1997
Glomerular epithelial cell products stimulate mesangial cell proliferation in culture
Budde K, Neumayer H, Salant D, Cybulsky A, Coleman D, Sterzel R. Glomerular epithelial cell products stimulate mesangial cell proliferation in culture. Kidney International 1997, 52: 733-741. PMID: 9291194, DOI: 10.1038/ki.1997.389.Peer-Reviewed Original ResearchConceptsGlomerular epithelial cellsMC growth factorsMesangial cellsGlomerular diseaseGrowth factorMesangial cell proliferationEpithelial cell productsQuiescent rat mesangial cellsRat mesangial cellsIL-6IL-4IL-5TNF-alphaIL-2Glomerular cell typesIL-1GM-CSFTGF betaSoluble factorsProliferative activityCell productsCompetitive binding assaysEpithelial cellsMitogenic activityCell proliferation
1992
Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity
Rupprecht H, Dann P, Sukhatme V, Sterzel R, Coleman D. Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity. American Journal Of Physiology 1992, 263: f623-f636. PMID: 1415734, DOI: 10.1152/ajprenal.1992.263.4.f623.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsArginine VasopressinDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGlomerular MesangiumImmediate-Early ProteinsMaleMitogensPlatelet-Derived Growth FactorProtein Kinase CRatsRats, Sprague-DawleyRNA, MessengerSerotoninTime FactorsTranscription FactorsVasoconstrictionVasodilation
1990
Interleukin 6 is an autocrine growth factor for mesangial cells
Ruef C, Budde K, Lacy J, Northemann W, Baumann M, Sterzel R, Coleman D. Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney International 1990, 38: 249-257. PMID: 2402117, DOI: 10.1038/ki.1990.193.Peer-Reviewed Original ResearchConceptsIL-6Autocrine growth factorInterleukin-6T cellsGrowth factorSecrete IL-6Possible paracrine roleAcute phase responseIL-6 mRNADose-dependent increaseIL-6 actsMesangial cell proliferationIL-6 resultsGlomerular inflammationNumber of MCsImmune responseRat MCsParacrine roleB cellsMesangial cellsMC-CMEndothelial cellsAutocrine signalsCell proliferationPlasmacytoma cellsRat Tracheal Epithelial Cells Produce Granulocyte/Macrophage Colony-stimulating Factor
Smith S, Lee D, Lacy J, Coleman D. Rat Tracheal Epithelial Cells Produce Granulocyte/Macrophage Colony-stimulating Factor. American Journal Of Respiratory Cell And Molecular Biology 1990, 2: 59-68. PMID: 2407273, DOI: 10.1165/ajrcmb/2.1.59.Peer-Reviewed Original ResearchAnimalsAntibodiesCells, CulturedChromatography, High Pressure LiquidColony-Stimulating FactorsCulture MediaDNA ProbesEpithelial CellsEpitheliumGranulocyte-Macrophage Colony-Stimulating FactorGrowth SubstancesLipopolysaccharidesMaleMolecular WeightNucleic Acid HybridizationRatsRats, Inbred F344TracheaTranscription, Genetic
1989
Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor
Budde K, Coleman D, Lacy J, Sterzel R. Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor. American Journal Of Physiology 1989, 257: f1065-f1078. PMID: 2690641, DOI: 10.1152/ajprenal.1989.257.6.f1065.Peer-Reviewed Original ResearchConceptsRat mesangial cellsGranulocyte-macrophage colony-stimulating factorCultured rat mesangial cellsMesangial cellsColony-stimulating factorGM-CSFMC-CMGlomerular mesangial cellsPeritoneal MPsEffector cellsIL-2Inflammatory processGlomerular diseaseInterleukin-2T cellsT lymphocytesInterleukin-4Murine GM-CSFRenal glomeruliSerum-free conditionsSoluble factorsProliferative activitySpecific cDNA probesGM-CSF mRNA transcriptsPresent findings