2024
Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice
Vickers E, McCormick D. Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice. ELife 2024, 13: rp94167. PMID: 38808733, PMCID: PMC11136495, DOI: 10.7554/elife.94167.Peer-Reviewed Original ResearchConceptsTask-specific cognitive demandsNeural activityFlow of neural activityTask-dependent behaviorsRegions of cortexCognitive demandsSensory discriminationMouse dorsalCortical areasBehavior primitivesMesoscopic imagingPopulations of neuronsNeural ensemblesLateral neocortexSimultaneous accessImage dataInternal stateNeuron resolutionNeocortexMiceActivation motifNeuronsSpontaneous changesArousalCortexPan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice
Vickers E, McCormick D. Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice. ELife 2024, 13 DOI: 10.7554/elife.94167.3.Peer-Reviewed Original ResearchTask-specific cognitive demandsNeural activityFlow of neural activityTask-dependent behaviorsRegions of cortexCognitive demandsIn vivo preparationsSensory discriminationMouse dorsalCortical areasPopulations of neuronsBehavior primitivesNeural ensemblesLateral neocortexMesoscopic imagingSimultaneous accessInternal stateNeuron resolutionImage dataNeocortexMiceActivation motifNeuronsSpontaneous changesArousalDecision-making dynamics are predicted by arousal and uninstructed movements
Hulsey D, Zumwalt K, Mazzucato L, McCormick D, Jaramillo S. Decision-making dynamics are predicted by arousal and uninstructed movements. Cell Reports 2024, 43: 113709. PMID: 38280196, PMCID: PMC11016285, DOI: 10.1016/j.celrep.2024.113709.Peer-Reviewed Original ResearchUninstructed movementsStimulus-reward contingenciesTask-performance statesSensory discrimination taskSensory-guided behaviorOptimal performance statesTask performance dataDiscrimination taskTask performanceObservational measuresArousalBehavioral choicesDecision-making dynamicsMarkov modelOptimal performancePupil diameterPerformance stateSub-optimalTaskExternalitiesComputational modelPerformance
2020
Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains
de Gee J, Tsetsos K, Schwabe L, Urai A, McCormick D, McGinley M, Donner T. Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains. ELife 2020, 9: e54014. PMID: 32543372, PMCID: PMC7297536, DOI: 10.7554/elife.54014.Peer-Reviewed Original ResearchConceptsPhasic arousalArousal systemMemory-based decisionsSound detection taskDecision-relevant evidenceBrain arousal systemsChoice biasesChoice biasLiberal biasesDecision domainArousalBehavioral effectsBias suppressionBiasesAmbiguous evidenceRapid dilationSuch decisionsMemoryPupilsTaskDecisionsHumansEvidenceGeneral principlesBias
2015
Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection
McGinley MJ, David SV, McCormick DA. Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection. Neuron 2015, 87: 179-192. PMID: 26074005, PMCID: PMC4631312, DOI: 10.1016/j.neuron.2015.05.038.Peer-Reviewed Original ResearchConceptsCortical neuronsAuditory cortical neuronsSound-evoked responsesSensory-evoked responsesBackground synaptic activityMembrane potentialTonic periodsSignal detection behaviorSynaptic activityStable hyperpolarizationMembrane potential activitySlow oscillationsHippocampal recordingsNeural correlatesNeuronsTask performanceArousalPotential activityDetection behaviorPhysiological signaturesNoise detection taskArousal measuresMiceActivity