2021
Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study.
Hruska CB, Geske JR, Conners AL, Whaley DH, Rhodes DJ, O'Connor MK, Carter RE, Scott CG, Vachon CM. Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study. American Journal Of Roentgenology 2021, 216: 1193-1204. PMID: 32755210, PMCID: PMC8640999, DOI: 10.2214/ajr.20.23854.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeMolecular breast imagingPostmenopausal womenBreast cancer riskAbsolute riskBreast cancerCohort studyDiscriminatory accuracyDense breastsRisk factorsParenchymal uptakeCancer riskRisk scoreFuture breast cancer diagnosisGreater breast cancer riskBreast cancer risk factorsCox proportional hazards modelGail risk scoreBreast cancer eventsIndependent risk factorSubset of womenCancer risk factorsCase-control studyProportional hazards modelBreast cancer diagnosis
2019
Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study
Hruska CB, Hunt KN, Conners AL, Geske JR, Brandt KR, Degnim AC, Vachon CM, O’Connor M, Rhodes DJ. Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study. Breast Cancer Research 2019, 21: 38. PMID: 30850011, PMCID: PMC6408779, DOI: 10.1186/s13058-019-1120-5.Peer-Reviewed Original ResearchConceptsLow-dose tamoxifenMolecular breast imagingBackground parenchymal uptakeOral tamoxifenParenchymal uptakeBreast cancer risk reductionBreast cancer risk factorsEffectiveness of tamoxifenCancer risk factorsCancer risk reductionBreast cancer historyShort-term interventionMean ageCancer historyRisk factorsBreast fibroglandular tissueTamoxifenMolecular breastAverage countStudy participantsSubcutaneous fatPilot studyWomenT-testIntervention
2016
Dense Breasts: What Do Our Patients Need to Be Told and Why?
Throckmorton AD, Rhodes DJ, Hughes KS, Degnim AC, Dickson-Witmer D. Dense Breasts: What Do Our Patients Need to Be Told and Why? Annals Of Surgical Oncology 2016, 23: 3119-3127. PMID: 27401446, DOI: 10.1245/s10434-016-5400-3.Peer-Reviewed Original ResearchConceptsBreast cancer prevention strategiesEvidence-based consensus guidelinesDense breastsBreast cancer risk assessmentOnly risk factorCancer prevention strategiesCancer risk assessmentDelaying diagnosisCertain patientsConsensus guidelinesRisk factorsDensity notificationSupplemental imagingPrevention strategiesPatientsBreast densityBreastRisk assessmentCancerDiagnosisWomenBackground parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study
Hruska CB, Scott CG, Conners AL, Whaley DH, Rhodes DJ, Carter RE, O’Connor M, Hunt KN, Brandt KR, Vachon CM. Background parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study. Breast Cancer Research 2016, 18: 42. PMID: 27113363, PMCID: PMC4845425, DOI: 10.1186/s13058-016-0704-6.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeCase-control studyBreast cancer casesRisk factorsBreast cancerCancer casesParenchymal uptakeIncident breast cancer casesBreast cancer risk factorsRetrospective case-control studyDense breastsConditional logistic regression analysisInvasive breast cancer casesPostmenopausal hormone useCancer risk factorsFunctional imaging biomarkersBreast cancer riskLogistic regression analysisBI-RADS densityPostmenopausal womenEligible womenMenopausal statusHormone useMedian ageSupplemental screening
2012
Risk of cardiovascular events in patients with polycystic ovary syndrome.
Iftikhar S, Collazo-Clavell M, Roger V, St Sauver J, Brown R, Cha S, Rhodes D. Risk of cardiovascular events in patients with polycystic ovary syndrome. The Netherlands Journal Of Medicine 2012, 70: 74-80. PMID: 22418753, PMCID: PMC3582228.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeCV eventsLipoprotein cholesterolOvary syndromeRisk factorsCoronary artery bypass graft surgeryRochester Epidemiology Project resourcesArtery bypass graft surgeryHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolType 2 diabetes mellitusHigher body mass indexBypass graft surgeryCardiovascular risk factorsCV risk factorsRetrospective cohort studyAdverse CV outcomesBody mass indexCV outcomesCardiovascular eventsCV diseaseGraft surgeryOlmsted CountyCohort studyPCOS diagnosis
2010
Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts
Rhodes DJ, Hruska CB, Phillips SW, Whaley DH, O'Connor MK. Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts. Radiology 2010, 258: 106-18. PMID: 21045179, DOI: 10.1148/radiol.10100625.Peer-Reviewed Original ResearchConceptsPositive predictive valueBreast cancerDense breastsDiagnostic yieldNode-negative breast cancerAdditional risk factorsNumber of patientsGamma imagingNumber of biopsiesBreast cancer screeningHIPAA-compliant protocolIpsilateral cancerAbnormal findingsAsymptomatic womenEligible participantsCancer screeningRisk factorsSestamibi injection
2002
Identifying and Counseling Women at Increased Risk for Breast Cancer
Rhodes DJ. Identifying and Counseling Women at Increased Risk for Breast Cancer. Mayo Clinic Proceedings 2002, 77: 355-361. PMID: 11936931, DOI: 10.4065/77.4.355.Peer-Reviewed Original ResearchConceptsBreast cancerRisk factorsBreast cancer prevention clinical trialsCancer prevention clinical trialsPossible risk factorsPrevention clinical trialsRisk reductionRisk assessment toolLifestyle modificationProphylactic mastectomyClose surveillanceClinical trialsFamily historyCounseling womenNumerical risk estimatesCancerRisk estimatesIndividual riskSuch womenWomenRiskAbsence of consensusComplex family historiesAssessment toolOptions