2020
Neuromodulation of Brain State and Behavior
McCormick D, Nestvogel D, He B. Neuromodulation of Brain State and Behavior. Annual Review Of Neuroscience 2020, 43: 1-25. PMID: 32250724, DOI: 10.1146/annurev-neuro-100219-105424.Peer-Reviewed Original Research
2015
Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output
Zagha E, Ge X, McCormick DA. Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output. Neuron 2015, 88: 565-577. PMID: 26593093, PMCID: PMC4660255, DOI: 10.1016/j.neuron.2015.09.044.Peer-Reviewed Original ResearchConceptsPopulations of neuronsAnticipation of movementMotor cortexCortical neuronsCortical circuitsIntracellular techniquesUnit recordingsNeural ensemblesMotor outputNeuronsSensory stimuliNeural activityMotor representationsSensory detection taskMotor commandsFuture studiesTask-related neural dynamicsCortexMiceCellular activitiesWaking State: Rapid Variations Modulate Neural and Behavioral Responses
McGinley MJ, Vinck M, Reimer J, Batista-Brito R, Zagha E, Cadwell CR, Tolias AS, Cardin JA, McCormick DA. Waking State: Rapid Variations Modulate Neural and Behavioral Responses. Neuron 2015, 87: 1143-1161. PMID: 26402600, PMCID: PMC4718218, DOI: 10.1016/j.neuron.2015.09.012.Peer-Reviewed Original Research
2013
Motor Cortex Feedback Influences Sensory Processing by Modulating Network State
Zagha E, Casale AE, Sachdev RN, McGinley MJ, McCormick DA. Motor Cortex Feedback Influences Sensory Processing by Modulating Network State. Neuron 2013, 79: 567-578. PMID: 23850595, PMCID: PMC3742632, DOI: 10.1016/j.neuron.2013.06.008.Peer-Reviewed Original Research
2010
Endogenous Electric Fields May Guide Neocortical Network Activity
Fröhlich F, McCormick DA. Endogenous Electric Fields May Guide Neocortical Network Activity. Neuron 2010, 67: 129-143. PMID: 20624597, PMCID: PMC3139922, DOI: 10.1016/j.neuron.2010.06.005.Peer-Reviewed Original ResearchSynaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation
Haider B, Krause MR, Duque A, Yu Y, Touryan J, Mazer JA, McCormick DA. Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation. Neuron 2010, 65: 107-121. PMID: 20152117, PMCID: PMC3110675, DOI: 10.1016/j.neuron.2009.12.005.Peer-Reviewed Original ResearchConceptsClassical receptive fieldCat primary visual cortexReceptive field stimulationVisual cortical activityPrimary visual cortexReceptive fieldsNonclassical receptive fieldPyramidal neuronsField stimulationSynaptic potentialsEntire visual fieldMembrane potential responsesNeuronal subtypesCortical activityVisual cortexRecurrent excitationVisual fieldVisual responsesIncreased activityStimulationInhibitory barragesNeuron spikingNetwork mechanismsVisual system studiesNatural vision
2009
Spatial and Temporal Features of Synaptic to Discharge Receptive Field Transformation in Cat Area 17
Nowak L, Sanchez-Vives M, McCormick D. Spatial and Temporal Features of Synaptic to Discharge Receptive Field Transformation in Cat Area 17. Journal Of Neurophysiology 2009, 103: 677-697. PMID: 19906874, PMCID: PMC2822677, DOI: 10.1152/jn.90946.2008.Peer-Reviewed Original ResearchRapid Neocortical Dynamics: Cellular and Network Mechanisms
Haider B, McCormick DA. Rapid Neocortical Dynamics: Cellular and Network Mechanisms. Neuron 2009, 62: 171-189. PMID: 19409263, PMCID: PMC3132648, DOI: 10.1016/j.neuron.2009.04.008.Peer-Reviewed Original Research
2007
State Changes Rapidly Modulate Cortical Neuronal Responsiveness
Hasenstaub A, Sachdev RN, McCormick DA. State Changes Rapidly Modulate Cortical Neuronal Responsiveness. Journal Of Neuroscience 2007, 27: 9607-9622. PMID: 17804621, PMCID: PMC6672966, DOI: 10.1523/jneurosci.2184-07.2007.Peer-Reviewed Original ResearchConceptsNeuronal responsivenessWhisker stimulationWhisker stimuliCircuit activityCortical neuronal responsivenessLocal circuit activityNetwork activityAction potential responsesLocal network activityRodent somatosensory cortexPostsynaptic potentialsSomatosensory cortexCortical neuronsIntracellular injectionWhisker deflectionCortical stateWhisker movementsPotential responsivenessAbility of stimuliSensory stimuliInhibitory mechanismStimulationResponsivenessSpontaneous alterationUp statesEnhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo
Haider B, Duque A, Hasenstaub A, Yu Y, McCormick D. Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo. Journal Of Neurophysiology 2007, 97: 4186-4202. PMID: 17409168, DOI: 10.1152/jn.01114.2006.Peer-Reviewed Original ResearchConceptsPostsynaptic potentialsVisual responsivenessSpontaneous depolarizationsNetwork activityNeocortical network activityInhibitory synaptic potentialsPrimary visual cortexLocal network activityAction potential generationContrast response functionsCortical neuronsSynaptic potentialsSynaptic transmissionSpontaneous activityMembrane potential depolarizationKetamine-xylazineExtracellular recordingsVisual cortexAction potentialsLocal circuitsIntegrative propertiesSensory responsesPotential depolarizationSlow oscillationsPotential generation
2006
Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings
Shu Y, Duque A, Yu Y, Haider B, McCormick D. Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings. Journal Of Neurophysiology 2006, 97: 746-760. PMID: 17093120, DOI: 10.1152/jn.00922.2006.Peer-Reviewed Original ResearchConceptsCortical pyramidal cellsAction potential initiationAxon initial segmentPyramidal cellsAction potentialsSynaptic activityLayer 5 pyramidal neuronsSimultaneous whole-cell recordingsWhole-cell recordingsNeocortical pyramidal cellsRecurrent network activityAction potential generationInitial segmentIntradendritic injectionPyramidal neuronsApical dendritesEpileptiform activityCortical neuronsEpileptiform dischargesIntracortical axonsEpileptic seizuresSynaptic bombardmentCell recordingsDistal axonsSynaptic barragesNeocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition
Haider B, Duque A, Hasenstaub A, McCormick D. Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition. Journal Of Neuroscience 2006, 26: 4535-4545. PMID: 16641233, PMCID: PMC6674060, DOI: 10.1523/jneurosci.5297-05.2006.Peer-Reviewed Original ResearchConceptsCerebral cortexNeocortical network activityReversal potentialUp statesPersistent network activityNetwork activityDepolarized reversal potentialSpontaneous network activityField potential recordingsLocal cortical circuitsLocal field potential recordingsNeuronal responsivenessCortical functionRecurrent excitatoryCortical circuitsSynaptic currentsPotential recordingsRecurrent excitationExcitatory conductancePrefrontal cortexInhibitory connectionsCortexStable network statesSlow oscillationsInhibition
2005
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick D. Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks. Neuron 2005, 47: 423-435. PMID: 16055065, DOI: 10.1016/j.neuron.2005.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCerebral CortexCortical SynchronizationExcitatory Postsynaptic PotentialsFerretsIn Vitro TechniquesInterneuronsMaleMembrane PotentialsNerve NetNeural InhibitionNeuronsOscillometryPyramidal CellsReaction TimeRefractory Period, ElectrophysiologicalSynapsesSynaptic TransmissionConceptsInhibitory postsynaptic potentialsHigh-frequency activityPostsynaptic potentialsPyramidal cellsCortical pyramidal cellsAction potential propertiesRecurrent network activityAction potential generationActive cortical networkInhibitory interneuronsCortical functionIntracellular injectionNearby neuronsStrong barragesInhibitory networksCortical networksField potentialsSynaptic conductancesIPSPsInhibitory potentialPotential generationNetwork activitySpike timingMore synchronyVivo
2003
Barrages of Synaptic Activity Control the Gain and Sensitivity of Cortical Neurons
Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick D. Barrages of Synaptic Activity Control the Gain and Sensitivity of Cortical Neurons. Journal Of Neuroscience 2003, 23: 10388-10401. PMID: 14614098, PMCID: PMC6741011, DOI: 10.1523/jneurosci.23-32-10388.2003.Peer-Reviewed Original ResearchConceptsSynaptic activityCortical neuronsLayer 5 pyramidal cellsVisual cortical slicesInhibitory synaptic activityOngoing synaptic activityEnhancement of responsivenessAction potential activationBackground synaptic activityExcitatory postsynaptic conductancesSpike-timing precisionInput-output curvesProbability of responseNeuronal responsivenessCortical slicesPyramidal cellsIntracellular recordingsSynaptic inputsSpontaneous periodSynaptic bombardmentSynaptic barragesPostsynaptic conductanceMembrane depolarizationNeuronal processingCortical cellsTurning on and off recurrent balanced cortical activity
Shu Y, Hasenstaub A, McCormick D. Turning on and off recurrent balanced cortical activity. Nature 2003, 423: 288-293. PMID: 12748642, DOI: 10.1038/nature01616.Peer-Reviewed Original ResearchConceptsCerebral cortexLocal cortical circuitsCortical neuronsNeuronal excitabilitySynaptic inputsCortical circuitsSpontaneous activityCortical activitySynaptic connectionsRecurrent excitationCortical organizationCortexNeuronsLocal recurrent connectionsRecurrent activitySelf-sustained activityHypothesized roleInhibitionVast majorityActivityExcitabilityExcitatory
2001
Brain calculus: neural integration and persistent activity
McCormick D. Brain calculus: neural integration and persistent activity. Nature Neuroscience 2001, 4: 113-114. PMID: 11175863, DOI: 10.1038/83917.Peer-Reviewed Original Research
2000
Cellular and network mechanisms of rhythmic recurrent activity in neocortex
Sanchez-Vives M, McCormick D. Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nature Neuroscience 2000, 3: 1027-1034. PMID: 11017176, DOI: 10.1038/79848.Peer-Reviewed Original ResearchConceptsSlow-wave sleepLocal cortical circuitsSlow oscillationsFerret neocortexCerebral cortexExtracellular ionic compositionPyramidal neuronsCortical circuitsCortical rhythmsSlow rhythmRecurrent excitationLayer 5NeocortexInhibitory networksExcitatory interactionsBathing mediumExcitatory stateSleepRecurrent activityRhythmCortexNeuronsNetwork mechanismsCorticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks
Blumenfeld H, McCormick D. Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks. Journal Of Neuroscience 2000, 20: 5153-5162. PMID: 10864972, PMCID: PMC6772273, DOI: 10.1523/jneurosci.20-13-05153.2000.Peer-Reviewed Original ResearchConceptsParoxysmal oscillationsThalamic burstsReceptor antagonist CGP 35348Corticothalamic tractsSpindle wavesAntagonist CGP 35348Receptor antagonist picrotoxinSlow-wave sleepHz oscillationsHigh-frequency burstsNormal action potentialPerigeniculate neuronsCGP 35348Antagonist picrotoxinSlow IPSPCorticothalamic inputsFast IPSPsThalamocortical neuronsCortical influencesAbsence seizuresBurst firingCortical neuronsCortical firingThalamocortical networkCorticothalamic networks
1999
Spontaneous activity: signal or noise?
McCormick D. Spontaneous activity: signal or noise? Science 1999, 285: 541-3. PMID: 10447487, DOI: 10.1126/science.285.5427.541.Peer-Reviewed Original Research
1998
H-Current Properties of a Neuronal and Network Pacemaker
Lüthi A, McCormick D. H-Current Properties of a Neuronal and Network Pacemaker. Neuron 1998, 21: 9-12. PMID: 9697847, DOI: 10.1016/s0896-6273(00)80509-7.Peer-Reviewed Original Research