1999
Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling
Cremona O, Di Paolo G, Wenk M, Lüthi A, Kim W, Takei K, Daniell L, Nemoto Y, Shears S, Flavell R, McCormick D, De Camilli P. Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling. Cell 1999, 99: 179-188. PMID: 10535736, DOI: 10.1016/s0092-8674(00)81649-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell-Free SystemCerebral CortexCoated Pits, Cell-MembraneEndocytosisEnzyme InhibitorsExonsHippocampusIn Vitro TechniquesMembrane PotentialsMiceMice, KnockoutMicroscopy, ElectronNerve EndingsNerve Tissue ProteinsNeuronsPhosphatidylinositolsPhosphoric Monoester HydrolasesSynaptic VesiclesModulation of a pacemaker current through Ca2+-induced stimulation of cAMP production
Lüthi A, McCormick D. Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production. Nature Neuroscience 1999, 2: 634-641. PMID: 10404196, DOI: 10.1038/10189.Peer-Reviewed Original ResearchConceptsHyperpolarization-activated cation currentIh activationThalamocortical rhythmsThalamocortical activityCation currentNeuronal propertiesPacemaker currentCAMP productionPersistent activationProlonged changesProlonged activationBrief increaseDependent modulationSlow recurrenceActivationSubsequent productionCa2RecurrenceModulation
1984
Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses
Clark G, McCormick D, Lavond D, Thompson R. Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses. Brain Research 1984, 291: 125-136. PMID: 6697177, DOI: 10.1016/0006-8993(84)90658-9.Peer-Reviewed Original ResearchConceptsCerebellar nucleiNeuronal responsesUnilateral electrolytic lesionsHippocampal neuronal responsesEffects of lesionsIpsilateral sideContralateral sideControl animalsElectrolytic lesionsHippocampal responsesDeep nucleiLesionsLearning deficitsLeft sideRight sideNeural activityTrials of trainingComplete abolition
1982
Locus coeruleus lesions and resistance to extinction of a classically conditioned response: Involvement of the neocortex and hippocampus
McCormick D, Thompson R. Locus coeruleus lesions and resistance to extinction of a classically conditioned response: Involvement of the neocortex and hippocampus. Brain Research 1982, 245: 239-249. PMID: 7127072, DOI: 10.1016/0006-8993(82)90806-x.Peer-Reviewed Original ResearchConceptsDepletion of norepinephrineExtinction deficitNon-lesioned controlsBilateral electrolytic lesionsLocus coeruleus lesionsHippocampal norepinephrineLocus coeruleusNE depletionDopamine levelsHippocampal samplesElectrolytic lesionsDay 3Control groupNorepinephrineBrain regionsHypothalamus/Significant differencesThird groupUnpaired trainingLesionsNM responseUnpaired extinctionConditioned responseSignificant depletionAnimals