2001
Initial Plasma HIV-1 RNA Levels and Progression to AIDS in Women and Men
Sterling T, Vlahov D, Astemborski J, Hoover D, Margolick J, Quinn T. Initial Plasma HIV-1 RNA Levels and Progression to AIDS in Women and Men. New England Journal Of Medicine 2001, 344: 720-725. PMID: 11236775, DOI: 10.1056/nejm200103083441003.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAnti-HIV AgentsCD4 Lymphocyte CountDisease ProgressionDisease-Free SurvivalEligibility DeterminationFemaleHIV AntibodiesHIV InfectionsHIV-1HumansLongitudinal StudiesMalePractice Guidelines as TopicRegression AnalysisReverse Transcriptase Polymerase Chain ReactionRiskRNA, ViralSex FactorsViral LoadConceptsInitial viral loadMedian initial viral loadHIV-1 RNAViral loadLymphocyte countHuman immunodeficiency virus type 1 (HIV-1) infectionPlasma HIV-1 RNA levelsHIV-1 RNA levelsHIV-1 RNA copiesFemale injection drug usersVirus type 1 infectionHIV-1 seroconversionMedian initial CD4Risk of progressionHIV-1 infectionType 1 infectionInjection drug usersLikelihood of progressionRate of progressionAntiretroviral therapyInitial CD4Hazard ratioAntiretroviral treatmentTreatment guidelinesImmunodeficiency syndrome
2000
Correlates of enrollment in methadone maintenance treatment programs differ by HIV-serostatus
Shah N, Celentano D, Vlahov D, Stambolis V, Johnson L, Nelson K, Strathdee S. Correlates of enrollment in methadone maintenance treatment programs differ by HIV-serostatus. AIDS 2000, 14: 2035-2043. PMID: 10997409, DOI: 10.1097/00002030-200009080-00020.Peer-Reviewed Original ResearchMeSH KeywordsAdultBaltimoreCohort StudiesFemaleHealth Services AccessibilityHIV AntibodiesHIV InfectionsHIV SeronegativityHIV SeropositivityHumansMaleMethadoneMiddle AgedNeedle-Exchange ProgramsProspective StudiesRisk-TakingSocioeconomic FactorsSubstance Abuse Treatment CentersSubstance Abuse, IntravenousConceptsMethadone maintenance treatment programInjection drug usersMaintenance treatment programNeedle exchange programsHIV serostatusHIV-seronegative injection drug usersSeronegative injection drug usersHIV-negative injection drug usersTreatment programHIV-seropositive participantsHealth care providersTreatment slotsNeedle exchange program participantsAfrican AmericansHIV testProspective cohortCare providersDrug usersProgram attendanceOlder ageCertain subgroupsVulnerable populationsSimilar proportionsBehavioral factorsEnrollment
1999
The Effect of Drug-Injection Behavior on Genetic Evolution of HIV-1
Carneiro M, Yu X, Lyles C, Templeton A, Weisstein A, Safaeian M, Farzadegan H, Vlahov D, Markham R. The Effect of Drug-Injection Behavior on Genetic Evolution of HIV-1. The Journal Of Infectious Diseases 1999, 180: 1025-1032. PMID: 10479127, DOI: 10.1086/315044.Peer-Reviewed Original ResearchLongitudinal Human Immunodeficiency Virus Type 1 Load in the Italian Seroconversion Study: Correlates and Temporal Trends of Virus Load
Lyles C, Dorrucci M, Vlahov D, Pezzotti P, Angarano G, Sinicco A, Alberici F, Alcorn T, Vella S, Rezza G. Longitudinal Human Immunodeficiency Virus Type 1 Load in the Italian Seroconversion Study: Correlates and Temporal Trends of Virus Load. The Journal Of Infectious Diseases 1999, 180: 1018-1024. PMID: 10479126, DOI: 10.1086/314980.Peer-Reviewed Original ResearchConceptsHIV-1 loadVirus loadHuman immunodeficiency virus type 1 (HIV-1) loadHuman immunodeficiency virus type 1 (HIV-1) seroconvertersCD4 cells/microL.Low CD4 cell countsItalian Seroconversion StudyCD4 cell countCells/microL.Injection drug useCourse of diseaseReverse transcriptase-polymerase chain reactionHigh virus loadTranscriptase-polymerase chain reactionClinical AIDSMale sexProspective studyDisease progressionSeroconversion StudyCell countDrug useSustained increaseSeroconversionAIDSFrozen serumSex Differences in Longitudinal Human Immunodeficiency Virus Type 1 RNA Levels among Seroconverters
Sterling T, Lyles C, Vlahov D, Astemborski J, Margolick J, Quinn T. Sex Differences in Longitudinal Human Immunodeficiency Virus Type 1 RNA Levels among Seroconverters. The Journal Of Infectious Diseases 1999, 180: 666-672. PMID: 10438353, DOI: 10.1086/314967.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1 RNA levelsHIV-1 seroconvertersSex differencesCopies/mLHIV-1 pathogenesisInjection drug usersCase-control studyTime of seroconversionCross-sectional studyCourse of infectionMale patientsRapid progressorsFemale patientsCopies/Drug usersMale controlsVirus levelsPatientsRNA levelsSeroconvertersWomenMenNonprogressorsSeroconversionProgressors
1998
Operation Red Box: A Pilot Project of Needle and Syringe Drop Boxes for Injection Drug Users in East Baltimore
Riley E, Beilenson P, Vlahov D, Smith L, Koenig M, Jones T, Doherty M. Operation Red Box: A Pilot Project of Needle and Syringe Drop Boxes for Injection Drug Users in East Baltimore. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1998, 18: s120-s125. PMID: 9663634, DOI: 10.1097/00042560-199802001-00020.Peer-Reviewed Original Research
1996
Temporal Trends of Initial CD4 Cell Counts Following Human Immunodeficiency Virus Seroconversion in Italy, 1985–1992
Galai N, Lepri A, Vlahov D, Pezzotti P, Sinicco A, Rezza G, Study H. Temporal Trends of Initial CD4 Cell Counts Following Human Immunodeficiency Virus Seroconversion in Italy, 1985–1992. American Journal Of Epidemiology 1996, 143: 278-282. PMID: 8561162, DOI: 10.1093/oxfordjournals.aje.a008739.Peer-Reviewed Original ResearchConceptsCD4 cell measurementsInitial CD4 cell countHuman immunodeficiency virus (HIV) seroconversionCD4 cell countCell countCD4 cell count increaseItalian Seroconversion StudyLow CD4 countMonths of seroconversionYear of seroconversionCD4 cell levelsCell count increaseMedian lag timeCD4 countCD4 levelsHIV seroconversionPositive serologyNegative serologyHIV seroconvertersClinical centersRisk groupsSeroconversion StudySeroconversionMultivariate modelLag time
1994
Field effectiveness of needle disinfection among injecting drug users.
Vlahov D, Astemborski J, Solomon L, Nelson K. Field effectiveness of needle disinfection among injecting drug users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1994, 7: 760-6. PMID: 8207660.Peer-Reviewed Original ResearchConceptsHIV seroconversionOdds ratioDrug usersNeedle disinfectionPutative protective effectCase-control studyCorresponding odds ratiosSterile injection equipmentDisinfectant useInjection equipmentLimited statistical powerStudy entryHIV seroconvertersResidual confoundingPossible confoundersCocaine injectionProtective effectSeroconversionDrug useUse of disinfectantsBlack heterosexualsPractice variablesField effectivenessSeroconvertersSeronegatives
1991
Prevalence of Antibody to HIV-1 Among Entrants to US Correctional Facilities
Vlahov D, Brewer T, Castro K, Narkunas J, Salive M, Ullrich J, Muñoz A. Prevalence of Antibody to HIV-1 Among Entrants to US Correctional Facilities. JAMA 1991, 265: 1129-1132. PMID: 1995998, DOI: 10.1001/jama.1991.03460090077036.Peer-Reviewed Original ResearchConceptsPrevalence of antibodiesHuman immunodeficiency virus type 1Immunodeficiency virus type 1HIV-1 prevalenceHIV-1 seroprevalenceAge 25 yearsVirus type 1US correctional facilitiesConsecutive malesHIV-1Older womenOlder menPrevention programsType 1Young womenPrevalenceWomenCorrectional systemYoung menMenSeroprevalenceAntibodiesProgram planningCorrectional facilitiesThe ALIVE study, a longitudinal study of HIV-1 infection in intravenous drug users: description of methods and characteristics of participants.
Vlahov D, Anthony J, Munoz A, Margolick J, Nelson K, Celentano D, Solomon L, Polk B. The ALIVE study, a longitudinal study of HIV-1 infection in intravenous drug users: description of methods and characteristics of participants. NIDA Research Monograph 1991, 109: 75-100. PMID: 1661376.Peer-Reviewed Original Research
1990
Seasonal and annual variation of antibody to HIV-1 among male inmates entering Maryland prisons
Vlahov D, Muñoz A, Brewer F, Taylor E, Canner C, Polk B. Seasonal and annual variation of antibody to HIV-1 among male inmates entering Maryland prisons. AIDS 1990, 4: 345-350. PMID: 2350455, DOI: 10.1097/00002030-199004000-00010.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultBlack or African AmericanDistrict of ColumbiaForecastingHealth Planning OrganizationsHispanic or LatinoHIV AntibodiesHIV SeropositivityHIV SeroprevalenceHumansMaleMarylandMultivariate AnalysisPeriodicityPrisonersSeasonsState Health Planning and Development AgenciesSubstance Abuse, IntravenousUnited StatesConceptsIncoming male inmatesHIV-1HIV-1 seroprevalenceHIV-1 infectionEnzyme-linked immunosorbentMultivariate adjustmentPrevious serosurveysSignificant changesBlack raceMale inmatesPrison entrantsMultivariate analysisExcess serumMaryland prisonsWestern blotSeroprevalenceStudy periodAntibodiesDemographic variablesAgeSubgroups
1989
Cocaine injection and ethnicity in parenteral drug users during the early years of the human immunodeficiency virus (hiv) epidemic in new york city
Novick D, Trigg H, Jarlais D, Friedman S, Vlahov D, Kreek M. Cocaine injection and ethnicity in parenteral drug users during the early years of the human immunodeficiency virus (hiv) epidemic in new york city. Journal Of Medical Virology 1989, 29: 181-185. PMID: 2614398, DOI: 10.1002/jmv.1890290307.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusParenteral drug usersHispanic patientsDrug usersHIV infectionHuman immunodeficiency virus (HIV) epidemicImmune deficiency syndromeMultiple logistic regressionUse of cocaineNew York CityWhite patientsBlack patientsLiver diseaseImmunodeficiency virusDeficiency syndromeHIV epidemicCocaine injectionHigh prevalencePatientsDrug useEtiologic agentMedical problemsLogistic regressionExtensive epidemicHeroinTemporal trends of human immunodeficiency virus type 1 (HIV-1) infection among inmates entering a statewide prison system, 1985-1987.
Vlahov D, Brewer F, Muñoz A, Hall D, Taylor E, Polk B. Temporal trends of human immunodeficiency virus type 1 (HIV-1) infection among inmates entering a statewide prison system, 1985-1987. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1989, 2: 283-90. PMID: 2786071.Peer-Reviewed Original ResearchConceptsIntravenous drug usersHuman immunodeficiency virus type 1 (HIV-1) infectionHuman immunodeficiency virus type 1Virus type 1 infectionImmunodeficiency virus type 1Incoming male inmatesHIV-1 seroprevalenceIntravenous drug useType 1 infectionImmune deficiency syndromeCause of deathRisk of infectionVirus type 1Drug use variablesWestern blot techniqueCrude prevalenceRisk factorsUnivariate analysisDeficiency syndromeHIV-1Temporal trendsDrug usersDrug useExcess serumIncoming inmates