1996
Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens.
Widnell K, Self D, Lane S, Russell D, Vaidya V, Miserendino M, Rubin C, Duman R, Nestler E. Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens. Journal Of Pharmacology And Experimental Therapeutics 1996, 276: 306-15. PMID: 8558448.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCyclic AMP Response Element-Binding ProteinCyclic AMP-Dependent Protein KinasesDown-RegulationGTP-Binding ProteinsMaleMolecular Sequence DataMorphineNucleus AccumbensOligonucleotides, AntisenseProtein Sorting SignalsRatsRats, Sprague-DawleyRNA, MessengerSensitivity and SpecificitySignal TransductionConceptsCAMP response element-binding proteinEffects of morphineNucleus accumbensBrain regionsCREB levelsChronic opiate administrationCAMP pathwayTranscription factor cAMP response element-binding proteinResponse element-binding proteinProperties of opiatesMorphine administrationAnti-sense oligonucleotide strategyMorphine actionOpiate administrationSustained decreaseLong-term effectsElement-binding proteinNervous systemCREB expressionOpiate addictionCREB immunoreactivityDetectable toxicityVivo evidenceMorphineAccumbens
1995
Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system
Berhow M, Russell D, Terwilliger R, Beitner-Johnson D, Self D, Lindsay R, Nestler E. Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system. Neuroscience 1995, 68: 969-979. PMID: 8545003, DOI: 10.1016/0306-4522(95)00207-y.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdenylyl CyclasesAnimalsAutoradiographyCocaineCyclic AMP-Dependent Protein KinasesDopamineGlial Fibrillary Acidic ProteinInjectionsLimbic SystemMaleMorphineNarcotic AntagonistsNarcoticsNerve Growth FactorsNeurofilament ProteinsNucleus AccumbensRatsRats, Sprague-DawleyTyrosine 3-MonooxygenaseVentral Tegmental AreaConceptsVentral tegmental areaIntra-ventral tegmental area infusionBrain-derived neurotrophic factorGlial fibrillary acidic proteinTyrosine hydroxylase levelsNeurotrophic factorFactor infusionFibrillary acidic proteinTegmental areaMorphine treatmentNerve growth factorAdenylyl cyclase activityNucleus accumbensTyrosine hydroxylaseChronic morphineNeurotrophin-4Cocaine treatmentCocaine exposureHydroxylase levelsGlial fibrillary acidic protein levelsAcidic proteinCyclase activityGrowth factorChronic morphine treatmentChronic cocaine treatment