2022
Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome
Lynn A, Solomon N, Zamani M, Rowe E, Seifer D, Vash-Margita A. Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 134-139. PMID: 36403727, DOI: 10.1016/j.jpag.2022.11.005.Peer-Reviewed Original ResearchConceptsPCOS groupInsulin resistanceMenstrual patternAdolescent femalesControl groupRetrospective case-control studyLarge-scale prospective studiesAcute pelvic painEndometrial stripe thicknessTransabdominal pelvic ultrasoundTertiary children's hospitalPolycystic ovarian syndromeBody mass indexCase-control studyInstitutional review boardAdolescent PCOSEndometrial thicknessPelvic painOvarian syndromePCOS diagnosisPelvic ultrasoundUnique pathophysiologyEndocrinology clinicChildren's HospitalMass indexA Bedside Test to Detect the Presence of Embryonic or Fetal Tissue in Vaginal Blood
Volovsky M, Ayala M, Narayanamoorthy S, Chiware T, Kotlyar A, Taylor H, Seifer D, Mor A. A Bedside Test to Detect the Presence of Embryonic or Fetal Tissue in Vaginal Blood. Obstetrics And Gynecology 2022, 140: 983-988. PMID: 36357961, DOI: 10.1097/aog.0000000000004975.Peer-Reviewed Original ResearchConceptsVaginal bloodEctopic pregnancyPositive control groupAlpha-fetoproteinControl groupFetal tissuesNegative control groupComplete miscarriageIGFBP-1Bedside testStudy groupInsulin-like growth factor-binding protein-1Growth factor-binding protein-1First-trimester bleedingProspective cohort studyRapid bedside testIntrauterine pregnancyVaginal bleedingCohort studyNonpregnant individualsReproductive-aged individualsPregnant individualsRapid test stripPregnancyMiscarriage
2014
Vitamin D Normalizes Abnormally Elevated Serum Antimüllerian Hormone Levels Usually Noted in Women With Polycystic Ovary Syndrome
Irani M, Seifer D, Minkoff H, Merhi Z. Vitamin D Normalizes Abnormally Elevated Serum Antimüllerian Hormone Levels Usually Noted in Women With Polycystic Ovary Syndrome. Obstetrics And Gynecology 2014, 123: 189s. DOI: 10.1097/01.aog.0000447216.52829.8e.Peer-Reviewed Original ResearchPolycystic ovary syndromeVitamin D3 supplementationAntimüllerian hormone concentrationsVitamin D deficiencyD3 supplementationAntimüllerian hormoneD deficiencyHormone concentrationsControl groupVitamin D3 therapyHormone serum levelsNon-PCOS womenSerum of womenAntimüllerian hormone levelsWeeks of supplementationOvulatory dysfunctionD3 therapyDeficient womenOvary syndromeSerum levelsVitamin DMetabolic disturbancesHormone levelsVitamin D3Follicular health
2000
Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values?
Trout S, Seifer D. Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values? Fertility And Sterility 2000, 74: 335-337. PMID: 10927054, DOI: 10.1016/s0015-0282(00)00625-7.Peer-Reviewed Original ResearchConceptsDay 3 serum FSHRecurrent pregnancy lossUnexplained recurrent pregnancy lossCauses of RPLSerum FSHPregnancy lossControl groupOvarian reserveDay 3 FSHUnexplained habitual abortionDiminished ovarian reservePresence of infertilityHistory of infertilityRetrospective comparative analysisUnexplained groupRPL groupHabitual abortionMean ageMAIN OUTCOMEFSHGreater incidenceTest groupWomenPotential roleInfertility
1994
Increasing Hypothalamic Arcuate Nucleus Glial Peroxidase Activity in Aging Female Rats Is Reduced by an Antiestrogen and a Gonadotropin-Releasing Hormone Agonist
Seifer D, Roa-Peña L, Keefe D, Zhang H, Goodman S, Jones E, Naftolin F. Increasing Hypothalamic Arcuate Nucleus Glial Peroxidase Activity in Aging Female Rats Is Reduced by an Antiestrogen and a Gonadotropin-Releasing Hormone Agonist. Menopause The Journal Of The North American Menopause Society 1994, 1: 83-90. DOI: 10.1097/00042192-199400120-00005.Peer-Reviewed Original ResearchMonths of ageFemale ratsGoserelin acetate depotPosterior periventricular areasComputerized image analyzerAge-related increaseDiaminobenzidine tetrahydrochloridePeriventricular areaArcuate nucleusGoserelin acetateEndogenous estrogensHypothalamic sectionsControl groupSuper agonistReproductive agingMonthsRatsPeroxidase activityDAB reactionAgeGroupImplantsAnimalsImage analyzerSerial sectioning
1993
Gonadotropin-releasing hormone agonist-induced differences in granulosa cell cycle kinetics are associated with alterations in follicular fluid müllerian-inhibiting substance and androgen content
Seifer DB, MacLaughlin DT, Penzias AS, Behrman HR, Asmundson L, Donahoe PK, Haning RV, Flynn SD. Gonadotropin-releasing hormone agonist-induced differences in granulosa cell cycle kinetics are associated with alterations in follicular fluid müllerian-inhibiting substance and androgen content. The Journal Of Clinical Endocrinology & Metabolism 1993, 76: 711-714. PMID: 8445031, DOI: 10.1210/jcem.76.3.8445031.Peer-Reviewed Original ResearchConceptsHuman menopausal gonadotropinCell cycle kineticsProliferative indexGranulosa cellsFollicular fluidControl groupCycle kineticsGnRH analogue leuprolideOvulation induction regimensFollicular fluid contentMüllerian-inhibiting substanceHuman granulosa cellsLuteinized granulosa cellsCI (3.2-3.6) PInduction regimensMenopausal gonadotropinOocyte retrievalAndrogen contentGnRHSpecific growth factorsFlow cytometryGrowth factorFolliclesFluid contentOne-way analysis