1999
Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy.
Bieganowska K, Höllsberg P, Buckle G, Lim D, Greten T, Schneck J, Altman J, Jacobson S, Ledis S, Hanchard B, Chin J, Morgan O, Roth P, Hafler D. Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy. The Journal Of Immunology 1999, 162: 1765-71. PMID: 9973440, DOI: 10.4049/jimmunol.162.3.1765.Peer-Reviewed Original ResearchMeSH KeywordsAdultB7-1 AntigenCD28 AntigensCD8-Positive T-LymphocytesFemaleGene Products, taxHLA-A2 AntigenHuman T-lymphotropic virus 1HumansLymphocyte ActivationMaleMiddle AgedParaparesis, Tropical SpasticPeptide FragmentsPhenotypeProtein ConformationReceptors, Antigen, T-Cell, alpha-betaReceptors, ChemokineReceptors, Interleukin-2SolubilityConceptsT cellsIL-2RMHC class I tetramersHuman T-cell lymphotropic virusViral-specific CD8Class I tetramersProgressive neurologic diseaseDifferent chemokine receptorsHLA-A2 alleleCentral nervous systemTCR Vbeta chainsReactive CD8TCR usageInflammatory infiltrateVbeta chainsChemokine receptorsNeurologic diseaseImmune responseCD8Lymphotropic virusMyelopathyNervous systemPatientsHTLVClonal expansion
1995
Tropical spastic paraparesis on the Caribbean coast of Colombia.
Dangond F, Daza JS, Rosania A, Quin MJ, Zaninovic V, Chaplin B, Marlink R, Hafler DA. Tropical spastic paraparesis on the Caribbean coast of Colombia. American Journal Of Tropical Medicine And Hygiene 1995, 52: 155-8. PMID: 7872443, DOI: 10.4269/ajtmh.1995.52.155.Peer-Reviewed Original ResearchConceptsTropical spastic paraparesisSpastic paraparesisHuman T-cell lymphotropic virus type 1Chronic spastic paraparesisProgressive leg weaknessVirus type 1Enzyme-linked immunosorbent assayChronic myelopathySerum positivityLeg weaknessRetroviral diseaseParaparesisType 1Western blotImmunosorbent assayPatientsEthnic originFirst reportMyelopathyDiseaseAntibodies