2004
Acceptance and completion of hepatitis B vaccination among drug users in New York City.
Ompad D, Galea S, Wu Y, Fuller C, Latka M, Koblin B, Vlahov D. Acceptance and completion of hepatitis B vaccination among drug users in New York City. Communicable Disease And Public Health 2004, 7: 294-300. PMID: 15779793.Peer-Reviewed Original ResearchConceptsDrug usersVaccine acceptanceHepatitis B vaccination ratesNon-injecting drug usersDaily crack usersPrevious HBV infectionHepatitis B vaccinationB vaccination ratesOngoing prospective studyB vaccinationDaily injectorsHBV testingHBV vaccinationVaccination seriesVaccine acceptorsHBV infectionVaccine seriesPrevious vaccinationRisk behavior questionnaireProspective studyVaccination acceptanceVaccination ratesSerological evidenceSeries completionVaccination
2002
Factors Associated with HIV Seroprevalence among Participants Enrolling at a Needle Exchange Program
Vertefeuille J, Strathdee S, Huettner S, Brown M, Vlahov D. Factors Associated with HIV Seroprevalence among Participants Enrolling at a Needle Exchange Program. Journal Of Drug Issues 2002, 32: 1125-1138. DOI: 10.1177/002204260203200408.Peer-Reviewed Original ResearchInjection drug usersHIV seroprevalenceHIV-seronegative counterpartsHIV-seropositive individualsHIV risk factorsDaily cocaine injectionsDaily heroin injectionDrug use characteristicsHarms of drugsHIV seropositive statusNeedle exchange programsLogistic regression modelsSpeedball injectionHIV antibodiesHIV infectionHeroin injectionProspective studyRisk factorsCocaine injectionFactors AssociatedDrug usersMultivariate modelProgram entryHIVSeroprevalenceProspective study of infective endocarditis among injection drug users
Wilson L, Thomas D, Astemborski J, Freedman T, Vlahov D. Prospective study of infective endocarditis among injection drug users. The Journal Of Infectious Diseases 2002, 185: 1761-1766. PMID: 12085322, DOI: 10.1086/340827.Peer-Reviewed Original ResearchConceptsInjection drug usersInfective endocarditisHIV-seronegative injection drug usersDrug usersHuman immunodeficiency virus (HIV) infectionCohort of IDUsInjection drug use behaviorsCD4 lymphocyte countImmunodeficiency virus infectionCase-control studyDrug use frequencyDrug use behaviorsHIV immunosuppressionLymphocyte countCase patientsHIV statusAlcohol intakeProspective studyInverse associationRisk factorsVirus infectionMultivariate analysisEndocarditisHIVIncidence
2001
Sexual and drug risk-related behaviours after initiating highly active antiretroviral therapy among injection drug users
Vlahov D, Safaien M, Lai S, Strathdee S, Johnson L, Sterling T, Celentano D. Sexual and drug risk-related behaviours after initiating highly active antiretroviral therapy among injection drug users. AIDS 2001, 15: 2311-2316. PMID: 11698705, DOI: 10.1097/00002030-200111230-00013.Peer-Reviewed Original ResearchConceptsInjection drug usersHIV-seropositive injection drug usersActive antiretroviral therapyUntreated groupHigh-risk behaviorsAntiretroviral therapyConsecutive visitsDrug usersRisk behaviorsInitiation of HAARTCD4 cell countOngoing prospective studySemi-annual interviewsLinear growth curve analysesHAART useMedian ageMedication useProspective studyNeedle sharingHAARTCell countUnprotected sexRisk-related behaviorsCurve analysisStudy periodIsoniazid Preventive Therapy, Hepatitis C Virus Infection, and Hepatotoxicity among Injection Drug Users Infected with Mycobacterium tuberculosis
Sadaphal P, Astemborski J, Graham N, Sheely L, Bonds M, Madison A, Vlahov D, Thomas D, Sterling T. Isoniazid Preventive Therapy, Hepatitis C Virus Infection, and Hepatotoxicity among Injection Drug Users Infected with Mycobacterium tuberculosis. Clinical Infectious Diseases 2001, 33: 1687-1691. PMID: 11641824, PMCID: PMC2650436, DOI: 10.1086/323896.Peer-Reviewed Original ResearchConceptsHepatitis C virusInjection drug usersTuberculosis infectionValue elevationDrug usersCurrent injection drug useLatent Mycobacterium tuberculosis infectionHepatitis C virus infectionHepatitis B surface antigenLow HCV prevalenceC virus infectionIsoniazid preventive therapyInjection drug useM. tuberculosis infectionMycobacterium tuberculosis infectionHIV-1 infectionHuman immunodeficiency virusB surface antigenConcurrent alcohol useDrug discontinuationHCV prevalencePreventive therapyImmunodeficiency virusProspective studyTransaminase valuesSex Differences in Risk Factors for HIV Seroconversion Among Injection Drug Users: A 10-Year Perspective
Strathdee S, Galai N, Safaiean M, Celentano D, Vlahov D, Johnson L, Nelson K. Sex Differences in Risk Factors for HIV Seroconversion Among Injection Drug Users: A 10-Year Perspective. JAMA Internal Medicine 2001, 161: 1281-1288. PMID: 11371255, DOI: 10.1001/archinte.161.10.1281.Peer-Reviewed Original ResearchConceptsInjection drug usersIncidence of HIVHIV seroconversionRisk factorsProspective studyDrug usersHigh-risk heterosexual activityHuman immunodeficiency virus interventionsHIV-negative injection drug usersHuman immunodeficiency virus (HIV) infectionFemale injection drug usersImmunodeficiency virus infectionInjection drug useDrug-related risksHomosexual activityTime-dependent covariatesHIV testMedian agePerson yearsDaily injectionsNeedle sharingCocaine injectionHIV riskVirus infectionSeroconversionDynamics of behavioral risk factors for HIV/AIDS: a 6-year prospective study of injection drug users
Celentano D, Muñoz A, Cohn S, Vlahov D. Dynamics of behavioral risk factors for HIV/AIDS: a 6-year prospective study of injection drug users. Drug And Alcohol Dependence 2001, 61: 315-322. PMID: 11164696, DOI: 10.1016/s0376-8716(00)00154-x.Peer-Reviewed Original ResearchConceptsBehavioral risk factorsInjection drug usersProspective studyHIV transmissionRisk factorsDrug usersHIV behavioral risk factorsIncremental risk reductionHIV/AIDSRisk reductionHIV-seronegativesTime-dependent covariatesDrug injectorsHigh riskRisk behaviorsBehavioral risksBehavior changeRisky behaviorsRegression modelsLongitudinal predictorsRiskSeronegativesHIVAIDSAbstinence
1999
Longitudinal Human Immunodeficiency Virus Type 1 Load in the Italian Seroconversion Study: Correlates and Temporal Trends of Virus Load
Lyles C, Dorrucci M, Vlahov D, Pezzotti P, Angarano G, Sinicco A, Alberici F, Alcorn T, Vella S, Rezza G. Longitudinal Human Immunodeficiency Virus Type 1 Load in the Italian Seroconversion Study: Correlates and Temporal Trends of Virus Load. The Journal Of Infectious Diseases 1999, 180: 1018-1024. PMID: 10479126, DOI: 10.1086/314980.Peer-Reviewed Original ResearchConceptsHIV-1 loadVirus loadHuman immunodeficiency virus type 1 (HIV-1) loadHuman immunodeficiency virus type 1 (HIV-1) seroconvertersCD4 cells/microL.Low CD4 cell countsItalian Seroconversion StudyCD4 cell countCells/microL.Injection drug useCourse of diseaseReverse transcriptase-polymerase chain reactionHigh virus loadTranscriptase-polymerase chain reactionClinical AIDSMale sexProspective studyDisease progressionSeroconversion StudyCell countDrug useSustained increaseSeroconversionAIDSFrozen serum
1998
Prevalence and Incidence of Hepatitis C Virus Infection Among Young Adult Injection Drug Users
Garfein R, Doherty M, Monterroso E, Thomas D, Nelson K, Vlahov D. Prevalence and Incidence of Hepatitis C Virus Infection Among Young Adult Injection Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1998, 18: s11-s19. PMID: 9663618, DOI: 10.1097/00042560-199802001-00004.Peer-Reviewed Original ResearchConceptsYoung adult injection drug usersAdult injection drug usersInjection drug usersHepatitis C virus infectionC virus infectionHCV infectionVirus infectionDrug usersHCV-seronegative participantsTransmission of HCVCommunity-based outreachSecond-generation antibodiesHCV seroconversionHCV seroprevalenceCommunity outreach educationProspective studyRisk factorsSemiannual interviewsHigh riskInjecting practicesSterile syringesBivariate analysisLogistic regressionInfectionHCV
1996
The relationship between risk networks' patterns of crack cocaine and alcohol consumption and HIV-related sexual behaviors among adult injection drug users: a prospective study
Latkin C, Mandell W, Vlahov D. The relationship between risk networks' patterns of crack cocaine and alcohol consumption and HIV-related sexual behaviors among adult injection drug users: a prospective study. Drug And Alcohol Dependence 1996, 42: 175-181. PMID: 8912800, DOI: 10.1016/s0376-8716(96)01279-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBlack or African AmericanComorbidityCrack CocaineFemaleFollow-Up StudiesHealth Knowledge, Attitudes, PracticeHeroin DependenceHIV InfectionsHumansMaleOpioid-Related DisordersPeer GroupProspective StudiesRisk FactorsSexual BehaviorSocial FacilitationSocial SupportSubstance Abuse, IntravenousConceptsInjection drug usersSexual risk behaviorsRisk behaviorsAlcohol consumptionDrug usersInner-city injection drug usersSex partnersAdult injection drug usersAlcohol useHIV preventive interventionsMultiple sex partnersSexual behaviorCrack cocaine useCasual sex partnersSelf-reported sexual behaviorSelf-reported drugProspective studyIndex participantsNontreatment sampleSocial contextProspective associationsPreventive interventionsCocaine useAfrican American malesInfluence of peersAlcohol Use and T‐Lymphocyte Subsets among Injection Drug Users with HIV‐1 Infection: A Prospective Analysis
Crum R, Galai N, Cohn S, Celentano D, Vlahov D. Alcohol Use and T‐Lymphocyte Subsets among Injection Drug Users with HIV‐1 Infection: A Prospective Analysis. Alcohol Clinical And Experimental Research 1996, 20: 364-371. PMID: 8730231, DOI: 10.1111/j.1530-0277.1996.tb01654.x.Peer-Reviewed Original ResearchConceptsInjection drug usersCohort of IDUsT lymphocyte subsetsDrinks/weekHIV seroconversionAlcohol useYears postseroconversionDrug usersAlcohol categoriesHIV-positive injection drug usersCD8 absolute countsHIV-1 seroconvertersProgression of immunodeficiencyLevels of CD4Intravenous drug useT lymphocyte subpopulationsFirst prospective studyHIV-1 infectionTime of seroconversionSignificant differencesEarly intervention programsHIV infectionHIV progressionOutpatient clinicProspective study
1995
Clinical characteristics and prognostic value of acute retroviral syndrome among injecting drug users
Dorrucci M, Rezza G, Vlahov D, Pezzotti P, Sinicco A, Nicolosi A, Lazzarin A, Galai N, Gafà S, Pristerà R. Clinical characteristics and prognostic value of acute retroviral syndrome among injecting drug users. AIDS 1995, 9: 597-604. PMID: 7662199, DOI: 10.1097/00002030-199506000-00011.Peer-Reviewed Original ResearchConceptsAcute retroviral syndromeHIV infectionHIV seroconvertersRelative hazardDrug usersFirst positive HIV testYear of seroconversionPositive HIV testRate of CD4Kaplan-Meier estimatesCumulative AIDS incidenceAsymptomatic seroconvertersHIV seroconversionClinical characteristicsHIV testClinical progressionPrognostic valueProspective studyClinical centersSeroconvertersCell declineSeroconversionCell countSyndromeNatural history
1994
Impact of HIV infection on non-AIDS mortality among Italian injecting drug users
Zaccarelli M, Gattari P, Rezza G, Conti S, Spizzichino L, Vlahov D, Ippolito G, Lelli V, Valenzi C. Impact of HIV infection on non-AIDS mortality among Italian injecting drug users. AIDS 1994, 8: 345-350. PMID: 8031512, DOI: 10.1097/00002030-199403000-00008.Peer-Reviewed Original ResearchConceptsHIV seropositivesHIV serostatusAIDS mortalityMortality rateAge-adjusted standardized mortality ratiosDrug usersHIV-negative IDUsHIV-seronegative IDUsHIV-seropositive IDUPerson-time techniquesStandardized mortality ratioCause-specific mortalityDrug treatment centersRate of deathHIV-seronegativesPossible HIVHIV infectionHIV testingProspective studyMortality ratioExcess mortalityGeneral populationOverdose mortalityAIDS causesHIV
1993
Elevated serum levels of neopterin but not β2-microglobulin in HIV-1-seronegative injecting drug users
Strickler H, Blanchard J, Vlahov D, Taylor E, Muñoz A, Nelson K, Margolick J. Elevated serum levels of neopterin but not β2-microglobulin in HIV-1-seronegative injecting drug users. AIDS 1993, 7: 361-368. PMID: 8471199, DOI: 10.1097/00002030-199303000-00009.Peer-Reviewed Original ResearchConceptsDrug useNeopterin levelsSerum levelsDrug usersSerum beta 2MBeta 2M levelsSerum beta 2M levelsMean neopterin levelsSerum neopterin levelsElevated serum levelsHIV-1 infectionCellular immune activationBeta 2MRisk factor variablesIntravenous Experience (ALIVE) studyM levelsMale IDUsSerum neopterinImmune activationProspective studyImmunocompetent cellsHIV-1Β2-microglobulinConsecutive daysNeopterin
1991
Antibody to Hepatitis C Virus among Cardiac Surgery Patients, Homosexual Men, and Intravenous Drug Users in Baltimore, Maryland
Donahue J, Nelson K, Mufioz A, Vlahov D, Rennie L, Taylor E, Saah A, Cohn S, Odaka N, Farzadegan H. Antibody to Hepatitis C Virus among Cardiac Surgery Patients, Homosexual Men, and Intravenous Drug Users in Baltimore, Maryland. American Journal Of Epidemiology 1991, 134: 1206-1211. PMID: 1720924, DOI: 10.1093/oxfordjournals.aje.a116023.Peer-Reviewed Original ResearchConceptsHepatitis C virusIntravenous drug useIntravenous drug usersC virusHepatitis CDrug usersDrug useHuman immunodeficiency virus (HIV) infectionHepatitis C seropositiveHepatitis C seropositivityHIV-1 statusCardiac surgery patientsImmunodeficiency virus infectionIncidence of antibodiesMulti-transfused patientsSexual behavior variablesC seropositivitySurgery patientsCardiac surgeryHepatitis AProspective studyRisk factorsBlood exposureVirus infectionHIV-1Hiv Knowledge and Attitudes among Intravenous Drug Users: Comparisons to the U.S. Population and by Drug Use Behaviors
Celentano D, Vlahov D, Menon A, Polk B. Hiv Knowledge and Attitudes among Intravenous Drug Users: Comparisons to the U.S. Population and by Drug Use Behaviors. Journal Of Drug Issues 1991, 21: 635-649. DOI: 10.1177/002204269102100311.Peer-Reviewed Original ResearchHIV-1 infectionIntravenous drug usersHIV-1Drug use behaviorsAIDS knowledgeDrug usersHigh riskHIV-1 antibody statusU.S. populationHIV-1 epidemicHistory of treatmentRoutes of transmissionMethods of preventionGeneral AIDS knowledgeAntibody statusProspective studyHIV knowledgeDrug treatmentLower riskTreatment opportunitiesKnowledge of AIDSRisk behaviorsNatural historyBaseline surveyInfection