2008
Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells
De Jager PL, Rossin E, Pyne S, Tamayo P, Ottoboni L, Viglietta V, Weiner M, Soler D, Izmailova E, Faron-Yowe L, O’Brien C, Freeman S, Granados S, Parker A, Roubenoff R, Mesirov JP, Khoury SJ, Hafler DA, Weiner HL. Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain 2008, 131: 1701-1711. PMID: 18567923, PMCID: PMC2730047, DOI: 10.1093/brain/awn118.Peer-Reviewed Original ResearchConceptsRelapsing-remitting MSImmunological profileRRMS subjectsPeripheral bloodUntreated subjectsNatural killer cell profileComprehensive Longitudinal InvestigationAbsence of treatmentCell surface markersCIS subjectsDemyelinating diseaseDemyelination syndromeWomen's HospitalHealthy controlsCytometric profilingCell profilesMonoclonal antibodiesExtension phaseFresh bloodBiomarker discovery effortsDistinct subsetsBloodCell populationsGating strategyHospital
2007
Cytokines and interventional immunology
Hafler D. Cytokines and interventional immunology. Nature Reviews Immunology 2007, 7: 423-423. DOI: 10.1038/nri2101.Peer-Reviewed Original Research
2000
Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population
Anderson D, Bieganowska K, Bar-Or A, Oliveira E, Carreno B, Collins M, Hafler D. Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population. Nature Medicine 2000, 6: 211-214. PMID: 10655112, DOI: 10.1038/72323.Peer-Reviewed Original ResearchConceptsCTLA-4 blockadeT cell populationsCTLA-4T cellsMonoclonal antibodiesB7-1B7-2Immune responseCytotoxic T-lymphocyte antigen-4Whole T cell populationsT-lymphocyte antigen-4Antigen-specific T cellsT cell activation stateHuman T cell populationsT cell functionT cell receptor signalsCo-stimulatory signalsDifferent T cellsT cell stimulationEffect of B7T cell activationActivation stateT cell receptorHuman T cellsFab fragments
1990
FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation
Dang N, Hafler D, Schlossman S, Breitmeyer J. FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation. Cellular Immunology 1990, 125: 42-57. PMID: 2152856, DOI: 10.1016/0008-8749(90)90061-u.Peer-Reviewed Original ResearchConceptsCD3/T cell receptor complexHuman T lymphocyte activationT lymphocyte activationT cellsT cell receptor complexCell receptor complexLymphocyte activationPeripheral blood T cellsMonoclonal antibodiesCytolytic effector functionExogenous IL-2Blood T cellsIL-2 receptorPositive accessory cellsT cell clonesT cell activationReceptor complexHuman T lymphocytesT cell regulatory networkAnti-Ta1Recall antigensPeripheral bloodIL-2T lymphocytesEffector functions
1988
Anti‐CD4 and Anti‐CD2 Monoclonal Antibody Infusions in Subjects with Multiple Sclerosis Immunosuppressive Effects and Human Antimouse Responses
HAFLER D, WEINER H. Anti‐CD4 and Anti‐CD2 Monoclonal Antibody Infusions in Subjects with Multiple Sclerosis Immunosuppressive Effects and Human Antimouse Responses. Annals Of The New York Academy Of Sciences 1988, 540: 557-559. PMID: 2905125, DOI: 10.1111/j.1749-6632.1988.tb27171.x.Peer-Reviewed Original ResearchRegulation of T cell clone function via CD4 and CD8 molecules. Anti-CD4 can mediate two distinct inhibitory activities.
Blue ML, Hafler DA, Daley JF, Levine H, Craig KA, Breitmeyer JB, Schlossman SF. Regulation of T cell clone function via CD4 and CD8 molecules. Anti-CD4 can mediate two distinct inhibitory activities. The Journal Of Immunology 1988, 140: 376-83. PMID: 2891768, DOI: 10.4049/jimmunol.140.2.376.Peer-Reviewed Original ResearchConceptsReceptor functionAnti-CD4Anti-CD8 monoclonal antibodiesCD3-TiCell receptor functionMajor histocompatibility complex moleculesIntracellular free Ca2CD3 T-cell receptorT cell activationHistocompatibility complex moleculesCytotoxic functionT cell receptor functionCD8 moleculesCD4CD8Distinct inhibitory activityCD4 moleculeCell activationAntigen receptor functionCell receptorMonoclonal antibodiesFree Ca2Dependent proliferationFunctional effectsSoluble antibodies
1987
T Cells in Multiple Sclerosis and Inflammatory Central Nervous System Diseases
Hafler D, Weiner H. T Cells in Multiple Sclerosis and Inflammatory Central Nervous System Diseases. Immunological Reviews 1987, 100: 307-332. PMID: 3326824, DOI: 10.1111/j.1600-065x.1987.tb00537.x.Peer-Reviewed Original ResearchConceptsT cellsInflammatory responseCNS tissueInflammatory central nervous system diseasesProgressive multiple sclerosis patientsCentral nervous system diseaseClass II MHC antigensMonoclonal antibodiesT-cell receptor gene rearrangementsCSF T cellsOngoing inflammatory responseTotal T cellsInflammatory CNS diseaseMultiple sclerosis patientsAnti-measles antibodiesAntigen-presenting cellsChronic disease processesAntigen-specific cellsNervous system diseasesReceptor gene rearrangementsMurine monoclonal antibodiesSelective accumulationAlpha beta chainsCNS damageSclerosis patientsIn vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis
Hafler D, Weiner H. In vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis. Annals Of Neurology 1987, 22: 89-93. PMID: 3498435, DOI: 10.1002/ana.410220121.Peer-Reviewed Original ResearchConceptsCentral nervous systemProgressive multiple sclerosisMultiple sclerosisBlood T cellsT cellsCerebrospinal fluidMurine monoclonal antibodiesSheep red blood cell receptorTreatment of MSPeripheral blood T cellsRed blood cell receptorsMonoclonal antibodiesCSF T cellsSerial lumbar puncturesPeripheral immune systemOngoing pathological processAnti-T4MS patientsDaily infusionsLumbar puncturePeripheral bloodInflammatory diseasesCSF specimensNervous systemImmune systemImmunosuppression in progressive multiple sclerosis with high dose intravenous cyclophosphamide and monoclonal antibodies.
Dawson DM, Carter JL, Hafler DA, Weiner HL. Immunosuppression in progressive multiple sclerosis with high dose intravenous cyclophosphamide and monoclonal antibodies. Nuova Rivista Di Neurologia 1987, 57: 88-91. PMID: 3039645.Peer-Reviewed Original ResearchConceptsProgressive multiple sclerosisMonoclonal antibody therapyMultiple sclerosisAntibody therapyChronic progressive multiple sclerosisHigh-dose intravenous cyclophosphamideMultiple sclerosis patientsForm of treatmentLong-term controlIntravenous cyclophosphamideSclerosis patientsClinical resultsSerious toxicityImmune parametersPilot trialCyclophosphamideNervous systemSclerosisTerm controlsPatientsMonoclonal antibodiesACTHOnly small numbersTherapyAdverse effects
1984
Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes
Tardieu M, Powers M, Hafler D, Hauser S, Weiner H. Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes. European Journal Of Immunology 1984, 14: 561-565. PMID: 6329771, DOI: 10.1002/eji.1830140614.Peer-Reviewed Original ResearchConceptsNormal tissuesMonoclonal antibodiesViral infectionOnly virusInfection of miceUninfected control animalsAdult C57BL/6 miceAutoreactive monoclonal antibodiesNS1 myeloma cellsReovirus type 3Reovirus type 1Autoimmune responseC57BL/6 miceLung tissueT lymphocytesImmune responseSplenic lymphocytesControl animalsEpendymal cellsViral determinantsMyeloma cellsType 1LymphocytesInfectionReovirus type