A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci
Kenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, Marder K, McGovern DP, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I. A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci. PLOS Genetics 2012, 8: e1002559. PMID: 22412388, PMCID: PMC3297573, DOI: 10.1371/journal.pgen.1002559.Peer-Reviewed Original ResearchMeSH KeywordsChromosomes, Human, Pair 5Cohort StudiesCrohn DiseaseGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansJewsLinkage DisequilibriumWhite PeopleConceptsGenome-wide association studiesGenome-wide associationWide significant associationsGenome-wide scanTotal genetic varianceNovel susceptibility lociRaw genotype dataPlausible candidate genesCD susceptibility lociGenetic variationGenetic varianceCandidate genesAdditional lociAssociation studiesGenetic studiesSusceptibility lociCD lociGenotype dataLociNovel signalAJ populationHost immune systemEuropean ancestryAshkenazi Jewish descentComplex disorder