1996
HTLV-I-induced T-cell activation.
Buckle GJ, Hafler DA, Höllsberg P. HTLV-I-induced T-cell activation. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1996, 13 Suppl 1: s107-13. PMID: 8797712, DOI: 10.1097/00042560-199600001-00018.Peer-Reviewed Original ResearchConceptsT cell activationT cellsUninfected T cellsT cell interactionsMyelopathy/tropical spastic paraparesisHuman T-cell lymphotropic virus type ILymphotropic virus type ITropical spastic paraparesisInfected T cellsT cell clonesIL-2 productionInterleukin-2 productionVirus type ISpastic paraparesisSpontaneous proliferationCD28 pathwayGeneralized activationCostimulatory signalsImmune systemSeparate mechanismsHTLVProlonged stateType IActivationCells
1994
Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression.
Höllsberg P, Ausubel LJ, Hafler DA. Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression. The Journal Of Immunology 1994, 153: 566-73. PMID: 8021495, DOI: 10.4049/jimmunol.153.2.566.Peer-Reviewed Original ResearchConceptsT cell clonesT cell activationHuman T-cell lymphotropic virus type ILymphotropic virus type IVirus type ICell activationCell clonesT cellsCD3/TCR complexHTLV-I myelopathyT cell proliferationType IImmune regulationHTLVHyperphosphorylation of pRbProductive infectionCell cycle progressionCell proliferationTCR complexPatientsG1 phaseInfectionSingle cell cloningCycle progressionActivation
1991
The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle
LaSalle J, Hafler D. The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle. Cellular Immunology 1991, 138: 197-206. PMID: 1833074, DOI: 10.1016/0008-8749(91)90144-z.Peer-Reviewed Original ResearchConceptsT cell clonesCell cycleT cellsCD45RA expressionCord bloodTyrosine phosphatase CD45Cell clonesM stageCell cycle stagePHA activationPeripheral blood T cellsCD45RO T cellsCoexpression of CD45RAG2/M stageCD45RA T cellsT cell populationsBlood T cellsG2/M phaseNaive T cellsPhosphatase CD45Propidium iodide stainingHematopoietic cellsM phaseCD45RACD45RO isoform