2007
Thalamic synchrony and dynamic regulation of global forebrain oscillations
Huguenard J, McCormick D. Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends In Neurosciences 2007, 30: 350-356. PMID: 17544519, DOI: 10.1016/j.tins.2007.05.007.Peer-Reviewed Original ResearchConceptsSpike-wave dischargesRelay neuronsReticular nucleusInhibitory thalamic reticular neuronsThalamic oscillatory activityGeneralized absence epilepsyThalamic reticular neuronsThalamocortical relay neuronsRegulation of excitabilityPost-inhibitory rebound mechanismAnnual INMED/TINS symposiumINMED/TINS special issue PhysiogenicThalamic synchronyReticular neuronsAbsence epilepsySynaptic connectivityThalamic circuitsThalamocortical networkSpindle generationThalamic networkPathological oscillationsOscillatory activitySpecific interventionsSleep spindlesGenetic alterations
2000
Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks
Blumenfeld H, McCormick D. Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks. Journal Of Neuroscience 2000, 20: 5153-5162. PMID: 10864972, PMCID: PMC6772273, DOI: 10.1523/jneurosci.20-13-05153.2000.Peer-Reviewed Original ResearchConceptsParoxysmal oscillationsThalamic burstsReceptor antagonist CGP 35348Corticothalamic tractsSpindle wavesAntagonist CGP 35348Receptor antagonist picrotoxinSlow-wave sleepHz oscillationsHigh-frequency burstsNormal action potentialPerigeniculate neuronsCGP 35348Antagonist picrotoxinSlow IPSPCorticothalamic inputsFast IPSPsThalamocortical neuronsCortical influencesAbsence seizuresBurst firingCortical neuronsCortical firingThalamocortical networkCorticothalamic networks
1999
Chapter 17 Thalamic and thalamocortical mechanisms underlying 3 Hz spike-and-wave discharges
Destexhe A, McCormick D, Sejnowski T. Chapter 17 Thalamic and thalamocortical mechanisms underlying 3 Hz spike-and-wave discharges. Progress In Brain Research 1999, 121: 289-307. PMID: 10551033, DOI: 10.1016/s0079-6123(08)63080-0.Peer-Reviewed Original Research
1998
Periodicity of Thalamic Synchronized Oscillations: the Role of Ca2+-Mediated Upregulation of Ih
Lüthi A, McCormick D. Periodicity of Thalamic Synchronized Oscillations: the Role of Ca2+-Mediated Upregulation of Ih. Neuron 1998, 20: 553-563. PMID: 9539128, DOI: 10.1016/s0896-6273(00)80994-0.Peer-Reviewed Original ResearchConceptsPersistent activationRefractory periodHyperpolarization-activated cation current IhNeural network oscillationsSynchronized network activityWave seizuresRole of Ca2Synchronized dischargesThalamocortical cellsThalamocortical networkElectrophysiological propertiesMediated UpregulationSpindle wavesCurrent IhConstituent neuronsNetwork oscillationsAbnormal patternsActivation curveTime courseNetwork activityUpregulationActivationCritical determinant
1997
Functional Dynamics of GABAergic Inhibition in the Thalamus
Kim U, Sanchez-Vives M, McCormick D. Functional Dynamics of GABAergic Inhibition in the Thalamus. Science 1997, 278: 130-134. PMID: 9311919, DOI: 10.1126/science.278.5335.130.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineDendritesFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGlutamic AcidIn Vitro TechniquesLysineNeuronsOrganophosphorus CompoundsPatch-Clamp TechniquesPresynaptic TerminalsReceptors, GABA-AReceptors, GABA-BSynaptic TransmissionThalamic NucleiConceptsInhibitory postsynaptic potentialsGABAergic inhibitionThalamic reticularThalamocortical networkLow-frequency tonic dischargeGABAergic inhibitory postsynaptic potentialsDorsal lateral geniculate nucleusPatterns of activityLateral geniculate nucleusSlow-wave sleepPerigeniculate neuronsTonic dischargeGABAB receptorsThalamocortical neuronsPerigeniculate cellsPostsynaptic potentialsGABAA receptorsGeniculate nucleusThalamocortical cellsNeuronsGeneration of activityReceptorsReticularDistinct patternsInhibition
1996
What Stops Synchronized Thalamocortical Oscillations?
Bal T, McCormick D. What Stops Synchronized Thalamocortical Oscillations? Neuron 1996, 17: 297-308. PMID: 8780653, DOI: 10.1016/s0896-6273(00)80161-0.Peer-Reviewed Original Research
1993
30 Cellular Basis and Neurotransmitter Control of Thalamic Oscillation and Sensory Transmission Address for Correspondence: Section of Neurobiology, Sterling Hall of Medicine Rm. C303, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
McCORMICK D, BAL T, VON KROSIGK M. 30 Cellular Basis and Neurotransmitter Control of Thalamic Oscillation and Sensory Transmission Address for Correspondence: Section of Neurobiology, Sterling Hall of Medicine Rm. C303, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. 1993, 357-373. DOI: 10.1016/b978-0-08-042274-9.50036-5.Peer-Reviewed Original ResearchThalamocortical networkModulatory transmitter systemsDifferent disease statesSensory transmissionCerebral cortexThalamic oscillationsYale University SchoolNeurotransmitter controlThalamocortical loopThalamocortical systemDisease statesSensory processingRhythmic oscillationsTransmitter systemsCellular basisMotor informationThalamusUniversity School