2009
Circuit-based Localization of Ferret Prefrontal Cortex
Duque A, McCormick DA. Circuit-based Localization of Ferret Prefrontal Cortex. Cerebral Cortex 2009, 20: 1020-1036. PMID: 19737780, PMCID: PMC2852501, DOI: 10.1093/cercor/bhp164.Peer-Reviewed Original Research
2008
Cortical Action Potential Backpropagation Explains Spike Threshold Variability and Rapid-Onset Kinetics
Yu Y, Shu Y, McCormick DA. Cortical Action Potential Backpropagation Explains Spike Threshold Variability and Rapid-Onset Kinetics. Journal Of Neuroscience 2008, 28: 7260-7272. PMID: 18632930, PMCID: PMC2664555, DOI: 10.1523/jneurosci.1613-08.2008.Peer-Reviewed Original ResearchConceptsAxon initial segmentAction potentialsAction potential backpropagationAction potential outputAction potential responsesThreshold variabilityInitial segmentCortical neuronsSynaptic activitySynaptic inputsSomatic recordingsCortical ensemblesSensorimotor integrationRate variabilityAction potential eventsSpike initiationAmplitude-time courseTime courseHigh rateTrial variabilityNeurons
2006
Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings
Shu Y, Duque A, Yu Y, Haider B, McCormick D. Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings. Journal Of Neurophysiology 2006, 97: 746-760. PMID: 17093120, DOI: 10.1152/jn.00922.2006.Peer-Reviewed Original ResearchConceptsCortical pyramidal cellsAction potential initiationAxon initial segmentPyramidal cellsAction potentialsSynaptic activityLayer 5 pyramidal neuronsSimultaneous whole-cell recordingsWhole-cell recordingsNeocortical pyramidal cellsRecurrent network activityAction potential generationInitial segmentIntradendritic injectionPyramidal neuronsApical dendritesEpileptiform activityCortical neuronsEpileptiform dischargesIntracortical axonsEpileptic seizuresSynaptic bombardmentCell recordingsDistal axonsSynaptic barrages
2003
Barrages of Synaptic Activity Control the Gain and Sensitivity of Cortical Neurons
Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick D. Barrages of Synaptic Activity Control the Gain and Sensitivity of Cortical Neurons. Journal Of Neuroscience 2003, 23: 10388-10401. PMID: 14614098, PMCID: PMC6741011, DOI: 10.1523/jneurosci.23-32-10388.2003.Peer-Reviewed Original ResearchConceptsSynaptic activityCortical neuronsLayer 5 pyramidal cellsVisual cortical slicesInhibitory synaptic activityOngoing synaptic activityEnhancement of responsivenessAction potential activationBackground synaptic activityExcitatory postsynaptic conductancesSpike-timing precisionInput-output curvesProbability of responseNeuronal responsivenessCortical slicesPyramidal cellsIntracellular recordingsSynaptic inputsSpontaneous periodSynaptic bombardmentSynaptic barragesPostsynaptic conductanceMembrane depolarizationNeuronal processingCortical cells