Neurotrophin-4/5 and Neurotrophin-3 Are Present within the Human Ovarian Follicle but Appear to Have Different Paracrine/Autocrine Functions
Seifer DB, Feng B, Shelden RM, Chen S, Dreyfus CF. Neurotrophin-4/5 and Neurotrophin-3 Are Present within the Human Ovarian Follicle but Appear to Have Different Paracrine/Autocrine Functions. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 4569-4571. PMID: 12364436, DOI: 10.1210/jc.2002-020499.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorNeurotrophin-3Human ovarian folliclesNT-4/5Follicular fluidOvarian folliclesNeurotrophin-4/5Paracrine/autocrine functionsTrk C receptorOocyte maturationSoluble polypeptide growth factorsFollicles of womenFollicular fluid samplesHuman follicular fluid samplesHuman follicular fluidPolar body extrusionMouse immature oocytesMammalian nervous systemMouse oocytesBDNF receptorTrk BNeurotrophic factorPolypeptide growth factorsFirst polar body extrusionNeurotrophin ligandsBrain-Derived Neurotrophic Factor: A Novel Human Ovarian Follicular Protein
Seifer DB, Feng B, Shelden RM, Chen S, Dreyfus CF. Brain-Derived Neurotrophic Factor: A Novel Human Ovarian Follicular Protein. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 655-659. PMID: 11836300, DOI: 10.1210/jcem.87.2.8213.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorOocyte maturationSecretion of BDNFSource of BDNFNervous systemRelease of BDNFSoluble polypeptide growth factorsHuman ovarian folliclesHuman follicular fluidCumulus granulosa cellsMammalian nervous systemFollicular proteinsBDNF receptorOocyte retrievalBDNF proteinTrk BNeurotrophic factorPolypeptide growth factorsHuman ovaryMural granulosaFollicular fluidMouse oocyte maturationOvarian folliclesGranulosa cellsEndocrine tissues