2024
An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchConceptsYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive disorderCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual-patient data meta-analysisPosttreatment scoresEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusIndividual participant data meta-analysisSystematic reviewDisordersData meta-analysisPosttreatmentRemission definitionsImpressive improvement
2021
Psychophysiological assessment of stress reactivity and recovery in anxiety disorders
Tolin DF, Lee E, Levy HC, Das A, Mammo L, Katz BW, Diefenbach GJ. Psychophysiological assessment of stress reactivity and recovery in anxiety disorders. Journal Of Anxiety Disorders 2021, 82: 102426. PMID: 34022509, DOI: 10.1016/j.janxdis.2021.102426.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderCognitive behavioral therapyAnxiety disordersPanic disorderStressor phaseCBT outcomeHigh-frequency heart rate variabilityFrequency heart rate variabilityPsychophysiological reactivityEnd-tidal CODSM-5 anxiety disordersSpecialty outpatient clinicsHealthy control participantsHeart rate variabilityAdult patientsOutpatient clinicRate recoveryPatientsReactivity phaseResting phaseAnxious patientsAutonomic recoveryRate variabilityControl participantsDiminished changesVirtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders
Disorder W, Disorder A, Disorder B, Disorder M, Disorder O, Groups A, Patel Y, Parker N, Shin J, Howard D, French L, Thomopoulos S, Pozzi E, Abe Y, Abé C, Anticevic A, Alda M, Aleman A, Alloza C, Alonso-Lana S, Ameis S, Anagnostou E, McIntosh A, Arango C, Arnold P, Asherson P, Assogna F, Auzias G, Ayesa-Arriola R, Bakker G, Banaj N, Banaschewski T, Bandeira C, Baranov A, Bargalló N, Bau C, Baumeister S, Baune B, Bellgrove M, Benedetti F, Bertolino A, Boedhoe P, Boks M, Bollettini I, del Mar Bonnin C, Borgers T, Borgwardt S, Brandeis D, Brennan B, Bruggemann J, Bülow R, Busatto G, Calderoni S, Calhoun V, Calvo R, Canales-Rodríguez E, Cannon D, Carr V, Cascella N, Cercignani M, Chaim-Avancini T, Christakou A, Coghill D, Conzelmann A, Crespo-Facorro B, Cubillo A, Cullen K, Cupertino R, Daly E, Dannlowski U, Davey C, Denys D, Deruelle C, Di Giorgio A, Dickie E, Dima D, Dohm K, Ehrlich S, Ely B, Erwin-Grabner T, Ethofer T, Fair D, Fallgatter A, Faraone S, Fatjó-Vilas M, Fedor J, Fitzgerald K, Ford J, Frodl T, Fu C, Fullerton J, Gabel M, Glahn D, Roberts G, Gogberashvili T, Goikolea J, Gotlib I, Goya-Maldonado R, Grabe H, Green M, Grevet E, Groenewold N, Grotegerd D, Gruber O, Gruner P, Guerrero-Pedraza A, Gur R, Gur R, Haar S, Haarman B, Haavik J, Hahn T, Hajek T, Harrison B, Harrison N, Hartman C, Whalley H, Heslenfeld D, Hibar D, Hilland E, Hirano Y, Ho T, Hoekstra P, Hoekstra L, Hohmann S, Hong L, Höschl C, Høvik M, Howells F, Nenadic I, Jalbrzikowski M, James A, Janssen J, Jaspers-Fayer F, Xu J, Jonassen R, Karkashadze G, King J, Kircher T, Kirschner M, Koch K, Kochunov P, Kohls G, Konrad K, Krämer B, Krug A, Kuntsi J, Kwon J, Landén M, Landrø N, Lazaro L, Lebedeva I, Leehr E, Lera-Miguel S, Lesch K, Lochner C, Louza M, Luna B, Lundervold A, MacMaster F, Maglanoc L, Malpas C, Portella M, Marsh R, Martyn F, Mataix-Cols D, Mathalon D, McCarthy H, McDonald C, McPhilemy G, Meinert S, Menchón J, Minuzzi L, Mitchell P, Moreno C, Morgado P, Muratori F, Murphy C, Murphy D, Mwangi B, Nabulsi L, Nakagawa A, Nakamae T, Namazova L, Narayanaswamy J, Jahanshad N, Nguyen D, Nicolau R, Tuura R, O'Hearn K, Oosterlaan J, Opel N, Ophoff R, Oranje B, de la Foz V, Overs B, Paloyelis Y, Pantelis C, Parellada M, Pauli P, Picó-Pérez M, Picon F, Piras F, Piras F, Plessen K, Pomarol-Clotet E, Preda A, Puig O, Quidé Y, Radua J, Ramos-Quiroga J, Rasser P, Rauer L, Reddy J, Redlich R, Reif A, Reneman L, Repple J, Retico A, Richarte V, Richter A, Rosa P, Rubia K, Hashimoto R, Sacchet M, Salvador R, Santonja J, Sarink K, Sarró S, Satterthwaite T, Sawa A, Schall U, Schofield P, Schrantee A, Seitz J, Serpa M, Setién-Suero E, Shaw P, Shook D, Silk T, Sim K, Simon S, Simpson H, Singh A, Skoch A, Skokauskas N, Soares J, Soreni N, Soriano-Mas C, Spalletta G, Spaniel F, Lawrie S, Stern E, Stewart S, Takayanagi Y, Temmingh H, Tolin D, Tomecek D, Tordesillas-Gutiérrez D, Tosetti M, Uhlmann A, van Amelsvoort T, van der Wee N, van der Werff S, van Haren N, van Wingen G, Vance A, Vázquez-Bourgon J, Vecchio D, Venkatasubramanian G, Vieta E, Vilarroya O, Vives-Gilabert Y, Voineskos A, Völzke H, von Polier G, Walton E, Weickert T, Weickert C, Weideman A, Wittfeld K, Wolf D, Wu M, Yang T, Yang K, Yoncheva Y, Yun J, Cheng Y, Zanetti M, Ziegler G, Franke B, Hoogman M, Buitelaar J, van Rooij D, Andreassen O, Ching C, Veltman D, Schmaal L, Stein D, van den Heuvel O, Turner J, van Erp T, Pausova Z, Thompson P, Paus T. Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders. JAMA Psychiatry 2021, 78: 47-63. PMID: 32857118, PMCID: PMC7450410, DOI: 10.1001/jamapsychiatry.2020.2694.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderBipolar DisorderCase-Control StudiesCerebral CortexChildChild, PreschoolCohort StudiesComputational BiologyDepressive Disorder, MajorFemaleFetal DevelopmentGene ExpressionHuman DevelopmentHumansMagnetic Resonance ImagingMaleMiddle AgedObsessive-Compulsive DisorderPrincipal Component AnalysisSchizophreniaYoung Adult
2017
A Multisite Benchmarking Trial of Capnometry Guided Respiratory Intervention for Panic Disorder in Naturalistic Treatment Settings
Tolin DF, McGrath PB, Hale LR, Weiner DN, Gueorguieva R. A Multisite Benchmarking Trial of Capnometry Guided Respiratory Intervention for Panic Disorder in Naturalistic Treatment Settings. Applied Psychophysiology And Biofeedback 2017, 42: 51-58. PMID: 28194546, PMCID: PMC5344940, DOI: 10.1007/s10484-017-9354-4.Peer-Reviewed Original ResearchConceptsPanic disorderRespiratory interventionsTreatment settingsTreatment of PDGlobal illness severityTreat response rateNaturalistic treatment settingEnd-tidal CO2Normocapnic rangeRemission rateIllness severityPresent studyClinical resultsFunctional impairmentRepresentative patientsResponse rateClinical settingSimilar outcomesHypocapnic rangeSimilar decreasePanic severityInterventionHome useCliniciansClient adherence
2016
RANDOMIZED TRIAL OF D‐CYCLOSERINE ENHANCEMENT OF COGNITIVE‐BEHAVIORAL THERAPY FOR PANIC DISORDER
Otto MW, Pollack MH, Dowd SM, Hofmann SG, Pearlson G, Szuhany KL, Gueorguieva R, Krystal JH, Simon NM, Tolin DF. RANDOMIZED TRIAL OF D‐CYCLOSERINE ENHANCEMENT OF COGNITIVE‐BEHAVIORAL THERAPY FOR PANIC DISORDER. Depression And Anxiety 2016, 33: 737-745. PMID: 27315514, PMCID: PMC5958622, DOI: 10.1002/da.22531.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBenzodiazepine usePanic disorderDCS augmentationMulticenter trialD-cycloserineRecent multicenter trialPanic Disorder Severity ScaleExposure-based cognitive-behavioral therapySessions of treatmentStudy pillsPrimary outcomeRandomized trialsBaseline severityPrimary diagnosisAugmentation effectTreatment responseTreatment endpointBooster sessionsSeverity ScaleRole of severityBehavioral therapyDCS efficacyBeneficial effectsPilot studyPsychometric Properties of a Structured Diagnostic Interview for DSM-5 Anxiety, Mood, and Obsessive-Compulsive and Related Disorders
Tolin DF, Gilliam C, Wootton BM, Bowe W, Bragdon LB, Davis E, Hannan SE, Steinman SA, Worden B, Hallion LS. Psychometric Properties of a Structured Diagnostic Interview for DSM-5 Anxiety, Mood, and Obsessive-Compulsive and Related Disorders. Assessment 2016, 25: 3-13. PMID: 26988404, DOI: 10.1177/1073191116638410.Peer-Reviewed Original ResearchConceptsSelf-report measuresDiagnostic InterviewSymptoms of anxietyDSM-5 AnxietyDSM-5 disordersTest-retest reliability dataTest-retest reliabilityObsessive-CompulsiveConvergent validityPsychometric propertiesAnxietyMoodRelated disordersInterrater reliability dataGroup comparisonsNeuropsychiatric disorders
2015
Hoarding and emotional reactivity: The link between negative emotional reactions and hoarding symptomatology
Shaw A, Timpano K, Steketee G, Tolin D, Frost R. Hoarding and emotional reactivity: The link between negative emotional reactions and hoarding symptomatology. Journal Of Psychiatric Research 2015, 63: 84-90. PMID: 25732668, PMCID: PMC4387091, DOI: 10.1016/j.jpsychires.2015.02.009.Peer-Reviewed Original ResearchConceptsGeneral emotional reactivityEmotional reactivityNegative emotional reactionsEmotional reactionsIntense negative emotional reactionsCognitive-behavioral modelIntense negative emotionsIntense emotional reactionsCo-occurring moodExcessive acquiringCognitive factorsProcessing emotionsNegative emotionsEmotional filmsDifficulty discardingAnxiety symptomsAnalog samplesSymptom provocationBrain regionsMemoryEmotionsCurrent studyFearParticipantsHD etiology
2006
Sex Differences in Trauma and Posttraumatic Stress Disorder: A Quantitative Review of 25 Years of Research
Tolin DF, Foa EB. Sex Differences in Trauma and Posttraumatic Stress Disorder: A Quantitative Review of 25 Years of Research. Psychological Bulletin 2006, 132: 959-992. PMID: 17073529, DOI: 10.1037/0033-2909.132.6.959.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderFemale participantsGreater posttraumatic stress disorderChild sexual abuseMale participantsSex differencesSpecific PTEsNonsexual assaultTraumatic eventsPTSD riskSexual abuseSexual assaultParticipantsQuantitative reviewAssaultYears of researchDisordersPTEsAbuseParticular typeVictimsCombatTraumaDifferences
2003
Thought control strategies in obsessive-compulsive disorder: a replication and extension
Abramowitz J, Whiteside S, Kalsy S, Tolin D. Thought control strategies in obsessive-compulsive disorder: a replication and extension. Behaviour Research And Therapy 2003, 41: 529-540. PMID: 12711262, DOI: 10.1016/s0005-7967(02)00026-8.Peer-Reviewed Original Research
2001
Fixity of belief, perceptual aberration, and magical ideation in obsessive–compulsive disorder
Tolin D, Abramowitz J, Kozak M, Foa E. Fixity of belief, perceptual aberration, and magical ideation in obsessive–compulsive disorder. Journal Of Anxiety Disorders 2001, 15: 501-510. PMID: 11764309, DOI: 10.1016/s0887-6185(01)00078-0.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMagical ideationPerceptual distortionStandard cognitive behavioral therapyReligious obsessionsPsychotic-like featuresCognitive behavioral therapyTypes of obsessionsPsychotic-like symptomsPerceptual AberrationDistressing obsessionsOCD severityOCD patientsPoor insightMere differencePrevious findingsObsessionPsychotic symptomsIdeationBeliefsParticipantsIndividualsMore researchTreatment outcomesDisordersMemory and memory confidence in obsessive–compulsive disorder
Tolin D, Abramowitz J, Brigidi B, Amir N, Street G, Foa E. Memory and memory confidence in obsessive–compulsive disorder. Behaviour Research And Therapy 2001, 39: 913-927. PMID: 11480832, DOI: 10.1016/s0005-7967(00)00064-4.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMemory confidenceAnxious controlsNonanxious controlsMemory accuracyPrimary checkingThreat-related stimuliLong-term memoryLow confidenceSuch deficitsPathological doubtMemory deficitsSame stimuliGroup differencesOCDMemoryUnsafe objectsStimuliPrevious researchSet of objectsDeficitsEmpirical evidenceIndividualsConfidenceObjects
2000
Disgust sensitivity and contamination fears in spider and blood–injection–injury phobias
Sawchuk C, Lohr J, Tolin D, Lee T, Kleinknecht R. Disgust sensitivity and contamination fears in spider and blood–injection–injury phobias. Behaviour Research And Therapy 2000, 38: 753-762. PMID: 10937424, DOI: 10.1016/s0005-7967(99)00093-5.Peer-Reviewed Original ResearchConceptsContamination fearDisgust sensitivityBII phobicsSpider phobicsDisgust-evoking stimuliFear of contaminationElevated disgust sensitivityDisgust responsesSpider phobiaPhobic concernsPhobic stimuliFear measuresAnimal phobiasInjury phobiaSpecific phobicsPhobicsFear ScalePhobiaFearNonphobicsStimuliMeasuresElevated sensitivityDisgustPresent studyComparison of the PTSD symptom scale–interview version and the clinician‐administered PTSD scale
Foa E, Tolin D. Comparison of the PTSD symptom scale–interview version and the clinician‐administered PTSD scale. Journal Of Traumatic Stress 2000, 13: 181-191. PMID: 10838669, DOI: 10.1023/a:1007781909213.Peer-Reviewed Original ResearchConceptsClinician-Administered PTSD ScalePosttraumatic stress disorderCivilian trauma survivorsPTSD ScaleAssessment timeAssessment of PTSDStructured Clinical InterviewPTSD Symptom Scale-Interview VersionTrauma survivorsPsychometric propertiesPTSD Symptom ScaleNonveteran populationsIndependent cliniciansClinical InterviewSymptom ScaleSeparate interviewersDSM-IVHigh internal consistencyStress disorderPTSD severityLong assessment timeInterrater reliabilityInterview versionInternal consistencySurvivors
1999
Exposure to disgust-evoking imagery and information processing biases in blood-injection-injury phobia
Sawchuk C, Lohr J, Lee T, Tolin D. Exposure to disgust-evoking imagery and information processing biases in blood-injection-injury phobia. Behaviour Research And Therapy 1999, 37: 249-257. PMID: 10087643, DOI: 10.1016/s0005-7967(98)00127-2.Peer-Reviewed Original ResearchConceptsInformation processing biasesProcessing biasesBII phobiaBII phobicsInjury phobiaAnxiety disordersImplicit memory tasksThreat-relevant informationDisgust wordsAttentional biasImplicit memoryMemory taskStroop taskMood inductionBiased processingMemory processesNonphobic participantsCentral constructInformation processingPhobiaContemporary theoriesPhobicsBiasesMemoryWordsVisual avoidance in specific phobia
Tolin D, Lohr J, Lee T, Sawchuk C. Visual avoidance in specific phobia. Behaviour Research And Therapy 1999, 37: 63-70. PMID: 9922558, DOI: 10.1016/s0005-7967(98)00111-9.Peer-Reviewed Original ResearchConceptsCognitive modelVisual avoidanceThreat-relevant stimuliSubsequent recognition testExposure-based therapyPhobia-relevant stimuliInjury phobicsNeutral picturesSpider phobicsNeutral photographsNonphobic participantsRecognition testPhobic subjectsSpecific phobiaExperimenter's instructionsSpecific phobicsAnxiety disordersPhobicsAnxietyAvoidanceStimuliPhobiaTachistoscopePictureFear
1997
Disgust and disgust sensitivity in blood-injection-injury and spider phobia
Tolin D, Lohr J, Sawchuk C, Lee T. Disgust and disgust sensitivity in blood-injection-injury and spider phobia. Behaviour Research And Therapy 1997, 35: 949-953. PMID: 9401135, DOI: 10.1016/s0005-7967(97)00048-x.Peer-Reviewed Original ResearchConceptsSpider phobicsBII phobicsSpecific phobiaPictures of spidersRole of disgustCombination of fearInjury phobicsDisgust sensitivityPhobic participantsSpider phobiaDisgust ScaleMedical stimuliEmotional factorsPhobicsDisgustPhobiaFearCurrent theoriesNonphobicsSpecific objectsMotoric reactionsQuestionnaire dataStimuliEmotionsPresent study
1996
A large sample empirical typology of male spouse abusers and its relationship to dimensions of abuse.
Hamberger L, Lohr J, Bonge D, Tolin D. A large sample empirical typology of male spouse abusers and its relationship to dimensions of abuse. Violence And Victims 1996, 11: 277-92. PMID: 9210273, DOI: 10.1891/0886-6708.11.4.277.Peer-Reviewed Original ResearchConceptsHoltzworth-MunroePolice contactDimensions of abuseViolence severityViolent menAbusive menViolenceEmpirical typologyIntimate relationshipsMale spouse abusersMethodological implicationsSpouse abusersAntisocial menTypologyThree-cluster solutionStuart modelMenAbuseRelationshipImplicationsAntisocialAbusersCluster analysisNumber of studiesDimensions
1995
The empirical status of the clinical application of eye movement desensitization and reprocessing
Lohr J, Kleinknecht R, Tolin D, Barrett R. The empirical status of the clinical application of eye movement desensitization and reprocessing. Journal Of Behavior Therapy And Experimental Psychiatry 1995, 26: 285-302. PMID: 8675716, DOI: 10.1016/0005-7916(95)00041-0.Peer-Reviewed Original ResearchConceptsEye movement desensitizationClinical applicationEffect of treatmentClinical problemClassification of disordersClinical disordersNonspecific effectsPsychophysiologic measuresEye movementsTreatment fidelityComparative effectsTreatmentIndependent observer ratingsDesensitizationDisordersBehavioral indicesSingle-subject experimentsReportMethodological controlsEye movement desensitization of medical phobias: Two case studies
Lohr J, Tolin D, Kleinknecht R. Eye movement desensitization of medical phobias: Two case studies. Journal Of Behavior Therapy And Experimental Psychiatry 1995, 26: 141-151. PMID: 7593687, DOI: 10.1016/0005-7916(95)00011-n.Peer-Reviewed Original Research