Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse
Messer C, Eisch A, Carlezon W, Whisler K, Shen L, Wolf D, Westphal H, Collins F, Russell D, Nestler E. Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse. Neuron 2000, 26: 247-257. PMID: 10798408, PMCID: PMC4451194, DOI: 10.1016/s0896-6273(00)81154-x.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDrugs of abuseAnti-GDNF antibodyIntra-VTA infusionDopaminergic brain regionsSubsequent drug exposureChronic morphineDrug exposureTegmental areaChronic cocaineCocaine exposureRewarding effectsGDNF geneGDNF pathwayBrain regionsGDNFBehavioral sensitivityCocaineDrugsMorphineInfusionPresent studyExposureNull mutationAbuse