2003
Phospholipase Cγ in Distinct Regions of the Ventral Tegmental Area Differentially Modulates Mood-Related Behaviors
Bolaños C, Perrotti L, Edwards S, Eisch A, Barrot M, Olson V, Russell D, Neve R, Nestler E. Phospholipase Cγ in Distinct Regions of the Ventral Tegmental Area Differentially Modulates Mood-Related Behaviors. Journal Of Neuroscience 2003, 23: 7569-7576. PMID: 12930795, PMCID: PMC6740761, DOI: 10.1523/jneurosci.23-20-07569.2003.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDrugs of abuseAnxiety-like behaviorOverexpression of PLCgamma1Nociceptive stimuliTegmental areaAversive stimuliCaudal ventral tegmental areaDrug-induced elevationMood-related behaviorsMorphine place preferenceMorphine-paired compartmentDistinct topographical regionsViral-mediated gene transferEmotional stimuliNeurotrophic factorNeural substratesNatural rewardsPlace preference
2000
Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse
Messer C, Eisch A, Carlezon W, Whisler K, Shen L, Wolf D, Westphal H, Collins F, Russell D, Nestler E. Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse. Neuron 2000, 26: 247-257. PMID: 10798408, PMCID: PMC4451194, DOI: 10.1016/s0896-6273(00)81154-x.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDrugs of abuseAnti-GDNF antibodyIntra-VTA infusionDopaminergic brain regionsSubsequent drug exposureChronic morphineDrug exposureTegmental areaChronic cocaineCocaine exposureRewarding effectsGDNF geneGDNF pathwayBrain regionsGDNFBehavioral sensitivityCocaineDrugsMorphineInfusionPresent studyExposureNull mutationAbuse
1999
Regulation of Phospholipase Cγ in the Mesolimbic Dopamine System by Chronic Morphine Administration
Wolf D, Numan S, Nestler E, Russell D. Regulation of Phospholipase Cγ in the Mesolimbic Dopamine System by Chronic Morphine Administration. Journal Of Neurochemistry 1999, 73: 1520-1528. PMID: 10501197, PMCID: PMC1993239, DOI: 10.1046/j.1471-4159.1999.0731520.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDopamineDrug ImplantsGene Expression RegulationGene Expression Regulation, EnzymologicInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsIsoenzymesLimbic SystemMaleMorphineNeuronsOrgan SpecificityPhosphatidylinositol 3-KinasesPhospholipase C gammaPhosphoproteinsRatsRats, Sprague-DawleyRNA, MessengerTegmentum MesencephaliTranscription, GeneticType C PhospholipasesConceptsRas-ERK pathwayInsulin receptor substrateVentral tegmental areaNeurotrophic signaling pathwaysMesolimbic dopamine systemPhospholipase Cgamma1Receptor substratePhospholipase CγSignaling pathwaysPathway proteinsDopamine systemProteinPLCgamma1MRNA levelsChronic morphine exposureChronic morphine administrationRegulationPathwayAppreciable levelsMRNA expressionMorphine exposureMorphine administrationDopaminergic neuronsNeurotrophic factorTegmental area
1995
Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system
Berhow M, Russell D, Terwilliger R, Beitner-Johnson D, Self D, Lindsay R, Nestler E. Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system. Neuroscience 1995, 68: 969-979. PMID: 8545003, DOI: 10.1016/0306-4522(95)00207-y.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdenylyl CyclasesAnimalsAutoradiographyCocaineCyclic AMP-Dependent Protein KinasesDopamineGlial Fibrillary Acidic ProteinInjectionsLimbic SystemMaleMorphineNarcotic AntagonistsNarcoticsNerve Growth FactorsNeurofilament ProteinsNucleus AccumbensRatsRats, Sprague-DawleyTyrosine 3-MonooxygenaseVentral Tegmental AreaConceptsVentral tegmental areaIntra-ventral tegmental area infusionBrain-derived neurotrophic factorGlial fibrillary acidic proteinTyrosine hydroxylase levelsNeurotrophic factorFactor infusionFibrillary acidic proteinTegmental areaMorphine treatmentNerve growth factorAdenylyl cyclase activityNucleus accumbensTyrosine hydroxylaseChronic morphineNeurotrophin-4Cocaine treatmentCocaine exposureHydroxylase levelsGlial fibrillary acidic protein levelsAcidic proteinCyclase activityGrowth factorChronic morphine treatmentChronic cocaine treatment