2022
Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model
Berz AM, Santana JG, Iseke S, Gross M, Pekurovsky V, Laage Gaupp F, Savic LJ, Borde T, Gottwald LA, Boustani AM, Gebauer B, Lin M, Zhang X, Schlachter T, Madoff DC, Chapiro J. Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model. Journal Of Vascular And Interventional Radiology 2022, 33: 764-774.e4. PMID: 35346859, PMCID: PMC9344951, DOI: 10.1016/j.jvir.2022.03.026.Peer-Reviewed Original ResearchConceptsTranscatheter arterial chemoembolizationCytotoxic T-lymphocyte-associated protein 4Rabbit liver tumor modelConventional TACEImmune checkpoint marker expressionLiver tumor modelVX2 rabbit liver tumor modelArterial chemoembolizationBicarbonate infusionImmune responseDifferentiation 3T-lymphocyte-associated protein 4Conventional transcatheter arterial chemoembolizationTumor modelCell death protein 1Marker expressionIntratumoral T cellsImmune checkpoint markersT cell infiltrationDeath protein 1Antigen-presenting cellsImmune cell recruitmentNew Zealand white rabbitsZealand white rabbitsAPC infiltration
2021
Comparison of metabolic and immunologic responses to transarterial chemoembolization with different chemoembolic regimens in a rabbit VX2 liver tumor model
Doemel LA, Santana JG, Savic LJ, Gaupp FML, Borde T, Petukhova-Greenstein A, Kucukkaya AS, Schobert IT, Hamm CA, Gebauer B, Walsh JJ, Rexha I, Hyder F, Lin M, Madoff DC, Schlachter T, Chapiro J, Coman D. Comparison of metabolic and immunologic responses to transarterial chemoembolization with different chemoembolic regimens in a rabbit VX2 liver tumor model. European Radiology 2021, 32: 2437-2447. PMID: 34718844, PMCID: PMC9359419, DOI: 10.1007/s00330-021-08337-3.Peer-Reviewed Original ResearchConceptsDrug-eluting embolicsImmune cell infiltrationAntigen-presenting cellsBicarbonate infusionConventional TACEDEE-TACETransarterial chemotherapyCell infiltrationImmune cellsPeritumoral infiltrationT lymphocytesIntratumoral immune cell infiltrationTumor modelRabbit VX2 liver tumor modelImmunological tumor microenvironmentVX2 liver tumor modelIntra-arterial therapyIntra-arterial treatmentRabbit VX2 tumor modelLiver tumor modelTumor-bearing rabbitsVX2 tumor modelMann-Whitney U testIntratumoral presenceTransarterial chemoembolization
2017
Balloon-Assisted Transarterial Chemoembolization: A Nascent Strategy for the Treatment of Hepatocellular Carcinoma
Kishore S, Cheng W, Smirniotopoulos J, Madoff D. Balloon-Assisted Transarterial Chemoembolization: A Nascent Strategy for the Treatment of Hepatocellular Carcinoma. Digestive Disease Interventions 2017, 01: 115-120. DOI: 10.1055/s-0037-1603961.Peer-Reviewed Original ResearchTransarterial chemoembolizationHepatocellular carcinomaLiver-confined hepatocellular carcinomaTreatment of HCCMajority of patientsBalloon catheter systemCancer-related mortalityLow-profile cathetersConventional transarterial chemoembolizationConventional TACECurative optionTransarterial therapiesLeading causeTherapeutic strategiesMicrocatheter technologyIntratumoral administrationChemotherapeutic agentsPatientsChemoembolizationCarcinomaTreatmentNascent strategyCatheterMajorityTherapy
2014
Interventional Radiology Management of Unresectable Intrahepatic Cholangiocarcinoma
Talenfeld A, Holzwanger D, Madoff D. Interventional Radiology Management of Unresectable Intrahepatic Cholangiocarcinoma. Medical Radiology 2014, 201-223. DOI: 10.1007/978-3-642-40558-7_13.Peer-Reviewed Original ResearchInoperable intrahepatic cholangiocarcinomaTransarterial therapiesTransarterial chemoinfusionTransarterial radioembolizationIntrahepatic cholangiocarcinomaDrug-eluting bead transarterial chemoembolizationYttrium-90 transarterial radioembolizationChild A cirrhosisInterventional radiology managementUnresectable intrahepatic cholangiocarcinomaAbsence of cirrhosisMedian overall survivalLow tumor burdenBead transarterial chemoembolizationLow tumor gradeSmaller tumor sizeNormal performance statusPercutaneous ablative therapiesPercutaneous thermal ablationThermal ablationExtrahepatic diseaseConventional TACEOverall survivalPerformance statusPortal thrombus