2014
Impact of CD4+ Lymphocytes and HIV Infection on Anti‐Müllerian Hormone Levels in a Large Cohort of HIV‐infected and HIV‐uninfected Women
Scherzer R, Bacchetti P, Messerlian G, Goderre J, Maki PM, Seifer DB, Anastos K, Karim R, Greenblatt RM. Impact of CD4+ Lymphocytes and HIV Infection on Anti‐Müllerian Hormone Levels in a Large Cohort of HIV‐infected and HIV‐uninfected Women. American Journal Of Reproductive Immunology 2014, 73: 273-284. PMID: 25339186, PMCID: PMC4323676, DOI: 10.1111/aji.12332.Peer-Reviewed Original ResearchConceptsAnti-Müllerian hormone levelsUninfected womenHigh AMHHIV infectionCD4 countLymphocyte countHormone levelsCurrent CD4 countImpact of CD4Total lymphocyte countCD4 T cellsHormonal contraceptive useOvarian granulosa cell functionsGranulosa cell functionPast weight lossHIV viraemiaNadir CD4Undetectable viraemiaUninfected participantsAMH levelsLow AMHOvarian functionDetectable viraemiaT cellsLarge cohort
2010
Age-specific serum anti-Müllerian hormone values for 17,120 women presenting to fertility centers within the United States
Seifer DB, Baker VL, Leader B. Age-specific serum anti-Müllerian hormone values for 17,120 women presenting to fertility centers within the United States. Fertility And Sterility 2010, 95: 747-750. PMID: 21074758, DOI: 10.1016/j.fertnstert.2010.10.011.Peer-Reviewed Original ResearchConceptsAnti-Müllerian hormone valuesAMH valuesHormone valuesAge 35Mean AMH valueSerum AMH valuesAverage yearly decreaseYears of ageU.S. fertility clinicsSpecific medianAMH levelsClinical reference laboratoryRetrospective studyFertility centerReproductive ageMAIN OUTCOMEAge 40Rate of declineFertility clinicsReference laboratoryWomenAgeReproductive optionsYearly decreaseSD values
2008
Variations in serum müllerian inhibiting substance between white, black, and Hispanic women
Seifer DB, Golub ET, Lambert-Messerlian G, Benning L, Anastos K, Watts DH, Cohen MH, Karim R, Young MA, Minkoff H, Greenblatt RM. Variations in serum müllerian inhibiting substance between white, black, and Hispanic women. Fertility And Sterility 2008, 92: 1674-1678. PMID: 18930217, PMCID: PMC3037722, DOI: 10.1016/j.fertnstert.2008.08.110.Peer-Reviewed Original ResearchConceptsBody mass indexHispanic womenHIV statusMass indexMulticenter prospective cohort studyWomen's Interagency HIV StudySerum MIS levelsProspective cohort studyTime pointsCohort studyDifferent time pointsMIS levelsAge-related declineHIV StudyDifferent time coursesMAIN OUTCOMESubstance levelsSerum MISWhite womenSerum samplesDifferent racial groupsWomenIndependent effectsLongitudinal studySmoking
2007
Biologic markers of ovarian reserve and reproductive aging: application in a cohort study of HIV infection in women
Seifer DB, Golub ET, Lambert-Messerlian G, Springer G, Holman S, Moxley M, Cejtin H, Nathwani N, Anastos K, Minkoff H, Greenblatt RM. Biologic markers of ovarian reserve and reproductive aging: application in a cohort study of HIV infection in women. Fertility And Sterility 2007, 88: 1645-1652. PMID: 17418155, PMCID: PMC2682326, DOI: 10.1016/j.fertnstert.2007.01.122.Peer-Reviewed Original ResearchConceptsWomen's Interagency HIV StudyEarly follicular phaseOvarian reserveInhibin BHIV infectionMIS levelsFollicular phaseHIV StudyLower inhibin B levelsReproductive agingSerum samplesHIV infection influencesInhibin B levelsMulticenter prospective studyCross-sectional studyMenstrual cycle phaseCycle phaseUninfected womenCohort studyFSH levelsMenstrual bleedingNegative womenHIV serostatusSerum markersProspective study
2002
Mitochondrial deletions in luteinized granulosa cells as a function of age in women undergoing in vitro fertilization
Seifer DB, DeJesus V, Hubbard K. Mitochondrial deletions in luteinized granulosa cells as a function of age in women undergoing in vitro fertilization. Fertility And Sterility 2002, 78: 1046-1048. PMID: 12413991, DOI: 10.1016/s0015-0282(02)04214-0.Peer-Reviewed Original ResearchConceptsGranulosa cellsAdvanced reproductive ageLuteinized granulosa cellsMitochondrial DNA deletionsGonadotropin stimulationReproductive ageMAIN OUTCOMEFollicular aspirationFertility clinicsFunction of ageYoung womenWomenIVFAgeDNA deletionsCellsMitochondrial deletionsYearsNormal mitochondriaNormal mtDNAPatientsDeletionClinicSubstantial decrease
1998
Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes
Whitacre K, Seifer D, Friedman C, Coskun S, Kennard E, Kim M, Alak B. Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes. Fertility And Sterility 1998, 70: 1015-1021. PMID: 9848288, DOI: 10.1016/s0015-0282(98)00339-2.Peer-Reviewed Original ResearchConceptsGerminal vesicle breakdownOvarian sourceNuclear maturationPatient ageGynecologic surgeryFollicular phaseLuteal phaseImmature human oocytesFinal meiotic maturationMenstrual cycle phaseYears of agePercentage of oocytesCycle phaseMetaphase II stageIVF programMenstrual cyclePatient criteriaMAIN OUTCOMEVitro maturationPatientsHuman oocytesOocyte maturationMII stageOocyte's abilityVesicle breakdownOocyte loss and the perimenopause.
Bopp BL, Seifer DB. Oocyte loss and the perimenopause. Clinical Obstetrics & Gynecology 1998, 41: 898-911. PMID: 9917945, DOI: 10.1097/00003081-199812000-00016.Peer-Reviewed Original ResearchThe detection of diminished ovarian reserve in infertile women
Sharara F, Scott R, Seifer D. The detection of diminished ovarian reserve in infertile women. American Journal Of Obstetrics And Gynecology 1998, 179: 804-812. PMID: 9757994, DOI: 10.1016/s0002-9378(98)70087-0.Peer-Reviewed Original ResearchConceptsOvarian reserveOwn gametesDiminished ovarian reserveFetal cardiac activityLower chanceReproductive technologiesInfertility populationInfertile womenProvocative testsPregnancy lossPregnancy rateInvasive therapyHigh incidenceExpensive treatmentWomenCardiac activityLate 30sEarly 40sMultiple testingDaily challengesPregnancyUltrasonographyInfertilityTherapyClinicians
1997
Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction
Friedman C, Danforth D, Herbosa-Encarnacion C, Arbogast L, Alak B, Seifer D. Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction. Fertility And Sterility 1997, 68: 607-612. PMID: 9341598, DOI: 10.1016/s0015-0282(97)00278-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgingCobaltCohort StudiesCorpus LuteumEndothelial Growth FactorsFemaleFollicular FluidGranulosa CellsHumansHypoxiaLymphokinesMaternal AgeMiddle AgedOsmolar ConcentrationOvulation InductionPregnancyPregnancy, High-RiskRetrospective StudiesTime FactorsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsAdvanced reproductive ageVascular endothelial growth factor/vascular permeability factorVascular permeability factorReproductive ageFollicular fluidFactor concentrationsPermeability factorFollicular fluid vascular endothelial growth factor concentrationsGranulosa cellsVascular endothelial growth factor concentrationsYoung womenRetrospective cohort studyReproductive-age womenUniversity Teaching HospitalPg/mLGrowth factor concentrationsCohort studyIVF-ETOvulation inductionHCG administrationAge womenCobalt chlorideTeaching hospitalMAIN OUTCOMEFollicular aspiration
1994
Dehydroepiandrosterone sulfate and anovulation increase serum inhibin and affect follicular function during administration of gonadotropins
Haning RV, Hua JJ, Hackett RJ, Wheeler CA, Frishman GN, Seifer DB, Dahl CA, Burger HG. Dehydroepiandrosterone sulfate and anovulation increase serum inhibin and affect follicular function during administration of gonadotropins. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 145-149. PMID: 8288697, DOI: 10.1210/jcem.78.1.8288697.Peer-Reviewed Original ResearchConceptsNumber of oocytesAnovulatory subjectsSerum inhibinAnovulatory ovariesSerum concentrationsNormal subjectsSerum DS concentrationSerum inhibin concentrationsAdministration of gonadotropinSecretion of inhibinResidual serum samplesDuration of treatmentAnovulatory patientsGonadotropin therapyInhibin concentrationsInhibin secretionPatient ageFertilization cyclesGonadotropin treatmentLH dosesFollicular functionHCG treatmentInhibinAverage durationSerum samples
1993
Proliferative index of human luteinized granulosa cells varies as a function of ovarian reserve
Seifer D, Charland C, Berlinsky D, Penzias A, Haning R, Naftolin F, Barker B. Proliferative index of human luteinized granulosa cells varies as a function of ovarian reserve. American Journal Of Obstetrics And Gynecology 1993, 169: 1531-1535. PMID: 8267057, DOI: 10.1016/0002-9378(93)90430-q.Peer-Reviewed Original ResearchConceptsSerum follicle-stimulating hormone levelsFollicle-stimulating hormone levelsFollicle-stimulating hormoneLuteinized granulosa cellsIU/L.Ovarian reserveHormone levelsProliferative indexGranulosa cellsHormone groupChronologic agePreovulatory folliclesDay 3 follicle-stimulating hormone levelsHigh follicle-stimulating hormoneLower follicle-stimulating hormoneSerum follicle-stimulating hormoneFlow cytometryHuman luteinized granulosa cellsGreater proliferative indexSame chronologic ageWoman's ovarian reserveOvulation induction protocolsProspective cohort studyAdvanced reproductive ageIU/L
1992
Flow cytometric analysis of deoxyribonucleic acid in human granulosa cells as a function of chronological age and ovulation induction regimen
Seifer DB, Honig J, Penzias AS, Lavy G, Nadkarni PM, Jones EE, DeCherney AH, Flynn SD. Flow cytometric analysis of deoxyribonucleic acid in human granulosa cells as a function of chronological age and ovulation induction regimen. The Journal Of Clinical Endocrinology & Metabolism 1992, 75: 636-640. PMID: 1639962, DOI: 10.1210/jcem.75.2.1639962.Peer-Reviewed Original ResearchConceptsHuman menopausal gonadotropinOvulation induction regimenGreater proliferative indexInduction regimenLeuprolide acetateProliferative indexGranulosa cellsGroup IGroup IIGroup IIIAmpules of hMGFunction of ageFlow cytometryDay of hCGProspective cohort studyGroup of patientsHuman granulosa cellsChronological ageMenopausal gonadotropinCohort studyOvulation inductionSerum FSHSignificant independent influenceOutcome measuresWomen's age
1990
Parameters of hypothalamic aging
Seifer D, Jones E. Parameters of hypothalamic aging. American Journal Of Obstetrics And Gynecology 1990, 163: 1715. PMID: 2240128, DOI: 10.1016/0002-9378(90)90658-t.Peer-Reviewed Original Research