2024
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Rivero R, Stitelman D. Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery. Current Stem Cell Reports 2024, 10: 51-57. DOI: 10.1007/s40778-024-00237-8.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaDiaphragmatic herniaAnimal modelsIntra-amniotic injectionLong-term functional outcomeParticle-based deliveryFetal therapyPrenatal therapySpinal defectsTarget specific tissuesCo-morbiditiesCongenital diseaseFunctional outcomesTreatment deliveryStructural diseaseClinical translationMyelomeningoceleTherapyHerniaSpecific tissuesTissueDiseaseDeliveryPrenatallyParticle deliveryThe Technical and Ethical Framework of Fetal Therapy: Past and Current Advances
Lynn A, Glazer P, Saltzman W, Stitelman D. The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances. Current Stem Cell Reports 2024, 10: 30-36. DOI: 10.1007/s40778-024-00235-w.Peer-Reviewed Original ResearchFetal drug deliverySuccess of nanomedicineDrug deliveryPharmacological drug treatmentsMinimally invasive strategyFetal therapyFetal applicationsClinical studiesCongenital diseaseInvasive strategyDrug treatmentClinical translationClinical practiceTherapyMedical interventionsDeliveryFetalNanomedicineBirthDiseaseFindingsAClinicians
2023
Ovarian Leydig Cell Tumor Associated with Recurrent Torsion and Virilization in an Adolescent Patient
Roth L, Smith A, Buza N, Coons B, Stitelman D, Vash-Margita A. Ovarian Leydig Cell Tumor Associated with Recurrent Torsion and Virilization in an Adolescent Patient. Journal Of Pediatric And Adolescent Gynecology 2023, 37: 217-219. PMID: 38110028, DOI: 10.1016/j.jpag.2023.11.014.Peer-Reviewed Original ResearchPolycystic ovarian syndromeOvarian tumorsCell tumorsRecurrent ovarian torsionAbnormal uterine bleedingPost-menopausal womenLeydig cell tumorUterine bleedingOvarian syndromeOvarian torsionYounger patientsOvarian functionOvarian hilumAdolescent patientsNodular proliferationSecrete androgensTumor AssociatedRecurrent torsionPrimary amenorrheaCurrent recommendationsReinke crystalsTumorsLeydig cellsIncidence increasesVirilizationIn utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia
Ullrich S, Yung N, Bauer-Pisani T, Maassel N, Guerra M, Freedman-Weiss M, Ahle S, Ricciardi A, Sauler M, Saltzman W, Piotrowski-Daspit A, Stitelman D. In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia. Molecular Therapy - Nucleic Acids 2023, 32: 594-602. PMID: 37200861, PMCID: PMC10185702, DOI: 10.1016/j.omtn.2023.04.018.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaTGF-β pathwayDiaphragmatic herniaFetal ratsPulmonary vascular remodelingLung function resultsGestational day 18Pre-clinical modelsDifferent gestational timesCritical illnessPulmonary pathologyLung growthLung sizeRat modelFetal casesLung morphologyVascular remodelingMicroRNA-200bVein injectionFetal diseaseFirst breathDay 18Lung developmentGestational timeInvasive fashion
2022
Cholecystitis and Gallstone Disease
Maassel N, Stitelman D. Cholecystitis and Gallstone Disease. 2022, 837-841. DOI: 10.1007/978-3-031-07524-7_90.Peer-Reviewed Original ResearchLow gallbladder ejection fractionLimited hospital stayMost surgical candidatesPediatric laparoscopic cholecystectomyAbsence of gallstonesGallbladder ejection fractionNuclear medicine scansTreatment of childrenBiliary colicBiliary dyskinesiaHospital stayComplicated cholecystitisSurgical candidatesEjection fractionGallstone diseaseLaparoscopic cholecystectomyMotility disordersBlood testsPhysical examinationChronic hemolytic diseaseHemolytic diseaseFocused historyPediatric specialistsObesity ratesCholecystitis
2021
The parental journey of fetal care: a systematic review and metasynthesis
Wilpers A, Bahtiyar MO, Stitelman D, Batten J, Calix RX, Chase V, Yung N, Maassel N, Novick G. The parental journey of fetal care: a systematic review and metasynthesis. American Journal Of Obstetrics & Gynecology MFM 2021, 3: 100320. PMID: 33493706, DOI: 10.1016/j.ajogmf.2021.100320.Peer-Reviewed Original ResearchNanoparticles for delivery of agents to fetal lungs
Ullrich SJ, Freedman-Weiss M, Ahle S, Mandl HK, Piotrowski-Daspit AS, Roberts K, Yung N, Maassel N, Bauer-Pisani T, Ricciardi AS, Egan ME, Glazer PM, Saltzman WM, Stitelman DH. Nanoparticles for delivery of agents to fetal lungs. Acta Biomaterialia 2021, 123: 346-353. PMID: 33484911, PMCID: PMC7962939, DOI: 10.1016/j.actbio.2021.01.024.Peer-Reviewed Original ResearchConceptsFetal lungCellular uptakeIntra-amniotic routeRoute of deliveryCongenital lung diseaseDelivery of agentsIntra-amniotic deliveryRelative cellular uptakeNanoparticlesFetal treatmentDiaphragmatic herniaLung diseaseFetal therapyLung tissueFetal miceIntravenous deliveryCystic fibrosisLungLung therapyInterventional technologiesTherapeutic agentsEndothelial cellsCell populationsEffective targetingTherapy
2020
Anomalies of the Gastrointestinal Tract
Rubinstein J, Farrelly J, Stitelman D, Christison-Lagay E. Anomalies of the Gastrointestinal Tract. 2020, 179-204. DOI: 10.1007/978-3-030-55660-0_9.ChaptersMinimally Invasive Fetal Therapy for Myelomeningocele
Freedman-Weiss M, Stitelman D. Minimally Invasive Fetal Therapy for Myelomeningocele. Current Stem Cell Reports 2020, 6: 1-5. DOI: 10.1007/s40778-020-00167-1.Peer-Reviewed Original ResearchNon-invasive therapeutic approachInvasive fetal therapyPostnatal surgical repairDevastating clinical manifestationsTissue engineeringScaffold-based tissue engineeringMedical managementSurgical repairCell-based therapiesClinical manifestationsFetal stem cellsCurrent therapiesPatient outcomesSpinal cordFetal therapyFetal surgeryTherapeutic approachesTherapyInvasive wayTranslational scienceStem cellsReview detailsParticle deliveryNovel scientific researchParticle injection
2019
An Evidence-Based Guideline Supporting Restricted Opioid Prescription after Pediatric Appendectomy
Freedman-Weiss MR, Chiu AS, Worhunsky D, Manchisi A, Torres-Maldonado I, Sagnella L, Caty MG, Cowles RA, Ozgediz DE, Christison-Lagay ER, Solomon DG, Stitelman DH. An Evidence-Based Guideline Supporting Restricted Opioid Prescription after Pediatric Appendectomy. Journal Of Pediatric Surgery 2019, 55: 106-111. PMID: 31699433, DOI: 10.1016/j.jpedsurg.2019.09.063.Peer-Reviewed Original ResearchConceptsLaparoscopic appendectomyOpioid prescriptionsPostoperative opioid needsPostoperative telephone interviewsQuantity of opioidsPresence of painYoung adult patientsEvidence-based guidelinesMain outcome measuresOpioid needsAnalgesic useModifiable contributorPain reliefAdequate analgesiaAdult patientsChart reviewHospital dischargeMost patientsPatients 5Pediatric appendectomyYounger patientsPain concernsAverage MMEOpioid epidemicOutcome measuresUtility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions
Tuzovic L, Copel JA, Stitelman DH, Levit O, Bahtiyar MO. Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions. Journal Of Ultrasound In Medicine 2019, 38: 2361-2372. PMID: 30653685, DOI: 10.1002/jum.14931.Peer-Reviewed Original ResearchConceptsAbnormal cardiac axisNegative predictive valueFetal cardiac axisNeonatal respiratory morbidityRespiratory morbidityCongenital lung lesionsCardiac positionPositive predictive valuePredictive valueCardiac axisLung lesionsHigh negative predictive valueSevere respiratory morbidityRetrospective cohort studyRight-sided lesionsNormal cardiac axisCohort studyWeeks' gestationMorbidityCP assessmentWeeksDiagnostic performanceLesionsPatientsGestation
2018
Opioid Prescribing Habits of General Versus Pediatric Surgeons After Uncomplicated Laparoscopic Appendectomy
Freedman-Weiss MR, Chiu A, Solomon DG, Christison-Lagay ER, Ozgediz DE, Cowles RA, Caty MG, Stitelman DH. Opioid Prescribing Habits of General Versus Pediatric Surgeons After Uncomplicated Laparoscopic Appendectomy. Journal Of Surgical Research 2018, 235: 404-409. PMID: 30691822, DOI: 10.1016/j.jss.2018.09.085.Peer-Reviewed Original ResearchConceptsOral morphine equivalentsUncomplicated laparoscopic appendectomyAmount of opioidsLaparoscopic appendectomyGeneral surgeonsPediatric surgeonsSurgery providersFuture drug abuseOpioid prescribing habitsPills of oxycodoneRetrospective chart reviewYoung adult patientsPrimary outcome measureType of analgesiaGeneral surgery servicePediatric laparoscopic appendectomyHigh-risk populationLength of stayCommon surgical procedureSingle health systemAge group 13More opioidsMorphine equivalentsModifiable contributorOpioid analgesiaRoutine postnatal chest x-ray and intensive care admission are unnecessary for a majority of infants with congenital lung malformations
Greig CJ, Keiser AM, Cleary MA, Stitelman DH, Christison-Lagay ER, Ozgediz DE, Solomon DG, Caty MG, Cowles RA. Routine postnatal chest x-ray and intensive care admission are unnecessary for a majority of infants with congenital lung malformations. Journal Of Pediatric Surgery 2018, 54: 670-674. PMID: 30503193, DOI: 10.1016/j.jpedsurg.2018.10.063.Peer-Reviewed Original ResearchConceptsAbnormal chest X-rayCongenital lung malformationsChest X-rayNICU admissionMajority of infantsRespiratory supportBirth weightGestational ageLung malformationsOdds ratioInitial symptomsNeonatal intensive care unit admissionInitial chest X-rayIntensive care unit admissionCare unit admissionIntensive care admissionLevel II evidenceDays of dischargeMajority of casesNICU stayROC cutoffUnit admissionCare admissionFuture care needsImmediate surgeryAlginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele
Farrelly JS, Bianchi AH, Ricciardi AS, Buzzelli GL, Ahle SL, Freedman-Weiss MR, Luks VL, Saltzman WM, Stitelman DH. Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele. Journal Of Pediatric Surgery 2018, 54: 80-85. PMID: 30414695, DOI: 10.1016/j.jpedsurg.2018.10.031.Peer-Reviewed Original ResearchConceptsSoft tissue coverageTissue coverageRat modelTime-dated pregnant ratsFree bFGFGrowth factorInjection of microparticlesBasic fibroblast growth factorFibroblast growth factorPregnant ratsPrenatal treatmentIntraamniotic injectionFetal myelomeningoceleMyelomeningoceleMMC coverageMMC defectsRetinoic acidBFGFIn utero nanoparticle delivery for site-specific genome editing
Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. In utero nanoparticle delivery for site-specific genome editing. Nature Communications 2018, 9: 2481. PMID: 29946143, PMCID: PMC6018676, DOI: 10.1038/s41467-018-04894-2.Peer-Reviewed Original ResearchConceptsSite-specific genome editingReversal of splenomegalyPeptide nucleic acidIntra-amniotic administrationBlood hemoglobin levelsMonogenic disordersNanoparticle deliveryPolymeric nanoparticlesPostnatal elevationGestational ageHemoglobin levelsImproved survivalPediatric morbidityDisease improvementHuman β-thalassemiaReticulocyte countNormal organ developmentMouse modelNormal rangeEarly interventionGenome editingOff-target mutationsPostnatal growthGene editingVersatile methodAn atypical case of megacystis microcolon intestinal hypoperistalsis syndrome with extended survival and consistent bowel function
Farrelly J, Weiss R, Copel J, Porto A, Ahle S, Luks V, McGrath J, Stitelman D. An atypical case of megacystis microcolon intestinal hypoperistalsis syndrome with extended survival and consistent bowel function. Journal Of Pediatric Surgery Case Reports 2018, 30: 48-51. DOI: 10.1016/j.epsc.2017.11.010.Peer-Reviewed Case Reports and Technical Notes
2017
Repair of a mycotic abdominal aortic aneurysm in a neonate using an everted jugular vein patch
Ahle SL, Cardella JA, Cleary MA, Stitelman DH, Sarac TP, Caty MG. Repair of a mycotic abdominal aortic aneurysm in a neonate using an everted jugular vein patch. Journal Of Vascular Surgery Cases And Innovative Techniques 2017, 3: 218-220. PMID: 29349429, PMCID: PMC5765176, DOI: 10.1016/j.jvscit.2017.08.003.Peer-Reviewed Original ResearchVein patchAortic aneurysmMycotic abdominal aortic aneurysmMycotic infrarenal aortic aneurysmRight common iliac arteryUmbilical artery catheterizationInfrarenal aortic aneurysmCommon iliac arteryDuplex ultrasound examinationAbdominal aortic aneurysmArtery catheterizationIliac arteryUltrasound examinationExamination 10Successful repairAneurysmsRepairCatheterizationBacteremiaResectionNeonatesArterySurgical tray optimization as a simple means to decrease perioperative costs
Farrelly JS, Clemons C, Witkins S, Hall W, Christison-Lagay ER, Ozgediz DE, Cowles RA, Stitelman DH, Caty MG. Surgical tray optimization as a simple means to decrease perioperative costs. Journal Of Surgical Research 2017, 220: 320-326. PMID: 29180198, DOI: 10.1016/j.jss.2017.06.029.Peer-Reviewed Original ResearchConceptsSurgery sectionSingle-site observational studyHealth care cost reductionLarge academic medical centerHospital cost reductionCare cost reductionAcademic medical centerSurgical tray optimizationSurgical traysStudy startHealth care spendingSpine surgeryObservational studySurgical sectionMedical CenterPediatric surgeryPediatric surgeonsPerioperative costsAcademic centersUrology SectionOperating room nursingMultidisciplinary teamPediatric urologyPediatric orthopedicsScrub technicians
2016
Complications in pediatric enteral and vascular access
Farrelly JS, Stitelman DH. Complications in pediatric enteral and vascular access. Seminars In Pediatric Surgery 2016, 25: 371-379. PMID: 27989361, DOI: 10.1053/j.sempedsurg.2016.10.006.Peer-Reviewed Original ResearchAcquired seminal vesicle cyst in a teenager with a urethral stricture of unknown etiology
Farrelly J, Cleary M, Weiss R, Morotti R, Stitelman D. Acquired seminal vesicle cyst in a teenager with a urethral stricture of unknown etiology. Journal Of Pediatric Surgery Case Reports 2016, 7: 8-12. DOI: 10.1016/j.epsc.2016.01.002.Peer-Reviewed Original ResearchSeminal vesicle cystUrethral strictureUpper urinary tract anatomyUpper urinary tract anomaliesLower urinary tract signsUrinary tract anatomyUrinary tract anomaliesUrinary tract signsUrethral inflammationTract anomaliesTract signsPediatric populationBulbar urethraRare diagnosisUnknown etiologyUrethral pathologyComplete resolutionYounger ageTract anatomyUnique caseCystsStrictureInflammationPatientsUrethra