2000
Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10
Shin H, Winkler C, Stephens J, Bream J, Young H, Goedert J, O'Brien T, Vlahov D, Buchbinder S, Giorgi J, Rinaldo C, Donfield S, Willoughby A, O'Brien S, Smith M. Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 14467-14472. PMID: 11121048, PMCID: PMC18942, DOI: 10.1073/pnas.97.26.14467.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1 replicationTranscription factor recognition sequencePromoter allelesLong-term nonprogressorsHIV-1 pathogenesisSingle nucleotide polymorphic variantsOnset of AIDSMacrophages/monocytesNuclear transcription factorSignificant genotype associationsIL10 promoter regionShort tandem repeat polymorphismsTranscription factorsPromoter regionRecognition sequenceIL10 productionInflammatory cytokinesCell cytokinesAIDS cohortC genotypeLymphoid cellsPromoter genotypeGenetic restrictionLymphocyte replication
1999
Sex Differences in Longitudinal Human Immunodeficiency Virus Type 1 RNA Levels among Seroconverters
Sterling T, Lyles C, Vlahov D, Astemborski J, Margolick J, Quinn T. Sex Differences in Longitudinal Human Immunodeficiency Virus Type 1 RNA Levels among Seroconverters. The Journal Of Infectious Diseases 1999, 180: 666-672. PMID: 10438353, DOI: 10.1086/314967.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1 RNA levelsHIV-1 seroconvertersSex differencesCopies/mLHIV-1 pathogenesisInjection drug usersCase-control studyTime of seroconversionCross-sectional studyCourse of infectionMale patientsRapid progressorsFemale patientsCopies/Drug usersMale controlsVirus levelsPatientsRNA levelsSeroconvertersWomenMenNonprogressorsSeroconversionProgressors