2006
Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings
Shu Y, Duque A, Yu Y, Haider B, McCormick D. Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings. Journal Of Neurophysiology 2006, 97: 746-760. PMID: 17093120, DOI: 10.1152/jn.00922.2006.Peer-Reviewed Original ResearchConceptsCortical pyramidal cellsAction potential initiationAxon initial segmentPyramidal cellsAction potentialsSynaptic activityLayer 5 pyramidal neuronsSimultaneous whole-cell recordingsWhole-cell recordingsNeocortical pyramidal cellsRecurrent network activityAction potential generationInitial segmentIntradendritic injectionPyramidal neuronsApical dendritesEpileptiform activityCortical neuronsEpileptiform dischargesIntracortical axonsEpileptic seizuresSynaptic bombardmentCell recordingsDistal axonsSynaptic barrages
2005
Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus
Broberger C, McCormick D. Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus. Journal Of Neuroscience 2005, 25: 1664-1673. PMID: 15716402, PMCID: PMC6725920, DOI: 10.1523/jneurosci.3198-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineCalcium SignalingEpilepsyFemaleFerretsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesIn Vitro TechniquesInterneuronsIon TransportMaleMethacholine ChlorideMuscarinic AgonistsPatch-Clamp TechniquesPotassiumPotassium ChannelsReceptors, GABA-AThalamusThyrotropin-Releasing HormoneWakefulnessConceptsThyrotropin-releasing hormoneThalamocortical cellsApplication of TRHNeuropeptide thyrotropin-releasing hormoneRapid eye movement (REM) sleepRhythmic burst firingAnti-epileptic effectsEye movement sleepApplication of bicucullineLateral geniculate nucleusSlow-wave sleepThalamocortical network activityAction potential generationSingle-spike modeNonspecific currentsPerigeniculate neuronsExcitatory effectsGABAergic neuronsMovement sleepPGN neuronsBath applicationBurst firingGeniculate nucleusIntracellular recordingsDirect depolarization
2001
ON THE CELLULAR AND NETWORK BASES OF EPILEPTIC SEIZURES
McCormick D, Contreras D. ON THE CELLULAR AND NETWORK BASES OF EPILEPTIC SEIZURES. Annual Review Of Physiology 2001, 63: 815-846. PMID: 11181977, DOI: 10.1146/annurev.physiol.63.1.815.Peer-Reviewed Original ResearchConceptsCerebral cortexEpileptic seizuresSynchronized burstsRhythmic burst dischargesSpike-wave activityIntrinsic membrane propertiesForm of seizuresPeriod of hyperpolarizationLoss of balanceRecurrent excitatory connectionsEpileptic syndromesSeizure dischargesPyramidal neuronsTonic depolarizationEpileptiform activitySeizure generationBurst dischargesInhibitory neuronsInhibitory influenceInterictal spikesNormal brain rhythmsSynaptic plasticityAction potentialsSeizuresMammalian forebrain
2000
Cellular and network mechanisms of rhythmic recurrent activity in neocortex
Sanchez-Vives M, McCormick D. Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nature Neuroscience 2000, 3: 1027-1034. PMID: 11017176, DOI: 10.1038/79848.Peer-Reviewed Original ResearchConceptsSlow-wave sleepLocal cortical circuitsSlow oscillationsFerret neocortexCerebral cortexExtracellular ionic compositionPyramidal neuronsCortical circuitsCortical rhythmsSlow rhythmRecurrent excitationLayer 5NeocortexInhibitory networksExcitatory interactionsBathing mediumExcitatory stateSleepRecurrent activityRhythmCortexNeuronsNetwork mechanisms