Protective and therapeutic role for αB-crystallin in autoimmune demyelination
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De Jager PL, Hafler DA. New Therapeutic Approaches for Multiple Sclerosis. Annual Review Of Medicine 2007, 58: 417-432. PMID: 17217332, DOI: 10.1146/annurev.med.58.071105.111552.Peer-Reviewed Original ResearchConceptsCentral nervous systemMultiple sclerosisNeurodegenerative componentImmunology of MSLarge unmet clinical needSubset of patientsUnderlying pathophysiologic processEffective immunomodulatory treatmentsEntry of lymphocytesNew therapeutic approachesUnmet clinical needCategories of diseaseImmunomodulatory treatmentInflammatory componentCurrent therapiesImmune homeostasisImmune responseIndividual patientsPathophysiologic processesTherapeutic approachesTreatment approachesNervous systemPatientsHealthy profileClinical need