2022
Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review
Esencan E, Beroukhim G, Seifer D. Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review. Reproductive Biology And Endocrinology 2022, 20: 156. PMID: 36397149, PMCID: PMC9670479, DOI: 10.1186/s12958-022-01033-x.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor-1Vascular endothelial growth factorAge-related changesAntimullerian hormoneFertility outcomesIndividual studiesGrowth factor-1Endothelial growth factorObstetrical outcomesVitamin DOocyte quantityOvarian agingFollicular depletionFollicular fluidIntraovarian regulatorsRodent studiesHealthy oocytesNarrative reviewReproductive agingPotential modifiersCumulus cellsGrowth factorFactor 1Mitochondrial functionOutcomes
2018
Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality
Luke B, Brown MB, Wantman E, Seifer DB, Sparks AT, Lin PC, Doody KJ, Van Voorhis BJ, Spector LG. Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality. Journal Of Assisted Reproduction And Genetics 2018, 36: 121-138. PMID: 30328574, PMCID: PMC6338589, DOI: 10.1007/s10815-018-1333-z.Peer-Reviewed Original ResearchConceptsMaternal fertility statusRisk of prematurityIVF groupIVF pregnanciesDonor oocytesPlacental complicationsGreater riskInfant deathThawed embryosResultsThe study populationConfidence intervalsFertilization pregnanciesIVF infantsNICU admissionGestational diabetesInfant morbidityOdds ratioInfertility treatmentDeath certificatesLive birthsStudy populationPregnancyInfant's birthPrematurityOocyte source
2016
Society for Assisted Reproductive Technology and assisted reproductive technology in the United States: a 2016 update
Toner JP, Coddington CC, Doody K, Van Voorhis B, Seifer DB, Ball GD, Luke B, Wantman E. Society for Assisted Reproductive Technology and assisted reproductive technology in the United States: a 2016 update. Fertility And Sterility 2016, 106: 541-546. PMID: 27301796, DOI: 10.1016/j.fertnstert.2016.05.026.Peer-Reviewed Original Research
2015
Prognostic indicators of assisted reproduction technology outcomes of cycles with ultralow serum antimüllerian hormone: a multivariate analysis of over 5,000 autologous cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013
Seifer DB, Tal O, Wantman E, Edul P, Baker VL. Prognostic indicators of assisted reproduction technology outcomes of cycles with ultralow serum antimüllerian hormone: a multivariate analysis of over 5,000 autologous cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013. Fertility And Sterility 2015, 105: 385-393.e3. PMID: 26515380, DOI: 10.1016/j.fertnstert.2015.10.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersCryopreservationDatabases, FactualEmbryo TransferFemaleFertilityFertilization in VitroHumansInfertilityLinear ModelsLive BirthLogistic ModelsMiddle AgedMultivariate AnalysisOocyte RetrievalPatient SelectionPregnancyPregnancy RatePregnancy, MultipleReproductive Techniques, AssistedRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeYoung AdultConceptsLive birth rateAntimüllerian hormoneCancellation rateAMH levelsAssisted Reproductive Technology Clinic Outcome Reporting System databaseAssisted reproduction technology (ART) outcomesEmbryo cryopreservation ratesSerum antimüllerian hormoneTotal cancellation rateMultiple birth ratesReporting System databaseCycle startAutologous cyclesClinical pregnancyCycle cancellationPrognostic factorsAMH valuesFresh cyclesCycle outcomePrognostic indicatorAMH concentrationsRetrospective analysisMAIN OUTCOMEEmbryo transferMultivariate analysis
2014
Putting ‘family’ back in family planning
Seifer DB, Minkoff H, Merhi Z. Putting ‘family’ back in family planning. Human Reproduction 2014, 30: 16-19. PMID: 25406182, DOI: 10.1093/humrep/deu304.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsFamily Planning ServicesFemaleFertilityHumansInfertilityMaleMaternal Age
2012
High frequency of discordance between antimüllerian hormone and follicle-stimulating hormone levels in serum from estradiol-confirmed days 2 to 4 of the menstrual cycle from 5,354 women in U.S. fertility centers
Leader B, Hegde A, Baca Q, Stone K, Lannon B, Seifer DB, Broekmans F, Baker VL. High frequency of discordance between antimüllerian hormone and follicle-stimulating hormone levels in serum from estradiol-confirmed days 2 to 4 of the menstrual cycle from 5,354 women in U.S. fertility centers. Fertility And Sterility 2012, 98: 1037-1042. PMID: 22771028, DOI: 10.1016/j.fertnstert.2012.06.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAnti-Mullerian HormoneChemistry, ClinicalEstradiolFemaleFertilityFollicle Stimulating Hormone, HumanHumansMenstrual CycleMiddle AgedOocytesOvulation InductionPredictive Value of TestsPrognosisReference StandardsReproductive MedicineRetrospective StudiesUnited StatesYoung AdultConceptsYears of ageFSH valuesSerum AMHAntimüllerian hormoneAMH valuesFertility centerCut pointsDay 2Clinical discordanceMenstrual cycle day 2Follicle-stimulating hormone levelsCycle day 2Reference laboratoryFollicle-stimulating hormoneLarger patient populationSingle reference laboratoryFrequency of discordanceAge-dependent fashionClinical cut pointsSame serum samplesOvarian stimulationPatient populationAMH testingMenstrual cycleHormone levels