2011
Active Action Potential Propagation But Not Initiation in Thalamic Interneuron Dendrites
Casale A, McCormick D. Active Action Potential Propagation But Not Initiation in Thalamic Interneuron Dendrites. Journal Of Neuroscience 2011, 31: 18289-18302. PMID: 22171033, PMCID: PMC3269759, DOI: 10.1523/jneurosci.4417-11.2011.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusLateral geniculate nucleusSomatic current injectionAction potentialsDendritic arborsGeniculate nucleusSynaptic stimulationThalamic interneuronsMouse dorsal lateral geniculate nucleusDendritic neurotransmitter releaseEntire dendritic arborSingle action potentialAxon initial segmentVoltage-gated sodiumProximal dendritesDendritic appendagesInhibitory neurotransmitterExcitatory inputsInhibitory interneuronsVoltage-sensitive dyeSynaptic inputsThalamocortical cellsCalcium transientsCalcium imagingNeurotransmitter release
2010
P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons
Yu Y, Maureira C, Liu X, McCormick D. P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons. Journal Of Neuroscience 2010, 30: 11858-11869. PMID: 20810905, PMCID: PMC2947942, DOI: 10.1523/jneurosci.2651-10.2010.Peer-Reviewed Original ResearchConceptsAxon initial segmentNeuronal excitabilityPyramidal cellsCalcium concentrationPresynaptic terminalsWhole-cell patch-clamp recordingsPrefrontal cortical pyramidal cellsOmega-agatoxin IVAOmega-conotoxin GVIACortical pyramidal cellsPatch-clamp recordingsBaseline calcium concentrationAction potential repolarizationAction potential generationNeocortical axonsVoltage-activated ion channelsCalcium currentCortical axonsSynaptic terminalsCalcium levelsCalcium channelsSynaptic boutonsSuprathreshold depolarizationElectrophysiological propertiesSubthreshold depolarization
2007
Selective control of cortical axonal spikes by a slowly inactivating K+ current
Shu Y, Yu Y, Yang J, McCormick D. Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 11453-11458. PMID: 17581873, PMCID: PMC2040919, DOI: 10.1073/pnas.0702041104.Peer-Reviewed Original ResearchConceptsSpike durationLayer 5 pyramidal cellsWhole-cell recordingsIntracortical processingPyramidal cellsIntracortical axonsLow dosesDistal axonsAxonal spikesRepetitive dischargesAxonsMembrane potential changesRemarkable differential expressionSomaDifferential expressionAlpha subunitIonic channelsSmall increaseKv1.2 alpha subunitsDurationNeuronsDoses
2006
Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings
Shu Y, Duque A, Yu Y, Haider B, McCormick D. Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings. Journal Of Neurophysiology 2006, 97: 746-760. PMID: 17093120, DOI: 10.1152/jn.00922.2006.Peer-Reviewed Original ResearchConceptsCortical pyramidal cellsAction potential initiationAxon initial segmentPyramidal cellsAction potentialsSynaptic activityLayer 5 pyramidal neuronsSimultaneous whole-cell recordingsWhole-cell recordingsNeocortical pyramidal cellsRecurrent network activityAction potential generationInitial segmentIntradendritic injectionPyramidal neuronsApical dendritesEpileptiform activityCortical neuronsEpileptiform dischargesIntracortical axonsEpileptic seizuresSynaptic bombardmentCell recordingsDistal axonsSynaptic barragesModulation of intracortical synaptic potentials by presynaptic somatic membrane potential
Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick D. Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 2006, 441: 761-765. PMID: 16625207, DOI: 10.1038/nature04720.Peer-Reviewed Original ResearchConceptsIntracortical synaptic potentialsSomatic membrane potentialCerebral cortexMembrane potentialPostsynaptic potentialsSynaptic potentialsSynaptic activityEpileptic seizuresAction potentialsSensory stimulationNeuronal communicationMembrane potential changesNeuronal signalsRecording pointsSole formPossible alternative mechanismSeizuresCortexAxonsNeurons
1997
Inhibitory Interactions between Perigeniculate GABAergic Neurons
Sanchez-Vives M, Bal T, McCormick D. Inhibitory Interactions between Perigeniculate GABAergic Neurons. Journal Of Neuroscience 1997, 17: 8894-8908. PMID: 9348356, PMCID: PMC6573073, DOI: 10.1523/jneurosci.17-22-08894.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAction PotentialsAnimalsAnticonvulsantsAxonsBaclofenBicucullineCalciumCerebral CortexExcitatory Postsynaptic PotentialsFemaleFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGlutamic AcidMaleMuscimolNeural InhibitionNeuronsOrganophosphorus CompoundsPicrotoxinReceptors, GABA-AReceptors, GABA-BReceptors, PresynapticTetrodotoxinThalamic NucleiConceptsPGN neuronsPerigeniculate nucleusGABAB receptorsGABAergic neuronsIntracellular recordingsDorsal lateral geniculate nucleusActivation of inhibitionSpecific agonist muscimolGABAA receptor blockadeLow-threshold Ca2Lateral geniculate nucleusAverage reversal potentialBarrages of EPSPsFunctional GABAAPerigeniculate neuronsReceptor blockadeSlow IPSPBicuculline methiodideTonic dischargeAxon collateralsThalamocortical neuronsAgonist muscimolSubset of cellsGABAA receptorsGeniculate nucleusPhysiological properties of inhibitory interneurons in cat striate cortex.
Azouz R, Gray C, Nowak L, McCormick D. Physiological properties of inhibitory interneurons in cat striate cortex. Cerebral Cortex 1997, 7: 534-545. PMID: 9276178, DOI: 10.1093/cercor/7.6.534.Peer-Reviewed Original ResearchConceptsBrief action potentialsReceptive field propertiesReceptive field typesSpike frequency adaptationSimple receptive fieldsAxonal arborizationIntracellular recordingsInhibitory interneuronsBasket cellsSpontaneous activityStriate cortexLayers IIAction potentialsFiring patternsResponsive cellsVisual stimulationFrequency adaptationDirection preferenceInterneuronsHigh rateReceptive fieldsCortexCatsCellsSpike trainsSynchronized Oscillations in the Inferior Olive Are Controlled by the Hyperpolarization-Activated Cation Current I h
Bal T, McCormick D. Synchronized Oscillations in the Inferior Olive Are Controlled by the Hyperpolarization-Activated Cation Current I h. Journal Of Neurophysiology 1997, 77: 3145-3156. PMID: 9212264, DOI: 10.1152/jn.1997.77.6.3145.Peer-Reviewed Original ResearchConceptsLow-threshold Ca2Inferior olive nucleusIO neuronsGuinea pigsHyperpolarization-activated cationic currentLocal applicationDependent action potentialsPresence of apaminMembrane potentialInferior olive neuronsIntracellular recordingsIntracellular injectionPacemaker potentialsRhythmic generationInferior oliveAfterhyperpolarizationAction potentialsCationic currentRemoval of inactivationExtracellular applicationNeuronsHyperpolarizationApaminCa2Pigs
1996
Are the Interlaminar Zones of the Ferret Dorsal Lateral Geniculate Nucleus Actually Part of the Perigeniculate Nucleus?
Sanchez-Vives M, Bal T, Kim U, von Krosigk M, McCormick D. Are the Interlaminar Zones of the Ferret Dorsal Lateral Geniculate Nucleus Actually Part of the Perigeniculate Nucleus? Journal Of Neuroscience 1996, 16: 5923-5941. PMID: 8815875, PMCID: PMC6579195, DOI: 10.1523/jneurosci.16-19-05923.1996.Peer-Reviewed Original ResearchConceptsInterlaminar zonesThalamocortical cellsDorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusFerret LGNdLow-threshold Ca2Calbindin-positive cellsLateral geniculate nucleusCalbindin stainingPerigeniculate neuronsPGN cellsContralateral eyeA-laminaeAxon collateralsC laminaePGN neuronsPerigeniculate nucleusGeniculate nucleusIntracellular injectionLamina AElectrophysiological propertiesLocal applicationProlonged depolarizationProlonged hyperpolarizationNeuronsIonic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices
Destexhe A, Bal T, McCormick D, Sejnowski T. Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. Journal Of Neurophysiology 1996, 76: 2049-2070. PMID: 8890314, DOI: 10.1152/jn.1996.76.3.2049.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBicucullineCalciumCalcium ChannelsElectrophysiologyFerretsGABA AntagonistsIn Vitro TechniquesIon ChannelsKineticsMembrane PotentialsModels, NeurologicalNeural Networks, ComputerPotassium ChannelsRecruitment, NeurophysiologicalRefractory Period, ElectrophysiologicalReticular FormationSynapsesThalamusUp-RegulationConceptsInhibitory postsynaptic potentialsExcitatory postsynaptic potentialsSlow inhibitory postsynaptic potentialFerret thalamic slicesActivity-dependent upregulationTC cellsRE cellsPostsynaptic potentialsThalamic slicesGABAergic inhibitory postsynaptic potentialsSpindle oscillationsCalcium-sensitive currentGABAB inhibitory postsynaptic potentialsLocal axonal arborizationsThalamic reticular neuronsGamma-aminobutyric acidRE neuronsGABAB receptorsIsoxazolepropionic acidRebound burstsReticular neuronsTC neuronsGABAA inhibitionAxonal arborizationBurst discharges