2021
Novel and Emerging Therapies for Inflammatory Bowel Disease
Al-Bawardy B, Shivashankar R, Proctor DD. Novel and Emerging Therapies for Inflammatory Bowel Disease. Frontiers In Pharmacology 2021, 12: 651415. PMID: 33935763, PMCID: PMC8080036, DOI: 10.3389/fphar.2021.651415.BooksInflammatory bowel diseaseBowel diseaseAnti-tumor necrosis factorPotential systemic manifestationsSecondary treatment failureTreatment response ratesJanus kinase inhibitorSelective Janus kinase inhibitorNew therapeutic targetsEmerging TherapiesCurrent biologicsIntestinal inflammationSystemic manifestationsUlcerative colitisCrohn's diseaseTreatment failureSafety profileNecrosis factorTherapeutic targetResponse rateDiseaseKinase inhibitorsTarget agentsInhibitorsTolerability
2020
The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases
Damsky W, Peterson D, Ramseier J, Al-Bawardy B, Chun H, Proctor D, Strand V, Flavell RA, King B. The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases. Journal Of Allergy And Clinical Immunology 2020, 147: 814-826. PMID: 33129886, DOI: 10.1016/j.jaci.2020.10.022.BooksConceptsTranscription pathwayDownstream Janus kinaseJAK-signal transducerSmall molecule inhibitorsSignal transducerJanus kinaseJAK inhibitorsAutoimmune/inflammatory disordersKinase inhibitorsActivatorPathwayInhibitorsCytokine activityInflammatory diseasesImmune systemKinaseOrgan systemsBiologyCytokinesTransducerInhibition