1993
A model for 8–10 Hz spindling in interconnected thalamic relay and reticularis neurons
Destexhe A, McCormick D, Sejnowski T. A model for 8–10 Hz spindling in interconnected thalamic relay and reticularis neurons. Biophysical Journal 1993, 65: 2473-2477. PMID: 8312485, PMCID: PMC1225988, DOI: 10.1016/s0006-3495(93)81297-9.Peer-Reviewed Original ResearchConceptsReticular cellsReticular thalamic cellsInhibitory postsynaptic potentialsIntrinsic oscillatory propertiesReticularis neuronsSpindle rhythmicityPostsynaptic potentialsInhibitory synapsesThalamic cellsThalamic relayThalamocortical cellsSilent periodSynaptic interactionsSpindle oscillationsRhythmic oscillationsCells30 Cellular Basis and Neurotransmitter Control of Thalamic Oscillation and Sensory Transmission Address for Correspondence: Section of Neurobiology, Sterling Hall of Medicine Rm. C303, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
McCORMICK D, BAL T, VON KROSIGK M. 30 Cellular Basis and Neurotransmitter Control of Thalamic Oscillation and Sensory Transmission Address for Correspondence: Section of Neurobiology, Sterling Hall of Medicine Rm. C303, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. 1993, 357-373. DOI: 10.1016/b978-0-08-042274-9.50036-5.Peer-Reviewed Original ResearchThalamocortical networkModulatory transmitter systemsDifferent disease statesSensory transmissionCerebral cortexThalamic oscillationsYale University SchoolNeurotransmitter controlThalamocortical loopThalamocortical systemDisease statesSensory processingRhythmic oscillationsTransmitter systemsCellular basisMotor informationThalamusUniversity School
1992
Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus
McCormick D. Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus. Journal Of Neuroscience 1992, 12: 278-289. PMID: 1309574, PMCID: PMC6575696, DOI: 10.1523/jneurosci.12-01-00278.1992.Peer-Reviewed Original ResearchConceptsInward current responseSlow depolarizationIntracellular recordingsDorsal lateral geniculate neuronsCat LGNdDorsal lateral geniculate nucleusPertussis toxin-insensitive G proteinToxin-insensitive G proteinGABAB agonist baclofenSingle spike activityActivation of muscarinicLateral geniculate neuronsSubpopulation of neuronsApplication of AChApplication of noradrenalineLateral geniculate nucleusRhythmic oscillationsPossible involvementSingle-spike firingThalamocortical relay cellsG proteinsHigh-frequency burstsLGNd neuronsPostsynaptic actionsAgonist baclofen
1989
Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current
Pape H, McCormick D. Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current. Nature 1989, 340: 715-718. PMID: 2475782, DOI: 10.1038/340715a0.Peer-Reviewed Original ResearchConceptsThalamic neuronsRhythmic burstsAction potentialsHyperpolarization-activated cation currentSingle spike activityGenerate action potentialsSlow-wave sleepSingle-spike firingState of excitabilityAction potential generationSerotonergic inputNeurons displaySynaptic processingSpike activityCation currentThalamic burstsSpike firingNoradrenalineSerotoninCellular mechanismsNeuronsRhythmic oscillationsNovel actionBehavioral statesCyclic AMPCholinergic and noradrenergic modulation of thalamocortical processing
McCormick D. Cholinergic and noradrenergic modulation of thalamocortical processing. Trends In Neurosciences 1989, 12: 215-221. PMID: 2473557, DOI: 10.1016/0166-2236(89)90125-2.Peer-Reviewed Original ResearchConceptsThalamocortical processingPeriods of drowsinessState of excitabilityModulatory neurotransmitter systemsNeuronal responsivenessNoradrenergic componentThalamocortical rhythmsCortical neuronsNeurotransmitter systemsNoradrenergic modulationSynaptic inputsNeuronal activityPotassium currentSynchronized sleepMarked increaseRhythmic oscillationsRhythmNorepinephrineAcetylcholineExcitabilitySleepNeuronsDrowsiness