Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro.
Widnell K, Russell D, Nestler E. Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 10947-10951. PMID: 7971989, PMCID: PMC45143, DOI: 10.1073/pnas.91.23.10947.Peer-Reviewed Original ResearchConceptsLocus coeruleusCREB expressionCREB immunoreactivityCell linesChronic morphine administrationLocus coeruleus neuronsCRE-binding activityResponse element-binding proteinCAMP pathwayCREB mRNA levelsCAMP response element-binding proteinMorphine administrationChronic morphineCoeruleus neuronsBrain regionsCRE bindingOpiate addictionElement-binding proteinPC12 pheochromocytoma cellsCAMP response elementMRNA levelsPheochromocytoma cellsCoeruleusImmunoreactivityCREB mRNA