1998
Infection with Dual-Tropic Human Immunodeficiency Virus Type 1 Variants Associated with Rapid Total T Cell Decline and Disease Progression in Injection Drug Users
Yu X, Wang Z, Vlahov D, Markham R, Farzadegan H, Margolick J. Infection with Dual-Tropic Human Immunodeficiency Virus Type 1 Variants Associated with Rapid Total T Cell Decline and Disease Progression in Injection Drug Users. The Journal Of Infectious Diseases 1998, 178: 388-396. PMID: 9697718, DOI: 10.1086/515646.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SequenceCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell LineCells, CulturedDisease ProgressionFemaleGenetic VariationHIV Envelope Protein gp120HIV SeropositivityHIV-1HumansMaleMolecular Sequence DataPeptide FragmentsSequence Homology, Amino AcidSubstance Abuse, IntravenousTime FactorsT-LymphocytesConceptsInjection drug usersSI variantsDisease progressionHuman immunodeficiency virus type 1 variantsDrug usersHuman immunodeficiency virus type 1Immunodeficiency virus type 1HIV-1 transmissionT cell levelsSlow disease progressionT-cell declineDual-tropic virusesType 1 variantsSyncytium-inducing (SI) variantsVirus type 1T cell linesDual tropicNSI variantsSlow progressorsRapid progressionNSI phenotypeT cellsCell declineInitial infectionType 1
1996
Selective transmission of human immunodeficiency virus type 1 variants to SCID mice reconstituted with human peripheral blood monoclonal cells
Markham R, Schwartz D, Templeton A, Margolick J, Farzadegan H, Vlahov D, Yu X. Selective transmission of human immunodeficiency virus type 1 variants to SCID mice reconstituted with human peripheral blood monoclonal cells. Journal Of Virology 1996, 70: 6947-6954. PMID: 8794338, PMCID: PMC190744, DOI: 10.1128/jvi.70.10.6947-6954.1996.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1 variantsHu-PBLSCID miceType 1 variantsPrimary isolatesNSI variantsSCID mouse model systemPeripheral blood mononuclear cellsBlood mononuclear cellsHIV-1 variantsMT-2 cellsMouse model systemMononuclear cellsRelative infectiousnessCell culturesVaccine developmentClinical settingMiceEnv sequencesMonoclonal cellsTissue culture systemCellsIsolatesCulture systemPreferential transmission