1992
Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus
McCormick D. Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus. Journal Of Neuroscience 1992, 12: 278-289. PMID: 1309574, PMCID: PMC6575696, DOI: 10.1523/jneurosci.12-01-00278.1992.Peer-Reviewed Original ResearchConceptsInward current responseSlow depolarizationIntracellular recordingsDorsal lateral geniculate neuronsCat LGNdDorsal lateral geniculate nucleusPertussis toxin-insensitive G proteinToxin-insensitive G proteinGABAB agonist baclofenSingle spike activityActivation of muscarinicLateral geniculate neuronsSubpopulation of neuronsApplication of AChApplication of noradrenalineLateral geniculate nucleusRhythmic oscillationsPossible involvementSingle-spike firingThalamocortical relay cellsG proteinsHigh-frequency burstsLGNd neuronsPostsynaptic actionsAgonist baclofen
1991
Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal
McCormick D, Williamson A. Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal. Journal Of Neuroscience 1991, 11: 3188-3199. PMID: 1658246, PMCID: PMC6575455, DOI: 10.1523/jneurosci.11-10-03188.1991.Peer-Reviewed Original ResearchConceptsSlow depolarizing responseApplication of histamineSingle spike activityDepolarizing responseSlow depolarizationIntracellular recordingsPotassium currentGuinea pigsLateral geniculate relay neuronsCat LGNdHyperpolarization-activated cation current IhEnhancement of IhGeniculate relay neuronsH2 antagonist cimetidineThalamic neuronal activityRhythmic burst dischargesH1-receptor antagonistAction of histamineH1 antagonist pyrilamineVoltage-clamp recordingsPossible cellular mechanismsApparent membrane conductanceHistaminergic controlHistaminergic projectionsMembrane conductance
1988
Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus
McCormick D, Pape H. Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus. Nature 1988, 334: 246-248. PMID: 3398922, DOI: 10.1038/334246a0.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusRelay cellsGeniculate nucleusDorsal lateral geniculate nucleusMuscarinic receptor-mediated increaseBrainstem cholinergic neuronsCat lateral geniculate nucleusInhibitory postsynaptic potentialsReceptor-mediated increaseDistinctive electrophysiological propertiesUnderlying ionic mechanismsLGNd relay cellsAcetylcholine inhibitsCholinergic neuronsAcetylcholine releaseCerebral cortexCholinergic actionCholinergic axonsPostsynaptic potentialsRelay neuronsCholinergic systemFacilitatory influenceElectrophysiological propertiesCat LGNdIntrageniculate interneurons