2024
Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma.
Shewarega A, Santana J, Nam D, Berz A, Tefera J, Kahl V, Mishra S, Coman D, Duncan J, Roberts S, Wetter A, Madoff D, Chapiro J. Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma. Radiology 2024, 310: e232365. PMID: 38349244, PMCID: PMC10902598, DOI: 10.1148/radiol.232365.Peer-Reviewed Original ResearchConceptsT cell infiltrationCD8<sup>+</sup> T cellsMatrix metalloproteinase inhibitionT cellsHepatocellular carcinomaMatrix metalloproteinase inhibitorsMatrix metalloproteinasesResidual tumorCXCR3<sup>+</sup> CD8<sup>+</sup> T cellsCytotoxic CD8<sup>+</sup> T cell infiltrationIntratumoral CD8+ T cell infiltrationCD8+ T cell infiltrationCD8<sup>+</sup> T cell infiltrationMouse model of hepatocellular carcinomaEarly-stage hepatocellular carcinomaImage-guided tumor ablationUnpaired Student's <i>t</i> testModel of hepatocellular carcinomaFirst-line therapyMurine hepatocellular carcinomaT cell subsetsTumor-associated macrophagesMurine HCC modelLocal immune responseFemale BALB/c mice
2013
Educational Exhibit Abstract No. 393 Future improvements in the role of PET-CT in the assessment of hepatocellular carcinoma, prior to and following the selective internal radiation therapy (SIRT) of Yttrium-90 (Y-90)
Chheang S, Tarlington L, Osborne J, Deh K, Madoff D. Educational Exhibit Abstract No. 393 Future improvements in the role of PET-CT in the assessment of hepatocellular carcinoma, prior to and following the selective internal radiation therapy (SIRT) of Yttrium-90 (Y-90). Journal Of Vascular And Interventional Radiology 2013, 24: s167. DOI: 10.1016/j.jvir.2013.01.422.Peer-Reviewed Original ResearchSelective internal radiation therapyHepatocellular carcinomaNovel PET tracersPET-CTFDG-PETMaximum standardized uptake valuePET tracersNonresectable hepatocellular carcinomaFDG PET-CTStandardized uptake valueInternal radiation therapyPost-treatment evaluationPET-CT imagingY90 radioembolizationConcurrent inflammationResidual tumorMultiple neoplasmsPotential adjunctTreatment outcomesTreatment responseRadiation therapyGI tractNew agentsUptake valueYttrium-90