2021
In vivo evidence of differential frontal cortex metabolic abnormalities in progressive and relapsing‐remitting multiple sclerosis
Swanberg KM, Prinsen H, DeStefano K, Bailey M, Kurada AV, Pitt D, Fulbright RK, Juchem C. In vivo evidence of differential frontal cortex metabolic abnormalities in progressive and relapsing‐remitting multiple sclerosis. NMR In Biomedicine 2021, 34: e4590. PMID: 34318959, DOI: 10.1002/nbm.4590.Peer-Reviewed Original ResearchConceptsProgressive multiple sclerosisRelapsing-remitting multiple sclerosisMultiple sclerosis patientsMultiple sclerosisDisease durationSclerosis patientsRelapsing-remitting multiple sclerosis patientsSignificant negative correlationAvailable disease-modifying therapiesFrontal cortex metabolismH-MRS protocolDisease-modifying therapiesHealthy control adultsN-acetyl aspartateCross-sectional analysisCortex metabolismMetabolic abnormalitiesΓ-aminobutyric acidMetabolites glutamateFrontal cortexSclerosisNegative correlationControl adultsGABAProton MRS
2013
Iron Is a Sensitive Biomarker for Inflammation in Multiple Sclerosis Lesions
Mehta V, Pei W, Yang G, Li S, Swamy E, Boster A, Schmalbrock P, Pitt D. Iron Is a Sensitive Biomarker for Inflammation in Multiple Sclerosis Lesions. PLOS ONE 2013, 8: e57573. PMID: 23516409, PMCID: PMC3597727, DOI: 10.1371/journal.pone.0057573.Peer-Reviewed Original ResearchConceptsMyelin-laden macrophagesMS patientsSecondary progressive MS patientsProgressive MS patientsSecondary progressive MSMultiple sclerosis patientsMacrophages/microgliaWhite matter lesionsHuman macrophage culturesIron-containing macrophagesMultiple sclerosis lesionsImportant clinical informationHuman cultured macrophagesActive relapsingDemyelinating lesionsDisease-relevant processesProgressive MSDemyelinated lesionsSclerosis patientsMultiple sclerosisMatter lesionsM1 polarizationImmunohistochemical examinationMyelin phagocytosisProinflammatory polarization