Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.
McCormick D, von Krosigk M. Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 2774-2778. PMID: 1313567, PMCID: PMC48745, DOI: 10.1073/pnas.89.7.2774.Peer-Reviewed Original ResearchConceptsSlow-wave sleepCerebral cortexThalamic neuronsRelay neuronsWave sleepLateral geniculate relay neuronsProlonged excitatory postsynaptic potentialGeniculate relay neuronsLayer VI cellsExcitatory postsynaptic potentialsThalamic relay neuronsSensory informationSingle-spike modeBrainstem inputsPostsynaptic potentialsCorticothalamic fibersSlow depolarizationObligatory relayState-dependent mannerSensory transferThalamusMammalian thalamusPotassium conductanceProlonged enhancementNeurons