2007
Early immunologic and virologic responses to highly active antiretroviral therapy and subsequent disease progression among HIV-infected injection drug users
Mehta S, Lucas G, Astemborski J, Kirk G, Vlahov D, Galai N. Early immunologic and virologic responses to highly active antiretroviral therapy and subsequent disease progression among HIV-infected injection drug users. AIDS Care 2007, 19: 637-645. PMID: 17505924, DOI: 10.1080/09540120701235644.Peer-Reviewed Original ResearchConceptsInjection drug usersActive antiretroviral therapyRisk of progressionVirologic responseTreatment interruptionImmunologic responseAntiretroviral therapyCommunity-based injection drug usersDrug usersMultiple Cox regression analysisRecent outpatient visitYears of HAARTCox regression analysisInjection drug useNew AIDS diagnosesSubsequent disease progressionEarly responseHAART initiationHAART initiatorsHIV careOutpatient visitsCox regressionPrognostic valueAIDS diagnosisPoor response
2006
Physical activity in a cohort of HIV-positive and HIV-negative injection drug users
Smit E, Crespo C, Semba R, Jaworowicz D, Vlahov D, Ricketts E, Ramirez-Marrero F, Tang A. Physical activity in a cohort of HIV-positive and HIV-negative injection drug users. AIDS Care 2006, 18: 1040-1045. PMID: 17012097, DOI: 10.1080/09540120600580926.Peer-Reviewed Original ResearchConceptsInjection drug usersHIV-positive participantsHIV-positive injection drug usersInjection drug useHIV-negativeVigorous activityPhysical activityDrug usersDrug usePaffenbarger Physical Activity QuestionnaireRecent injection drug usersHIV-negative injection drug usersIntravenous Experience cohortActive antiretroviral therapyCohort of HIVHIV-negative participantsPhysical Activity QuestionnairePhysical activity levelsAntiretroviral therapyHIV infectionViral loadHIV treatmentActivity QuestionnaireAnthropometric measurementsEnergy expenditure
2005
Injection Drug Use Is an Independent Risk Factor for Iron Deficiency and Iron Deficiency Anemia Among HIV-Seropositive and HIV-Seronegative Women
Dancheck B, Tang A, Thomas A, Smit E, Vlahov D, Semba R. Injection Drug Use Is an Independent Risk Factor for Iron Deficiency and Iron Deficiency Anemia Among HIV-Seropositive and HIV-Seronegative Women. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 40: 198-201. PMID: 16186738, DOI: 10.1097/01.qai.0000165909.12333.07.Peer-Reviewed Original ResearchConceptsInjection drug useIron deficiency anemiaHepatitis C virus statusFemale injection drug usersC virus statusInjection drug usersDeficiency anemiaDrug useIron deficiencyRisk factorsVirus statusDrug usersMultivariate analysisInjection drug use historyCD4 lymphocyte countHIV-seronegative womenIndependent risk factorHIV-positive womenCross-sectional studyFurther longitudinal studiesNatural history studiesIntravenous Experience (ALIVE) studyDrug use historyHIV-seropositiveLymphocyte count
2003
Factors Associated With Human Herpesvirus Type 8 Infection in an Injecting Drug User Cohort
Bernstein K, Jacobson L, Jenkins F, Vlahov D, Armenian H. Factors Associated With Human Herpesvirus Type 8 Infection in an Injecting Drug User Cohort. Sexually Transmitted Diseases 2003, 30: 199-204. PMID: 12616135, DOI: 10.1097/00007435-200303000-00004.Peer-Reviewed Original ResearchConceptsHHV-8 seroprevalenceRisk factorsHHV-8Human herpesvirus type 8 infectionLarger body mass indexHuman herpesvirus type 8Drug user cohortHHV-8 seropositivityInjection drug useBody mass indexMultivariate logistic regressionCross-sectional studyDrug user populationGenital wartsMass indexGeneral populationDrug useSeroprevalenceIndirect immunofluorescenceLogistic regressionIDUsInfectionType 8User cohortSexual behaviorSocial Circumstances of Initiation of Injection Drug Use and Early Shooting Gallery Attendance: Implications for HIV Intervention Among Adolescent and Young Adult Injection Drug Users
Fuller C, Vlahov D, Latkin C, Ompad D, Celentano D, Strathdee S. Social Circumstances of Initiation of Injection Drug Use and Early Shooting Gallery Attendance: Implications for HIV Intervention Among Adolescent and Young Adult Injection Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2003, 32: 86. PMID: 12514419, DOI: 10.1097/00126334-200301010-00013.Peer-Reviewed Original ResearchConceptsInjection drug usersNew injection drug usersOlder injection drug usersYoung adult injection drug usersDrug usersHigh-risk injection drug usersStreet-recruited injection drug usersAdult injection drug usersYoung injection drug usersGallery attendanceProspective cohort studyInjection drug useMultiple logistic regressionHigh-risk practicesCohort studyMedian ageHIV incidenceHIV prevalenceInnovative intervention strategiesHIV interventionsDrug useLogistic regressionHIVBaseline dataMost participants
2002
High-risk behaviors associated with transition from illicit non-injection to injection drug use among adolescent and young adult drug users: a case-control study
Fuller C, Vlahov D, Ompad D, Shah N, Arria A, Strathdee S. High-risk behaviors associated with transition from illicit non-injection to injection drug use among adolescent and young adult drug users: a case-control study. Drug And Alcohol Dependence 2002, 66: 189-198. PMID: 11906806, DOI: 10.1016/s0376-8716(01)00200-9.Peer-Reviewed Original ResearchConceptsInjection drug usersInjection drug useAge-matched case-control analysisDrug usersDrug useBlood-borne infectionsAge-matched personsCase-control studyConditional logistic regressionCase-control analysisHigh-risk behaviorsNon-injection heroinCharacteristics of personsHIV seroprevalenceCohort studyInjection useAdult drug usersLogistic regressionPrevention effortsSame calendar timeYoung adult drug usersCalendar timePrior yearAfrican AmericansBaseline
2001
Cancer incidence in women with or at risk for HIV
Phelps R, Smith D, Heilig C, Gardner L, Carpenter C, Klein R, Jamieson D, Vlahov D, Schuman P, Holmberg S, Group S. Cancer incidence in women with or at risk for HIV. International Journal Of Cancer 2001, 94: 753-757. PMID: 11745473, DOI: 10.1002/ijc.1528.Peer-Reviewed Original ResearchConceptsInvasive cervical cancerLung cancerHigh-risk human immunodeficiency virusRace-matched womenCurrent antiretroviral therapyHistory of smokingMonths of diagnosisInjection drug useHuman immunodeficiency virusHIV Epidemiology Research StudyCare of womenRates of cancerCancer incidence dataInterval diagnosisUninfected womenAntiretroviral therapyHIV infectionStudy closureCervical cancerImmunodeficiency virusYoung smokersHodgkin's lymphomaMedical recordsCancer incidenceKaposi's sarcomaIsoniazid Preventive Therapy, Hepatitis C Virus Infection, and Hepatotoxicity among Injection Drug Users Infected with Mycobacterium tuberculosis
Sadaphal P, Astemborski J, Graham N, Sheely L, Bonds M, Madison A, Vlahov D, Thomas D, Sterling T. Isoniazid Preventive Therapy, Hepatitis C Virus Infection, and Hepatotoxicity among Injection Drug Users Infected with Mycobacterium tuberculosis. Clinical Infectious Diseases 2001, 33: 1687-1691. PMID: 11641824, PMCID: PMC2650436, DOI: 10.1086/323896.Peer-Reviewed Original ResearchConceptsHepatitis C virusInjection drug usersTuberculosis infectionValue elevationDrug usersCurrent injection drug useLatent Mycobacterium tuberculosis infectionHepatitis C virus infectionHepatitis B surface antigenLow HCV prevalenceC virus infectionIsoniazid preventive therapyInjection drug useM. tuberculosis infectionMycobacterium tuberculosis infectionHIV-1 infectionHuman immunodeficiency virusB surface antigenConcurrent alcohol useDrug discontinuationHCV prevalencePreventive therapyImmunodeficiency virusProspective studyTransaminase valuesInfluence of Injection Drug Use Behavior on Reported Antiretroviral Therapy Use Among Women in the HIV Epidemiology Research Study: On-Site Versus Referral Care.
Rompalo A, Shah N, Mayer K, Schuman P, Klein R, Smith D, Vlahov D. Influence of Injection Drug Use Behavior on Reported Antiretroviral Therapy Use Among Women in the HIV Epidemiology Research Study: On-Site Versus Referral Care. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2001, 28: 28. PMID: 11579274, DOI: 10.1097/00042560-200109010-00005.Peer-Reviewed Original ResearchConceptsInjection drug useInjection drug usersAntiretroviral therapy useAntiretroviral therapyART useDrug usersDrug useHIV careTherapy useSelf-reported injection drug useMedical careCD4 cell count categorySelf-reported ART useActive injection drug usersSexual contactFemale injection drug usersInjection drug use behaviorsPneumocystis carinii prophylaxisActive antiretroviral therapyProspective cohort studyHIV Epidemiology Research StudyHealth care providersCross-sectional analysisDrug use behaviorsReferral careInfluence of Injection Drug Use Behavior on Reported Antiretroviral Therapy Use Among Women in the HIV Epidemiology Research Study: On-Site Versus Referral Care
Rompalo A, Shah N, Mayer K, Schuman P, Klein R, Smith D, Vlahov D. Influence of Injection Drug Use Behavior on Reported Antiretroviral Therapy Use Among Women in the HIV Epidemiology Research Study: On-Site Versus Referral Care. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2001, 28: 28-34. DOI: 10.1097/00126334-200109010-00005.Peer-Reviewed Original ResearchInjection drug useInjection drug usersAntiretroviral therapy useAntiretroviral therapyART useDrug usersDrug useHIV careTherapy useSelf-reported injection drug useMedical careCD4 cell count categorySelf-reported ART useActive injection drug usersSexual contactFemale injection drug usersInjection drug use behaviorsPneumocystis carinii prophylaxisActive antiretroviral therapyProspective cohort studyHIV Epidemiology Research StudyHealth care providersCross-sectional analysisDrug use behaviorsReferral careSex Differences in Risk Factors for HIV Seroconversion Among Injection Drug Users: A 10-Year Perspective
Strathdee S, Galai N, Safaiean M, Celentano D, Vlahov D, Johnson L, Nelson K. Sex Differences in Risk Factors for HIV Seroconversion Among Injection Drug Users: A 10-Year Perspective. JAMA Internal Medicine 2001, 161: 1281-1288. PMID: 11371255, DOI: 10.1001/archinte.161.10.1281.Peer-Reviewed Original ResearchConceptsInjection drug usersIncidence of HIVHIV seroconversionRisk factorsProspective studyDrug usersHigh-risk heterosexual activityHuman immunodeficiency virus interventionsHIV-negative injection drug usersHuman immunodeficiency virus (HIV) infectionFemale injection drug usersImmunodeficiency virus infectionInjection drug useDrug-related risksHomosexual activityTime-dependent covariatesHIV testMedian agePerson yearsDaily injectionsNeedle sharingCocaine injectionHIV riskVirus infectionSeroconversionBlood-Borne and Sexual Transmission of Human Herpesvirus 8 in Women with or at Risk for Human Immunodeficiency Virus Infection
Cannon M, Dollard S, Smith D, Klein R, Schuman P, Rich J, Vlahov D, Pellett P. Blood-Borne and Sexual Transmission of Human Herpesvirus 8 in Women with or at Risk for Human Immunodeficiency Virus Infection. New England Journal Of Medicine 2001, 344: 637-643. PMID: 11228278, DOI: 10.1056/nejm200103013440904.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBlood-Borne PathogensFemaleHepatitis, Viral, HumanHerpesviridae InfectionsHerpesvirus 8, HumanHeterosexualityHIV InfectionsHumansLogistic ModelsProspective StudiesRisk FactorsRisk-TakingSeroepidemiologic StudiesSexual BehaviorSubstance Abuse, IntravenousSyphilisConceptsInjection drug useHHV-8 infectionHepatitis B virusHepatitis C virusHuman immunodeficiency virusHHV-8 seroprevalenceHHV-8Human herpesvirus 8Sexual transmissionRisk factorsHerpesvirus 8Human immunodeficiency virus (HIV) infectionHHV-8 seropositivityHigh-risk sexual behaviorImmunodeficiency virus infectionBlood-borne transmissionDaily injection drug useHispanic ethnic backgroundEnzyme-linked immunosorbentRisk of seropositivityBlood borneSyphilis infectionHIV infectionIndependent predictorsImmunodeficiency virusFactors Associated with Adolescent Initiation of Injection Drug Use
Fuller C, Vlahov D, Arria A, Ompad D, Garfein R, Strathdee S. Factors Associated with Adolescent Initiation of Injection Drug Use. Public Health Reports 2001, 116: 136-145. PMID: 11889281, PMCID: PMC1913680, DOI: 10.1093/phr/116.s1.136.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAdultAge FactorsBaltimoreBlack or African AmericanCommunity-Institutional RelationsFemaleHealth BehaviorHepatitis CHIV InfectionsHumansLogistic ModelsMalePrimary PreventionProspective StudiesRisk AssessmentRisk-TakingSexual BehaviorSubstance Abuse, IntravenousConceptsInjection drug useDrug useMedian ageInitiation of injectionCrack smokingNon-injection drug useAdolescent initiationHigh-risk groupYears of ageIllicit drug useAfrican AmericansDrug use practicesStudy enrollmentPrevents onsetEarly prevention effortsDrug usersMultivariate analysisCocaine useCondom useSmoking marijuanaLogistic regressionYoung drug usersPrevention effortsYoung adulthoodSmoking
2000
The prevalence of homelessness among injection drug users with and without HIV infection
Song J, Safaeian M, Strathdee S, Vlahov D, Celentano D. The prevalence of homelessness among injection drug users with and without HIV infection. Journal Of Urban Health 2000, 77: 678-687. PMID: 11194310, PMCID: PMC3456762, DOI: 10.1007/bf02344031.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusInjection drug usersInjection drug useIndependent predictorsDrug usersDrug useActive injection drug useLongitudinal cohort studyCross-sectional studyHIV/AIDSCross-sectional investigationHIV seroconversionCohort studyHIV seroprevalenceHIV infectionPrevalence of homelessnessImmunodeficiency virusMale sexLogistic regressionPrevalenceParticipantsMore experiencePredictorsSeroconversionSerostatusGender differences in the initiation of injection drug use among young adults
Doherty M, Garfein R, Monterroso E, Latkin C, Vlahov D. Gender differences in the initiation of injection drug use among young adults. Journal Of Urban Health 2000, 77: 396-414. PMID: 10976613, PMCID: PMC3456045, DOI: 10.1007/bf02386749.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusInjection drug useHIV risk profilesDrug useRisk behaviorsRisk profileLow HIV prevalenceInjection drug usersMale sex partnersCommunity-based recruitmentPercentage of womenMale IDUsHIV prevalenceImmunodeficiency virusRisky injectionMost womenGender differencesDrug usersSex partnersInjection initiationYoung womenPatterns of initiationNumber of personsYoung adultsWomenThe Natural History of Hepatitis C Virus Infection: Host, Viral, and Environmental Factors
Thomas D, Astemborski J, Rai R, Anania F, Schaeffer M, Galai N, Nolt K, Nelson K, Strathdee S, Johnson L, Laeyendecker O, Boitnott J, Wilson L, Vlahov D. The Natural History of Hepatitis C Virus Infection: Host, Viral, and Environmental Factors. JAMA 2000, 284: 450-456. PMID: 10904508, DOI: 10.1001/jama.284.4.450.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseInjection drug useHepatitis C virus infectionC virus infectionHuman immunodeficiency virusViral clearanceHCV infectionLiver diseaseDrug usePersistent viremiaVirus infectionCases of ESLDRisk of ESLDCommunity-based prospective cohort studyAntibody-positive test resultPresence of ascitesProspective cohort studyCause of deathUtilization of treatmentMajority of adultsSemiannual visitsCohort studyHCV RNAEsophageal varicesImmunodeficiency virusCorrelates of HIV infection among young adult short-term injection drug users
Doherty M, Garfein R, Monterroso E, Brown D, Vlahov D. Correlates of HIV infection among young adult short-term injection drug users. AIDS 2000, 14: 717-726. PMID: 10807195, DOI: 10.1097/00002030-200004140-00011.Peer-Reviewed Original ResearchConceptsInjection drug usersYoung injection drug usersInjection drug useHIV infectionDrug usersDrug useSpeedball injectionAnal sexCurrent injection drug usersShort-term injectorsReceptive anal sexYears of ageLifetime sex partnersCross-sectional surveySignificant bivariate associationsHIV incidenceHIV prevalenceSexual transmissionAmphetamine injectionsIncidence rateInjecting practicesHIVNew infectionsSex partnersInjection initiationDeterminants of the Quantity of Hepatitis C Virus RNA
Thomas D, Astemborski J, Vlahov D, Strathdee S, Ray S, Nelson K, Galai N, Nolt K, Laeyendecker O, Todd J. Determinants of the Quantity of Hepatitis C Virus RNA. The Journal Of Infectious Diseases 2000, 181: 844-851. PMID: 10720503, DOI: 10.1086/315314.Peer-Reviewed Original ResearchConceptsHCV RNA levelsHepatitis C virus RNAHIV-negative personsC virus RNAHCV RNARNA levelsLower HCV RNA levelsSerum HCV RNA levelsHepatitis B infectionInjection drug useHuman immunodeficiency virusVirus RNAVirologic factorsB infectionHCV infectionImmunodeficiency virusNeedle sharingBlood levelsPositive personsDrug useYounger ageInfectionEquivalents/Additional researchPerson variability
1999
Prevalence and Incidence of HIV Among Incarcerated and Reincarcerated Women in Rhode Island
Rich J, Dickinson B, Macalino G, Flanigan T, Towe C, Spaulding A, Vlahov D. Prevalence and Incidence of HIV Among Incarcerated and Reincarcerated Women in Rhode Island. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1999, 22: 161-166. PMID: 10843530, DOI: 10.1097/00126334-199910010-00008.Peer-Reviewed Original ResearchConceptsSelf-reported injection drug useIncidence of HIVInitiation of treatmentInjection drug useCase-control studySeronegative womenRecent temporal trendsHIV testHIV infectionHIV-positiveHIV prevalenceNonwhite raceRisk factorsAnnual prevalenceMandatory HIVHigh riskControl studyDrug useSexual riskHIVWomenPrevalencePrior incarcerationIncidenceIncarcerated womenPrevalence and Incidence of HIV Among Incarcerated and Reincarcerated Women in Rhode Island
Rich J, Dickinson B, Macalino G, Flanigan T, Towe C, Spaulding A, Vlahov D. Prevalence and Incidence of HIV Among Incarcerated and Reincarcerated Women in Rhode Island. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1999, 22: 161. DOI: 10.1097/00042560-199910010-00008.Peer-Reviewed Original ResearchSelf-reported injection drug useIncidence of HIVInitiation of treatmentInjection drug useCase-control studySeronegative womenRecent temporal trendsHIV testHIV infectionHIV-positiveHIV prevalenceNonwhite raceRisk factorsAnnual prevalenceMandatory HIVHigh riskControl studyDrug useSexual riskHIVWomenPrevalencePrior incarcerationIncidenceIncarcerated women