Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning
Martin K, Papadoyannis E, Schiavo J, Fadaei S, Issa H, Song S, Valencia S, Temiz N, McGinley M, McCormick D, Froemke R. Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning. Nature Neuroscience 2024, 27: 2152-2166. PMID: 39284963, DOI: 10.1038/s41593-024-01767-4.Peer-Reviewed Original ResearchVagus nerve stimulationCentral cholinergic systemNerve stimulationEfficacy of vagus nerve stimulationCholinergic systemVagus nerve stimulation electrodesExperience-dependent plasticityAuditory cortical responsesPeripheral nerve stimulationCholinergic modulationAuditory discrimination taskClinical conditionsTwo-photon imagingCortical responsesCentral mechanismsCholinergic axonsStimulationEnhance task performanceNeural activityOptogenetic experimentsDiscrimination taskDiscrimination abilityEnhances perceptual learningPerceptual learningTask performance