GABA as an inhibitory neurotransmitter in human cerebral cortex
McCormick D. GABA as an inhibitory neurotransmitter in human cerebral cortex. Journal Of Neurophysiology 1989, 62: 1018-1027. PMID: 2573696, DOI: 10.1152/jn.1989.62.5.1018.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsGamma-aminobutyric acidEarly inhibitory postsynaptic potentialHuman cerebral cortexExcitatory postsynaptic potentialsAverage reversal potentialCerebral cortexInhibitory neurotransmitterPostsynaptic potentialsLate inhibitory postsynaptic potentialsSlow inhibitory postsynaptic potentialGABAergic inhibitory postsynaptic potentialsInitial excitatory postsynaptic potentialsReversal potentialGABAB agonist baclofenGABAB antagonist phaclofenGABAA antagonist bicucullineGABAA agonist muscimolParoxysmal epileptiform activityMajor inhibitory neurotransmitterVitro. 2Antagonist phaclofenMembrane conductanceAgonist baclofenAntagonist bicucullineConvergence and divergence of neurotransmitter action in human cerebral cortex.
McCormick D, Williamson A. Convergence and divergence of neurotransmitter action in human cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 8098-8102. PMID: 2573061, PMCID: PMC298222, DOI: 10.1073/pnas.86.20.8098.Peer-Reviewed Original ResearchConceptsHuman cerebral cortexPostsynaptic actionsCerebral cortexPutative neurotransmittersMuscarinic receptor agonistApplication of acetylcholineCortical pyramidal cellsGamma-aminobutyric acidDistinct potassium currentsSpecific anatomical connectionsSpike frequency adaptationPostsynaptic receptorsReceptor agonistPyramidal cellsNeurotransmitter systemsM-currentNeuronal firingNeurotransmitter actionPotassium currentCortical activityAnatomical connectionsSerotoninNeurotransmittersNorepinephrineAcetylcholine