A Combined Cytogenetic and Molecular Approach for Diagnosing Delayed Puberty
Hon Fong Louie Mark, Bayleran J, Seifer D, Meyers-Seifer C. A Combined Cytogenetic and Molecular Approach for Diagnosing Delayed Puberty. Clinical Pediatrics 1996, 35: 62-66. PMID: 8775477, DOI: 10.1177/000992289603500202.Peer-Reviewed Original ResearchConceptsLaparoscopic bilateral gonadectomyRisk of neoplasiaPeripheral blood leukocytesCell linesBilateral gonadectomyPolymerase chain reactionIntact short armsBlood leukocytesDelayed pubertyConventional cytogenetic studiesSubpopulation of cellsShort statureY chromosome materialChromosomal analysisChain reactionPubertyPhenotypic femalesCytogenetic studiesPresent reportCombined CytogeneticSitu hybridizationMolecular analysisUnequivocal evidenceCells