1999
Constitutive Calcium-independent Release of Toxoplasma gondii Dense Granules Occurs through the NSF/SNAP/SNARE/Rab Machinery*
Chaturvedi S, Qi H, Coleman D, Rodriguez A, Hanson P, Striepen B, Roos D, Joiner K. Constitutive Calcium-independent Release of Toxoplasma gondii Dense Granules Occurs through the NSF/SNAP/SNARE/Rab Machinery*. Journal Of Biological Chemistry 1999, 274: 2424-2431. PMID: 9891012, DOI: 10.1074/jbc.274.4.2424.Peer-Reviewed Original ResearchConceptsN-ethylmaleimide-sensitive fusion proteinDense matrix granulesDense granulesBeta-lactamase secretionMammalian homologueDissociation inhibitorAbsence of ATPPathogenic protozoan parasitesCalcium-independent fashionPermeabilized parasitesFusion proteinProtein componentsProtozoan parasiteCalcium-independent releaseDense granule releaseParasitesMachineryProteinN-ethylmaleimideGuanosine 5'Matrix granulesGranule releaseToxoplasma gondiiGranulesHomologues
1997
Glomerular epithelial cell products stimulate mesangial cell proliferation in culture
Budde K, Neumayer H, Salant D, Cybulsky A, Coleman D, Sterzel R. Glomerular epithelial cell products stimulate mesangial cell proliferation in culture. Kidney International 1997, 52: 733-741. PMID: 9291194, DOI: 10.1038/ki.1997.389.Peer-Reviewed Original ResearchConceptsGlomerular epithelial cellsMC growth factorsMesangial cellsGlomerular diseaseGrowth factorMesangial cell proliferationEpithelial cell productsQuiescent rat mesangial cellsRat mesangial cellsIL-6IL-4IL-5TNF-alphaIL-2Glomerular cell typesIL-1GM-CSFTGF betaSoluble factorsProliferative activityCell productsCompetitive binding assaysEpithelial cellsMitogenic activityCell proliferation
1994
Serum response elements mediate protein kinase C dependent transcriptional induction of early growth response gene‐1 by arginine vasopressin in rat mesangial cells
Rupprecht H, Sukhatme V, Rupprecht A, Sterzel R, Coleman D. Serum response elements mediate protein kinase C dependent transcriptional induction of early growth response gene‐1 by arginine vasopressin in rat mesangial cells. Journal Of Cellular Physiology 1994, 159: 311-323. PMID: 8163570, DOI: 10.1002/jcp.1041590214.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArginine VasopressinBase SequenceBloodDNA-Binding ProteinsEarly Growth Response Protein 1Enzyme ActivationGene Expression RegulationGlomerular MesangiumHalf-LifeImmediate-Early ProteinsMolecular Sequence DataPromoter Regions, GeneticProtein Kinase CRatsRNA, MessengerTranscription FactorsTranscription, GeneticConceptsEarly growth response gene-1Transcriptional inductionResponse gene-1Egr-1Gene 1Electrophoretic mobility shift assaysDependent transcriptional inductionDNA-protein interactionsPromoter deletion analysisMobility shift assaysIntracellular biochemical eventsProtein kinase CInduction of mitogenesisMesangial cellsEarly gene expressionExtracellular matrix productionDeletion analysisPK CShift assaysTranscriptional levelAVP stimulationHeterologous promoterConsensus sequenceGene expressionPromoter activityAnalysis of Egr-1 protein induction in murine peritoneal macrophages treated with granulocyte-macrophage colony-stimulating factor.
Li C, Mitchell D, Coleman D. Analysis of Egr-1 protein induction in murine peritoneal macrophages treated with granulocyte-macrophage colony-stimulating factor. The Yale Journal Of Biology And Medicine 1994, 67: 269-76. PMID: 8579643, PMCID: PMC2588905.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBlotting, WesternCell DivisionDNA-Binding ProteinsDose-Response Relationship, DrugEarly Growth Response Protein 1Granulocyte-Macrophage Colony-Stimulating FactorImmediate-Early ProteinsMacrophages, PeritonealMiceMolecular Sequence DataThioglycolatesTranscription FactorsConceptsEgr-1 proteinMurine peritoneal macrophagesEarly growth response gene-1Macrophage proliferationGranulocyte-macrophage colony-stimulating factorResponse gene-1Egr-1 mRNAProtein speciesColony-stimulating factorGM-CSFPathogen invasionWestern blot analysisGene 1Stimulation of macrophagesMacrophage differentiationPeritoneal macrophagesProtein inductionProteinBlot analysisTranscriptionProliferationGM-CSF inductionInductionMacrophagesPhysiologic circumstances
1993
PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements
Rupprecht H, Sukhatme V, Lacy J, Sterzel R, Coleman D. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. American Journal Of Physiology 1993, 265: f351-f360. PMID: 8214093, DOI: 10.1152/ajprenal.1993.265.3.f351.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDNA-Binding ProteinsEarly Growth Response Protein 1Gene ExpressionGlomerular MesangiumImmediate-Early ProteinsMolecular Sequence DataNuclear ProteinsOligonucleotide ProbesPhosphorylationPlatelet-Derived Growth FactorPromoter Regions, GeneticRatsSerum Response FactorTranscription FactorsTranscription, GeneticTyrosineConceptsPlatelet-derived growth factorPDGF stimulationElectrophoretic mobility shift assaysNuclear run-off assaysPromoter deletion analysisEgr-1 transcriptionEarly growth response gene-1Serum response elementUpstream serum response elementsProtein tyrosine phosphorylationMobility shift assaysRun-off assaysResponse gene-1Egr-1 inductionEgr-1 mRNAEgr-1 expressionImmediate early genesTranscriptional inductionDeletion analysisTyrosine phosphorylationShift assaysTranscriptional levelConsensus sequenceTranscription rateGene expression
1992
Lipopolysaccharide induces Egr-1 mRNA and protein in murine peritoneal macrophages.
Coleman D, Bartiss A, Sukhatme V, Liu J, Rupprecht H. Lipopolysaccharide induces Egr-1 mRNA and protein in murine peritoneal macrophages. The Journal Of Immunology 1992, 149: 3045-51. PMID: 1401930, DOI: 10.4049/jimmunol.149.9.3045.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell DivisionDNA-Binding ProteinsDose-Response Relationship, ImmunologicEarly Growth Response Protein 1Hydrogen PeroxideImmediate-Early ProteinsImmunity, CellularLipopolysaccharidesMacrophagesMiceMice, Inbred BALB CMolecular Sequence DataPeritoneal CavityProtein Kinase CRNA, MessengerTetradecanoylphorbol AcetateTime FactorsTranscription FactorsTranscription, GeneticTranscriptional ActivationZinc FingersEffect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity
Rupprecht H, Dann P, Sukhatme V, Sterzel R, Coleman D. Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity. American Journal Of Physiology 1992, 263: f623-f636. PMID: 1415734, DOI: 10.1152/ajprenal.1992.263.4.f623.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsArginine VasopressinDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGlomerular MesangiumImmediate-Early ProteinsMaleMitogensPlatelet-Derived Growth FactorProtein Kinase CRatsRats, Sprague-DawleyRNA, MessengerSerotoninTime FactorsTranscription FactorsVasoconstrictionVasodilationMesangial cell-matrix interactions. Effects on mesangial cell growth and cytokine secretion.
Ruef C, Kashgarian M, Coleman D. Mesangial cell-matrix interactions. Effects on mesangial cell growth and cytokine secretion. American Journal Of Pathology 1992, 141: 429-39. PMID: 1323220, PMCID: PMC1886618.Peer-Reviewed Original ResearchConceptsIL-6 secretionInterleukin-6Mesangial cellsCytokine secretionMC growthIL-6 releaseIL-1 alphaMesangial cell growthDose-dependent mannerMesangioproliferative GNInflammatory mediatorsInflammatory cellsTNF-alphaCollagen type IVCollagen type ISecretionColl IType IVExtracellular matrix proteinsProliferative phenotypeCytokinesType ICell growthMatrix proteinsCellsInterleukin-6: An autocrine regulator of mesangial cell growth
Coleman D, Ruef C. Interleukin-6: An autocrine regulator of mesangial cell growth. Kidney International 1992, 41: 604-606. PMID: 1573836, DOI: 10.1038/ki.1992.91.Peer-Reviewed Original ResearchConceptsInterleukin-6Transgenic miceVivo studiesTransgenic mouse modelMesangial cell growthIL-6 geneGranulocyte-macrophage colonyIgG1 plasmacytosisCytokine productionImmune cellsMesangioproliferative glomerulonephritisInterleukin-1Autocrine regulatorMouse modelGlomerular cellsCell culture modelProliferative effectTarget cellsTissue distributionImmunoglobulin heavy chain enhancerChain enhancerTissue cellsCulture modelMiceNontransformed cell types
1991
Transfection of adherent murine peritoneal macrophages with a reporter gene using DEAE-dextran
Rupprecht A, Coleman D. Transfection of adherent murine peritoneal macrophages with a reporter gene using DEAE-dextran. Journal Of Immunological Methods 1991, 144: 157-163. PMID: 1960412, DOI: 10.1016/0022-1759(91)90082-q.Peer-Reviewed Original ResearchConceptsReporter geneMurine peritoneal macrophagesBacterial chloramphenicol acetyl transferase (CAT) reporter geneChloramphenicol acetyl transferase (CAT) reporter geneAcetyl transferase reporter geneCAT reporter geneHeterologous plasmid DNAEukaryotic expression vectorReporter gene assayThioglycollate-elicited murine peritoneal macrophagesCAT activityHigher CAT activityTransfection of macrophagesGene regulationPeritoneal macrophagesPrimary culturesExpression vectorPrimary macrophage culturesGene assayTransfection strategyGenesTransfectionDEAE-dextranAdherent macrophagesPlasmid DNA
1990
Interleukin 6 is an autocrine growth factor for mesangial cells
Ruef C, Budde K, Lacy J, Northemann W, Baumann M, Sterzel R, Coleman D. Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney International 1990, 38: 249-257. PMID: 2402117, DOI: 10.1038/ki.1990.193.Peer-Reviewed Original ResearchConceptsIL-6Autocrine growth factorInterleukin-6T cellsGrowth factorSecrete IL-6Possible paracrine roleAcute phase responseIL-6 mRNADose-dependent increaseIL-6 actsMesangial cell proliferationIL-6 resultsGlomerular inflammationNumber of MCsImmune responseRat MCsParacrine roleB cellsMesangial cellsMC-CMEndothelial cellsAutocrine signalsCell proliferationPlasmacytoma cellsMacrophage colony-stimulating factor production by murine and human keratinocytes. Enhancement by bacterial lipopolysaccharide.
Chodakewitz J, Lacy J, Edwards S, Birchall N, Coleman D. Macrophage colony-stimulating factor production by murine and human keratinocytes. Enhancement by bacterial lipopolysaccharide. The Journal Of Immunology 1990, 144: 2190-6. PMID: 2179407, DOI: 10.4049/jimmunol.144.6.2190.Peer-Reviewed Original ResearchRat Tracheal Epithelial Cells Produce Granulocyte/Macrophage Colony-stimulating Factor
Smith S, Lee D, Lacy J, Coleman D. Rat Tracheal Epithelial Cells Produce Granulocyte/Macrophage Colony-stimulating Factor. American Journal Of Respiratory Cell And Molecular Biology 1990, 2: 59-68. PMID: 2407273, DOI: 10.1165/ajrcmb/2.1.59.Peer-Reviewed Original ResearchAnimalsAntibodiesCells, CulturedChromatography, High Pressure LiquidColony-Stimulating FactorsCulture MediaDNA ProbesEpithelial CellsEpitheliumGranulocyte-Macrophage Colony-Stimulating FactorGrowth SubstancesLipopolysaccharidesMaleMolecular WeightNucleic Acid HybridizationRatsRats, Inbred F344TracheaTranscription, Genetic
1989
Recombinant granulocyte-macrophage colony-stimulating factor increases adenylate cyclase activity in murine peritoneal macrophages.
Coleman D, Liu J, Bartiss A. Recombinant granulocyte-macrophage colony-stimulating factor increases adenylate cyclase activity in murine peritoneal macrophages. The Journal Of Immunology 1989, 143: 4134-40. PMID: 2687376, DOI: 10.4049/jimmunol.143.12.4134.Peer-Reviewed Original ResearchRat mesangial cells produce granulocyte-macrophage colony-stimulating factor
Budde K, Coleman D, Lacy J, Sterzel R. Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor. American Journal Of Physiology 1989, 257: f1065-f1078. PMID: 2690641, DOI: 10.1152/ajprenal.1989.257.6.f1065.Peer-Reviewed Original ResearchConceptsRat mesangial cellsGranulocyte-macrophage colony-stimulating factorCultured rat mesangial cellsMesangial cellsColony-stimulating factorGM-CSFMC-CMGlomerular mesangial cellsPeritoneal MPsEffector cellsIL-2Inflammatory processGlomerular diseaseInterleukin-2T cellsT lymphocytesInterleukin-4Murine GM-CSFRenal glomeruliSerum-free conditionsSoluble factorsProliferative activitySpecific cDNA probesGM-CSF mRNA transcriptsPresent findingsParathyroid hormone and lipopolysaccharide induce murine osteoblast-like cells to secrete a cytokine indistinguishable from granulocyte-macrophage colony-stimulating factor.
Horowitz M, Coleman D, Flood P, Kupper T, Jilka R. Parathyroid hormone and lipopolysaccharide induce murine osteoblast-like cells to secrete a cytokine indistinguishable from granulocyte-macrophage colony-stimulating factor. Journal Of Clinical Investigation 1989, 83: 149-157. PMID: 2642917, PMCID: PMC303655, DOI: 10.1172/jci113852.Peer-Reviewed Original ResearchConceptsParathyroid hormoneGranulocyte-macrophage colony-stimulating factorColony-stimulating factorOsteoclast activityDose of PTHGM-CSFNumber of osteoclastsSecretion of cytokinesBone active agentsUnknown cytokinesSpecific cytokinesCytokinesCulture resultsPrimary murine osteoblastsActive inductionLipopolysaccharideSecretion of collagenSecretionSerological techniquesNew boneMurine osteoblastsHormone
1988
Hematopoietic, Lymphopoietic, and Proinflammatory Cytokines Produced by Human and Murine Keratinocytes
KUPPER T, HOROWITZ M, BIRCHALL N, MIZUTANI H, COLEMAN D, McGUIRE J, FLOOD P, DOWER S, LEE F. Hematopoietic, Lymphopoietic, and Proinflammatory Cytokines Produced by Human and Murine Keratinocytes. Annals Of The New York Academy Of Sciences 1988, 548: 262-270. PMID: 2470299, DOI: 10.1111/j.1749-6632.1988.tb18814.x.Peer-Reviewed Original ResearchGranulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophages.
Coleman D, Chodakewitz J, Bartiss A, Mellors J. Granulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophages. Blood 1988, 72: 573-8. PMID: 3042043, DOI: 10.1182/blood.v72.2.573.bloodjournal722573.Peer-Reviewed Original ResearchConceptsFc-dependent phagocytosisAnti-Toxoplasma activityGranulocyte-macrophage colony-stimulating factorGM-CSFColony-stimulating factorTissue-derived macrophagesRecombinant GM-CSFClass II major histocompatibility antigensMacrophage oxidative metabolismMajor histocompatibility antigensSite of exposureGM-CSF antibodyMurine recombinant GM-CSFThioglycollate-elicited cellsPhorbol myristate acetateNeutrophil functionHistocompatibility antigensEffector functionsVariety of cellsFunctional capacityMacrophage functionThioglycollate-elicited macrophagesResident macrophagesPeritoneal macrophagesStimulatory effectKeratinocyte-derived granulocyte/macrophage colony-stimulating factor induces DNA synthesis by peritoneal macrophages.
Chodakewitz J, Kupper T, Coleman D. Keratinocyte-derived granulocyte/macrophage colony-stimulating factor induces DNA synthesis by peritoneal macrophages. The Journal Of Immunology 1988, 140: 832-6. PMID: 3257506, DOI: 10.4049/jimmunol.140.3.832.Peer-Reviewed Original Research
1987
Stimulation of macrophage H2O2 release by resident thymocytes: Effect of a soluble factor distinct from interferon-γ
Mellors J, Bartiss A, Coleman D. Stimulation of macrophage H2O2 release by resident thymocytes: Effect of a soluble factor distinct from interferon-γ. Cellular Immunology 1987, 110: 391-399. PMID: 3121188, DOI: 10.1016/0008-8749(87)90131-6.Peer-Reviewed Original ResearchConceptsT cellsResident thymocytesAntigen-specific immune responsesSoluble factorsMacrophage microbicidal mechanismsRespiratory burst capacityLow molecular weight soluble factorMacrophage oxidative metabolismNonactivated T cellsMacrophage H2O2 releaseActivated T cellsMacrophage effector functionsEnzyme-linked immunosorbentReceptor-mediated phagocytosisImmune responseIFN-gammaEffector functionsToxoplasma gondiiControl macrophagesRespiratory burstMicrobicidal mechanismsPeritoneal macrophagesInterferon activityMacrophagesBurst capacity