2021
Vagus nerve stimulation induces widespread cortical and behavioral activation
Collins L, Boddington L, Steffan P, McCormick D. Vagus nerve stimulation induces widespread cortical and behavioral activation. Current Biology 2021, 31: 2088-2098.e3. PMID: 33740425, DOI: 10.1016/j.cub.2021.02.049.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsArousalCalciumCerebral CortexFemaleMaleMiceNeuronal PlasticityNorepinephrineVagus Nerve StimulationConceptsVagus nerve stimulationCalcium imagingNeuromodulatory systemsVagus nerve transectionAuditory cortical regionsWidefield calcium imagingArousal stateDose-dependent activationNerve transectionVNS effectsNerve stimulationExcitatory activityCortical axonsModulatory pathwaysExcitatory neuronsLight anesthesiaNeurological conditionsTherapeutic mechanismMouse modelStimulation inducesArousal state changesCortical activityCortical stateMotor activityCortical regions
1996
Abolition of Spindle Oscillations by Serotonin and Norepinephrine in the Ferret Lateral Geniculate and Perigeniculate Nuclei In Vitro
Lee K, McCormick D. Abolition of Spindle Oscillations by Serotonin and Norepinephrine in the Ferret Lateral Geniculate and Perigeniculate Nuclei In Vitro. Neuron 1996, 17: 309-321. PMID: 8780654, DOI: 10.1016/s0896-6273(00)80162-2.Peer-Reviewed Original ResearchConceptsSpindle wave generationThalamocortical neuronsSpindle wavesPerigeniculate nucleusLocal applicationDorsal lateral geniculate nucleusHyperpolarization-activated cation current IhModulation of IhLateral geniculate nucleusBeta-adrenergic agonistsAdenylyl cyclase activatorGABAergic cellsLateral geniculateChannel blockersGeniculate nucleusNorepinephrineLamina A1Current IhNeuronsSpindle oscillationsCyclase activatorSerotoninIHBlockersAgonists
1993
Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD
Wang Z, McCormick D. Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD. Journal Of Neuroscience 1993, 13: 2199-2216. PMID: 8386756, PMCID: PMC6576582, DOI: 10.1523/jneurosci.13-05-02199.1993.Peer-Reviewed Original ResearchConceptsIntracellular recordingsMetabotropic receptorsPyramidal cellsLayer V pyramidal cellsGlutamate metabotropic receptor agonistLayer V cellsMetabotropic receptor agonistApplication of norepinephrineAlpha-agonist phenylephrineBeta-antagonist propranololSingle spike activityMuscarinic antagonist scopolamineBeta-agonist isoprenalinePrimary visual cortexAction potential generationSingle-spike modeACh effectsMuscarinic subtypesNE responseInterburst frequencyMuscarinic agonistsReceptor agonistBath applicationPostsynaptic responsesAntagonist scopolamine
1992
Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus
McCormick D. Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus. Journal Of Neuroscience 1992, 12: 278-289. PMID: 1309574, PMCID: PMC6575696, DOI: 10.1523/jneurosci.12-01-00278.1992.Peer-Reviewed Original ResearchConceptsInward current responseSlow depolarizationIntracellular recordingsDorsal lateral geniculate neuronsCat LGNdDorsal lateral geniculate nucleusPertussis toxin-insensitive G proteinToxin-insensitive G proteinGABAB agonist baclofenSingle spike activityActivation of muscarinicLateral geniculate neuronsSubpopulation of neuronsApplication of AChApplication of noradrenalineLateral geniculate nucleusRhythmic oscillationsPossible involvementSingle-spike firingThalamocortical relay cellsG proteinsHigh-frequency burstsLGNd neuronsPostsynaptic actionsAgonist baclofen
1991
Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal
McCormick D, Williamson A. Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal. Journal Of Neuroscience 1991, 11: 3188-3199. PMID: 1658246, PMCID: PMC6575455, DOI: 10.1523/jneurosci.11-10-03188.1991.Peer-Reviewed Original ResearchConceptsSlow depolarizing responseApplication of histamineSingle spike activityDepolarizing responseSlow depolarizationIntracellular recordingsPotassium currentGuinea pigsLateral geniculate relay neuronsCat LGNdHyperpolarization-activated cation current IhEnhancement of IhGeniculate relay neuronsH2 antagonist cimetidineThalamic neuronal activityRhythmic burst dischargesH1-receptor antagonistAction of histamineH1 antagonist pyrilamineVoltage-clamp recordingsPossible cellular mechanismsApparent membrane conductanceHistaminergic controlHistaminergic projectionsMembrane conductance
1990
IONIC MECHANISMS OF MODULATORY BRAIN STEM INFLUENCES IN THE THALAMUS
Pape H, McCormick D. IONIC MECHANISMS OF MODULATORY BRAIN STEM INFLUENCES IN THE THALAMUS. Journal Of Basic And Clinical Physiology And Pharmacology 1990, 1: 107-118. PMID: 1964799, DOI: 10.1515/jbcpp.1990.1.1-4.107.Peer-Reviewed Original Research
1989
Convergence and divergence of neurotransmitter action in human cerebral cortex.
McCormick D, Williamson A. Convergence and divergence of neurotransmitter action in human cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 8098-8102. PMID: 2573061, PMCID: PMC298222, DOI: 10.1073/pnas.86.20.8098.Peer-Reviewed Original ResearchConceptsHuman cerebral cortexPostsynaptic actionsCerebral cortexPutative neurotransmittersMuscarinic receptor agonistApplication of acetylcholineCortical pyramidal cellsGamma-aminobutyric acidDistinct potassium currentsSpecific anatomical connectionsSpike frequency adaptationPostsynaptic receptorsReceptor agonistPyramidal cellsNeurotransmitter systemsM-currentNeuronal firingNeurotransmitter actionPotassium currentCortical activityAnatomical connectionsSerotoninNeurotransmittersNorepinephrineAcetylcholineNoradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current
Pape H, McCormick D. Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current. Nature 1989, 340: 715-718. PMID: 2475782, DOI: 10.1038/340715a0.Peer-Reviewed Original ResearchConceptsThalamic neuronsRhythmic burstsAction potentialsHyperpolarization-activated cation currentSingle spike activityGenerate action potentialsSlow-wave sleepSingle-spike firingState of excitabilityAction potential generationSerotonergic inputNeurons displaySynaptic processingSpike activityCation currentThalamic burstsSpike firingNoradrenalineSerotoninCellular mechanismsNeuronsRhythmic oscillationsNovel actionBehavioral statesCyclic AMP
1988
Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro
McCormick D, Prince D. Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro. Journal Of Neurophysiology 1988, 59: 978-996. PMID: 3367206, DOI: 10.1152/jn.1988.59.3.978.Peer-Reviewed Original ResearchConceptsSlow depolarizationElectrophysiological actionsPT neuronsGuinea pigsSlow membrane timeSpike frequency accommodationApplication of norepinephrineSingle spike activityMedial geniculate nucleusExtracellular potassium concentrationCat thalamic neuronsLarge afterhyperpolarizationSlow afterdepolarizationSlow afterhyperpolarizationAnteroventral nucleusCerebral cortexFrequency accommodationThalamic neuronsThalamocortical rhythmsThalamic nucleiGeniculate nucleusIntracellular recordingsNoradrenergic modulationSynaptic transmissionThalamic slices
1982
Locus coeruleus lesions and resistance to extinction of a classically conditioned response: Involvement of the neocortex and hippocampus
McCormick D, Thompson R. Locus coeruleus lesions and resistance to extinction of a classically conditioned response: Involvement of the neocortex and hippocampus. Brain Research 1982, 245: 239-249. PMID: 7127072, DOI: 10.1016/0006-8993(82)90806-x.Peer-Reviewed Original ResearchConceptsDepletion of norepinephrineExtinction deficitNon-lesioned controlsBilateral electrolytic lesionsLocus coeruleus lesionsHippocampal norepinephrineLocus coeruleusNE depletionDopamine levelsHippocampal samplesElectrolytic lesionsDay 3Control groupNorepinephrineBrain regionsHypothalamus/Significant differencesThird groupUnpaired trainingLesionsNM responseUnpaired extinctionConditioned responseSignificant depletionAnimals