligible participantsGail modelMenstrual cycleSubsequent riskPrevious mammogramsMolecular breastBreast implantsUnderlying causeCancerBreastWomenJournal club: molecular breast imaging at reduced radiation dose for supplemental screening in mammographically dense breasts.
Rhodes DJ, Hruska CB, Conners AL, Tortorelli CL, Maxwell RW, Jones KN, Toledano AY, O'Connor MK. Journal club: molecular breast imaging at reduced radiation dose for supplemental screening in mammographically dense breasts. American Journal Of Roentgenology 2015, 204: 241-51. PMID: 25615744, PMCID: PMC4423604, DOI: 10.2214/ajr.14.13357.Peer-Reviewed Original ResearchConceptsCancer detection rateMolecular breast imagingDense breastsOverall cancer detection rateInvasive cancer detection rateDetection ratePositive predictive valueRadiation dose reductionAsymptomatic womenBilateral cancerDCIS detectionSupplemental screeningInvasive diseaseBiopsy rateDose reductionReduced radiation dosePredictive valueMolecular breastBreastScreening mammographyDiagnostic performanceRadiopharmaceutical activityCancerRadiation doseMammography
2012
Proof of concept for low‐dose molecular breast imaging with a dual‐head CZT gamma camera. Part II. Evaluation in patients
Hruska CB, Weinmann AL, Skjerseth C, Wagenaar EM, Conners AL, Tortorelli CL, Maxwell RW, Rhodes DJ, O'Connor MK. Proof of concept for low‐dose molecular breast imaging with a dual‐head CZT gamma camera. Part II. Evaluation in patients. Medical Physics 2012, 39: 3476-3483. PMID: 22755727, PMCID: PMC3376157, DOI: 10.1118/1.4719959.Peer-Reviewed Original ResearchConceptsMolecular breast imagingMBq TcDiagnostic accuracyIntrareader agreementMedian lesion sizeLesion detectionPatient studiesEffective radiation doseTelluride gamma cameraSimilar diagnostic accuracyAdequate lesion detectionAdjunct screening techniqueGamma cameraAdministered dosesCount densityClinical careSeparate cohortLesion sizeMBq injectionMolecular breastLow dosesPatientsDense breastsBreast lesionsDoses