1997
Identification of V(D)J recombination coding end intermediates in normal thymocytes 11Edited by K. Yamamoto
Livák F, Schatz D. Identification of V(D)J recombination coding end intermediates in normal thymocytes 11Edited by K. Yamamoto. Journal Of Molecular Biology 1997, 267: 1-9. PMID: 9096202, DOI: 10.1006/jmbi.1996.0834.Peer-Reviewed Original ResearchConceptsRecombination signal sequencesNormal lymphoid precursorsSignal endsJ alpha genesPre-B cell linesGene rearrangement processDouble-strand breaksNormal murine thymocytesSignal sequenceLymphoid precursorsK. YamamotoAlpha geneFirst direct demonstrationHairpin structureLow abundanceStrand breaksGene segmentsCell linesAntigen receptorMurine thymocytesRecombinationDirect demonstrationVivoJoint formationNormal thymocytes
1993
Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.
Petrie HT, Livak F, Schatz DG, Strasser A, Crispe IN, Shortman K. Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes. Journal Of Experimental Medicine 1993, 178: 615-622. PMID: 8393478, PMCID: PMC2191132, DOI: 10.1084/jem.178.2.615.Peer-Reviewed Original ResearchConceptsAlpha/beta heterodimerMultiple rearrangementsTCR alpha/beta heterodimerBeta heterodimerBeta chainT-cell receptor alpha-chain geneChain geneTCR alpha geneTCR alphaSurface expressionReceptor alpha-chain geneTransgenic TCR beta chainTCR alpha locusAlpha chain geneT cell receptor alphaAlpha gene rearrangementsMajority of TCREndogenous TCR alpha chainsHeavy chain genePositive selectionSomatic rearrangementsAllelic exclusionAlpha geneAlpha locusTCR alpha chain