2016
Biosimilar FSH preparations- are they identical twins or just siblings?
Orvieto R, Seifer DB. Biosimilar FSH preparations- are they identical twins or just siblings? Reproductive Biology And Endocrinology 2016, 14: 32. PMID: 27301324, PMCID: PMC4908720, DOI: 10.1186/s12958-016-0167-8.Peer-Reviewed Original ResearchMeSH KeywordsBiosimilar PharmaceuticalsFemaleFollicle Stimulating HormoneHumansPregnancyPregnancy RateRecombinant ProteinsTreatment OutcomeConceptsFSH preparationsPregnancy rateClinical practicePhase 3 clinical trialsIncidence of OHSSOngoing pregnancy ratePolycystic ovary syndromeAdditional patient populationsPopulation of womenDose-response curveRecombinant FSH preparationsBiosimilar productsNormal respondersIVF failurePoor respondersOvary syndromeClinical efficacyPatient populationClinical trialsBiosimilar agentsSteelman-PohleyClinical useFurther comparative studiesPatientsIdentical twins
2014
Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
Irani M, Minkoff H, Seifer DB, Merhi Z. Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e886-e890. PMID: 24606102, DOI: 10.1210/jc.2013-4374.Peer-Reviewed Original ResearchConceptsAdvanced glycation end productsPolycystic ovary syndromeAnti-Mullerian hormoneSerum anti-Mullerian hormoneGlycation end productsVitamin DSerum sRAGED3 supplementationDeficient womenAMH concentrationsVit D3Soluble receptorDeposition of AGEsAbnormal ovarian folliculogenesisDihydroxyvitamin D3 supplementationSerum sRAGE levelsVit D3 supplementationVitamin D supplementationSerum AMH levelsVitamin D deficiencyBody mass indexD supplementationAMH levelsD deficiencySRAGE levels
2004
Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol
Hazout A, Bouchard P, Seifer DB, Aussage P, Junca AM, Cohen-Bacrie P. Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol. Fertility And Sterility 2004, 82: 1323-1329. PMID: 15533354, DOI: 10.1016/j.fertnstert.2004.03.061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersEstradiolFemaleFertilization in VitroFollicle Stimulating HormoneGlycoproteinsHumansInhibinsMultivariate AnalysisOsmolar ConcentrationOvulation InductionPredictive Value of TestsPregnancyPregnancy RateRetrospective StudiesTesticular HormonesTime FactorsTreatment OutcomeConceptsReproductive technology outcomesMullerian-inhibiting substanceYears of ageMultivariate regression analysisInhibin BPregnancy outcomesIVF outcomesAntimullerian hormoneHigher clinical pregnancy rateSerum samplesAvailable serum markersDay 3 FSHSerum antimullerian hormoneClinical pregnancy rateClinical pregnancy outcomesInhibin B levelsFollicle-stimulating hormoneConsecutive serum samplesMüllerian-inhibiting substanceGreater prognostic valueTechnology outcomesRegression analysisClinical pregnancyOvarian stimulationOvulation induction
2003
In vitro fertilization in the older patient.
Derman SG, Seifer DB. In vitro fertilization in the older patient. Current Women'S Health Reports 2003, 3: 375-83. PMID: 12959695.Peer-Reviewed Original ResearchConceptsOlder patientsClomiphene citrate challenge testBasal follicle-stimulating hormoneAntral follicle countDiminished ovarian reserveLower oocyte yieldFollicle-stimulating hormoneHigher miscarriage rateMüllerian-inhibiting substanceHigher cancellation rateIVF success ratesLower pregnancy ratesFlare protocolInhibin BIVF patientsMiscarriage rateOvarian reserveOvarian volumeFollicle countGnRH antagonistOocyte yieldEstradiol levelsPregnancy rateAgonist doseStimulation protocolEffect of gonadotropins on brain-derived neurotrophic factor secretion by human follicular cumulus cells
Feng B, Chen S, Shelden RM, Seifer DB. Effect of gonadotropins on brain-derived neurotrophic factor secretion by human follicular cumulus cells. Fertility And Sterility 2003, 80: 658-659. PMID: 12969721, DOI: 10.1016/s0015-0282(03)00742-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain-Derived Neurotrophic FactorChorionic GonadotropinFemaleFollicle Stimulating HormoneGranulosa CellsHumansLuteinizing Hormone
2002
Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles
Seifer DB, MacLaughlin DT, Christian BP, Feng B, Shelden RM. Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles. Fertility And Sterility 2002, 77: 468-471. PMID: 11872196, DOI: 10.1016/s0015-0282(01)03201-0.Peer-Reviewed Original ResearchConceptsOvarian responseMIS concentrationsReproductive technology cyclesGreater serum concentrationsGroup of womenOvulation inductionSerum concentrationsMaximum serumRetrospective analysisMAIN OUTCOMESubstance levelsSerum MISSerum samplesMI levelsWomenMature oocytesTechnology cyclesReproductive technologiesOocytesSerumART programsGroupIVFGreater number
2001
Contribution of diminished ovarian reserve to hypofertility associated with endometriosis.
Hock DL, Sharafi K, Dagostino L, Kemmann E, Seifer DB. Contribution of diminished ovarian reserve to hypofertility associated with endometriosis. The Journal Of Reproductive Medicine 2001, 46: 7-10. PMID: 11209637.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesEmbryo TransferEndometriosisEstradiolFemaleFertilization in VitroFollicle Stimulating HormoneHumansInfertility, FemaleInfertility, MaleMaleOvaryConceptsStage III/IV endometriosisStage I/II endometriosisOvarian reserveFSH levelsFertilization/embryo transferHigh E2 levelsStage of endometriosisDay 3 levelsMale factor infertilityCase-control studyAge-matched controlsFactor infertilityE2 levelsEndometriosisEmbryo transferTotal groupProgressive lossControl levelsWomenSignificant differencesE2FSHLevelsPatientsInfertility
2000
Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle
Dzik A, Lambert-Messerlian G, Izzo V, Soares J, Pinotti J, Seifer D. Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle. Fertility And Sterility 2000, 74: 1114-1117. PMID: 11119736, DOI: 10.1016/s0015-0282(00)01627-7.Peer-Reviewed Original ResearchConceptsInhibin B levelsInhibin B serum levelsB levelsInhibin B responsesSubsequent IVF cycleLevels 24 hoursAcademic clinical practiceGood responsePg/mLGonadotropin challengeBaseline serumInhibin BIVF cyclesOvarian stimulationOocyte retrievalOvarian reserveFertilization cyclesOvarian responseSerum levelsPoor responseOdds ratioMAIN OUTCOMEClinical practiceCorresponding oddsPg/Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values?
Trout S, Seifer D. Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values? Fertility And Sterility 2000, 74: 335-337. PMID: 10927054, DOI: 10.1016/s0015-0282(00)00625-7.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, HabitualAdultCase-Control StudiesEstradiolFemaleFollicle Stimulating HormoneHumansMenstrual CycleOvaryPregnancyRetrospective StudiesConceptsDay 3 serum FSHRecurrent pregnancy lossUnexplained recurrent pregnancy lossCauses of RPLSerum FSHPregnancy lossControl groupOvarian reserveDay 3 FSHUnexplained habitual abortionDiminished ovarian reservePresence of infertilityHistory of infertilityRetrospective comparative analysisUnexplained groupRPL groupHabitual abortionMean ageMAIN OUTCOMEFSHGreater incidenceTest groupWomenPotential roleInfertility
1999
Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone
Seifer D, Scott R, Bergh P, Abrogast L, Friedman C, Mack C, Danforth D. Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone. Fertility And Sterility 1999, 72: 63-65. PMID: 10428149, DOI: 10.1016/s0015-0282(99)00193-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsCase-Control StudiesEstradiolFemaleFollicle Stimulating HormoneGonadotropinsHumansInfertilityInhibinsMenstrual CycleOvaryConceptsSerum inhibin B levelsInhibin B levelsDay 3 FSH levelsCycle cancellation rateClinical pregnancy rateSerum inhibin BOvarian reserveFSH levelsB levelsInhibin BPregnancy rateCancellation rateDay 3 follicle-stimulating hormoneDay 3 serum FSH levelsHigher cycle cancellation rateTertiary-care fertility centreNumber of ampulesSerum FSH levelsSerum FSH concentrationsFollicle-stimulating hormoneCase-control studyNumber of oocytesOvarian responsivenessFSH concentrationsGonadotropin requirements
1998
Oocyte loss and the perimenopause.
Bopp BL, Seifer DB. Oocyte loss and the perimenopause. Clinical Obstetrics & Gynecology 1998, 41: 898-911. PMID: 9917945, DOI: 10.1097/00003081-199812000-00016.Peer-Reviewed Original ResearchThe detection of diminished ovarian reserve in infertile women
Sharara F, Scott R, Seifer D. The detection of diminished ovarian reserve in infertile women. American Journal Of Obstetrics And Gynecology 1998, 179: 804-812. PMID: 9757994, DOI: 10.1016/s0002-9378(98)70087-0.Peer-Reviewed Original ResearchMeSH KeywordsAgingFemaleFertilization in VitroFollicle Stimulating HormoneHumansInfertility, FemaleOvaryOvulation InductionPregnancyPregnancy RateConceptsOvarian reserveOwn gametesDiminished ovarian reserveFetal cardiac activityLower chanceReproductive technologiesInfertility populationInfertile womenProvocative testsPregnancy lossPregnancy rateInvasive therapyHigh incidenceExpensive treatmentWomenCardiac activityLate 30sEarly 40sMultiple testingDaily challengesPregnancyUltrasonographyInfertilityTherapyCliniciansDimeric inhibin: a direct marker of ovarian aging
Danforth D, Arbogast L, Mroueh J, Kim M, Kennard E, Seifer D, Friedman C. Dimeric inhibin: a direct marker of ovarian aging. Fertility And Sterility 1998, 70: 119-123. PMID: 9660432, DOI: 10.1016/s0015-0282(98)00127-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersEstradiolFemaleFollicle Stimulating HormoneFollicular PhaseHumansInhibinsLuteal PhaseMenopauseMiddle AgedOvaryProgesteroneProspective StudiesReference ValuesConceptsInhibin B levelsPerimenopausal transitionOvarian reserveRegular menstrual cyclesPituitary FSH secretionDaily urine samplesSubsequent follicular phaseCorpus luteum functionYears of ageDay of ovulationWomen 39FSH levelsInhibin secretionFSH secretionPerimenopausal womenSerum levelsLH surgeProspective studyOvarian functionFollicular phaseMenstrual cycleFifth decadeMAIN OUTCOMEBlood samplesLuteal secretionEditorial
Seifer D, Naftolin F. Editorial. Fertility And Sterility 1998, 69: 387-388. PMID: 9531863, DOI: 10.1016/s0015-0282(97)00564-5.Peer-Reviewed Original ResearchInhibin-B: The Physiologic Basis of the Clomiphene Citrate Challenge Test for Ovarian Reserve Screening 1This work was supported by The Bethesda Foundation.1
Hofmann G, Danforth D, Seifer D. Inhibin-B: The Physiologic Basis of the Clomiphene Citrate Challenge Test for Ovarian Reserve Screening 1This work was supported by The Bethesda Foundation.1. Fertility And Sterility 1998, 69: 474-477. PMID: 9531880, DOI: 10.1016/s0015-0282(97)00531-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultClomipheneFemaleFollicle Stimulating HormoneGranulosa CellsHumansInfertility, FemaleInhibinsKineticsOvaryRetrospective StudiesConceptsClomiphene citrate challenge testInhibin B concentrationsNormal ovarian reserveDiminished ovarian reserveOvarian reserve screeningOvarian reserveDay 3Challenge testSerum inhibin B concentrationElevated FSH concentrationsTertiary fertility centerCycle day 3Cycle day 10Higher inhibin B concentrationsInhibin B productionFSH levelsFSH concentrationsFertility centerMAIN OUTCOMEPhysiologic basisFollicular apparatusDay 10WomenPatientsFertility evaluation
1997
Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome
Seifer D, Lambert-Messerlian G, Hogan J, Gárdiner A, Blazar A, Berk C. Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome. Fertility And Sterility 1997, 67: 110-114. PMID: 8986693, DOI: 10.1016/s0015-0282(97)81865-1.Peer-Reviewed Original ResearchConceptsClinical pregnancy rateNumber of oocytesSerum inhibin B concentrationPg/mLInhibin B concentrationsSerum inhibinPregnancy ratePg/Clinical pregnancyOvulation inductionSerum E2Poor responseCancellation rateDay 3 serum FSHAssisted reproductive technology cyclesGnRH agonist suppressionInhibin B valuesReproductive technology cyclesDay of hCGSpontaneous abortion rateAcademic clinical practiceReproductive technologiesSerum FSHOdds ratioE2 response
1996
Apoptosis as a function of ovarian reserve in women undergoing in vitro fertilization*†
Seifer D, Gardiner A, Ferreira K, Peluso J. Apoptosis as a function of ovarian reserve in women undergoing in vitro fertilization*†. Fertility And Sterility 1996, 66: 593-598. PMID: 8816622, DOI: 10.1016/s0015-0282(16)58573-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultApoptosisFemaleFertilization in VitroFlow CytometryFollicle Stimulating HormoneGranulosa CellsHumansOvaryConceptsDay 3 serum FSHFSH levelsOvarian reserveSerum FSHMIU/Granulosa cellsCell countDiminished ovarian reserveMIU/mLAcademic clinical practiceLuteinized granulosa cellsApoptotic granulosa cellsIVF-ETFollicular aspiratesPreovulatory folliclesClinical practiceFlow cytometryWomenMean numberApoptotic cellsFSHGreater percentageFolliclesCellsViable cellsDifferential secretion of dimeric inhibin in cultured luteinized granulosa cells as a function of ovarian reserve
Seifer DB, Gardiner AC, Lambert-Messerlian G, Schneyer AL. Differential secretion of dimeric inhibin in cultured luteinized granulosa cells as a function of ovarian reserve. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 736-739. PMID: 8636296, DOI: 10.1210/jcem.81.2.8636296.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedEstradiolFemaleFertilization in VitroFollicle Stimulating HormoneGranulosa CellsHumansImmunoassayInhibinsMacromolecular SubstancesOvaryProgesteroneProspective StudiesConceptsDay 3 serum FSHLuteinized granulosa cellsHigh FSH groupDimeric inhibinSerum FSHFSH groupPg/Granulosa cellsFSH levelsOvarian reserveOvulation inductionProgesterone concentrationsDay 3 serum FSH levelsCultured luteinized granulosa cellsDimeric inhibin productionLow FSH groupSerum FSH levelsFertilization-embryo transferHigher FSH levelsReproductive technology programGranulosa cell levelTotal inhibinInhibin concentrationsInhibin productionProspective study
1995
Endocrinology: Follicular fluid insulin-like growth factor-I and insulin-like growth factor-II concentrations vary as a function of day 3 serum follicle stimulating hormone*
Seifer DB, Giudice LC, Dsupin BA, Haning RV, Frishman GN, Burger HG. Endocrinology: Follicular fluid insulin-like growth factor-I and insulin-like growth factor-II concentrations vary as a function of day 3 serum follicle stimulating hormone*. Human Reproduction 1995, 10: 804-806. PMID: 7650124, DOI: 10.1093/oxfordjournals.humrep.a136042.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFertilization in VitroFollicle Stimulating HormoneFollicular FluidHumansInhibinsInsulin-Like Growth Factor IInsulin-Like Growth Factor IIOvulation InductionConceptsDay 3 serum follicleInsulin-like growth factorFollicular fluid concentrationsFSH groupSerum follicleIGF-IIGrowth factorFollicular fluid insulin-like growth factorMean IGF-II concentrationsFluid concentrationsMean IGF-I concentrationInsulin-like growth factor II concentrationsDay 3 FSHFollicular fluid IGFIGF-II concentrationsIGF-I concentrationsFactor II concentrationsFollicular fluid aspirationInhibin concentrationsFluid aspirationEmbryo transferFolliclesIGFHormoneGroup
1994
Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist-induced suppression is associated with impaired implantation**Presented at the 48th Annual Meeting of The American Fertility Society, New Orleans, Louisiana, November 2 to 5, 1992.
Penzias A, Lee G, Seifer D, Shamma F, DeCherney A, Reindollar R, Jones E. Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist-induced suppression is associated with impaired implantation**Presented at the 48th Annual Meeting of The American Fertility Society, New Orleans, Louisiana, November 2 to 5, 1992. Fertility And Sterility 1994, 61: 558-560. PMID: 8137986, DOI: 10.1016/s0015-0282(16)56595-9.Peer-Reviewed Original ResearchMeSH KeywordsEmbryo ImplantationEmbryo TransferEstradiolFemaleFollicle Stimulating HormoneHumansLeuprolideLuteinizing HormoneMenotropinsNafarelinOvaryPituitary GlandTime FactorsTreatment OutcomeConceptsAmerican Fertility SocietyBioactive LHDelayed suppressionImpairs implantationOvarian suppressionPituitary suppressionCycle outcomePrognostic markerE2 responseFertility SocietyE2 productionAberrant riseGnRHFurther studiesPrevious reportsRapid suppressionImplantationSuppressionAnnual MeetingLH