1997
Glomerular epithelial cell products stimulate mesangial cell proliferation in culture
Budde K, Neumayer H, Salant D, Cybulsky A, Coleman D, Sterzel R. Glomerular epithelial cell products stimulate mesangial cell proliferation in culture. Kidney International 1997, 52: 733-741. PMID: 9291194, DOI: 10.1038/ki.1997.389.Peer-Reviewed Original ResearchConceptsGlomerular epithelial cellsMC growth factorsMesangial cellsGlomerular diseaseGrowth factorMesangial cell proliferationEpithelial cell productsQuiescent rat mesangial cellsRat mesangial cellsIL-6IL-4IL-5TNF-alphaIL-2Glomerular cell typesIL-1GM-CSFTGF betaSoluble factorsProliferative activityCell productsCompetitive binding assaysEpithelial cellsMitogenic activityCell proliferation
1990
Interleukin 6 is an autocrine growth factor for mesangial cells
Ruef C, Budde K, Lacy J, Northemann W, Baumann M, Sterzel R, Coleman D. Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney International 1990, 38: 249-257. PMID: 2402117, DOI: 10.1038/ki.1990.193.Peer-Reviewed Original ResearchConceptsIL-6Autocrine growth factorInterleukin-6T cellsGrowth factorSecrete IL-6Possible paracrine roleAcute phase responseIL-6 mRNADose-dependent increaseIL-6 actsMesangial cell proliferationIL-6 resultsGlomerular inflammationNumber of MCsImmune responseRat MCsParacrine roleB cellsMesangial cellsMC-CMEndothelial cellsAutocrine signalsCell proliferationPlasmacytoma cells
1988
Keratinocyte Derived T-Cell Growth Factor (KTGF) Is Identical to Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)
Kupper T, Lee F, Coleman D, Chodakewitz J, Flood P, Horowitz M. Keratinocyte Derived T-Cell Growth Factor (KTGF) Is Identical to Granulocyte Macrophage Colony Stimulating Factor (GM-CSF). Journal Of Investigative Dermatology 1988, 91: 185-188. PMID: 3294304, DOI: 10.1111/1523-1747.ep12464470.Peer-Reviewed Original ResearchConceptsS1 nuclease analysisCell linesMurine T cell lineVariety of biochemicalsGrowth factorMurine GM-CSF cDNAGM-CSFNuclease analysisCultured neonatal keratinocytesGM-CSF cDNARecombinant murine GM-CSFMurine GM-CSFKeratinocyte cell lineT-cell activating propertiesT cell growth factorMacrophage-colony stimulating factorT cell linesGranulocyte macrophage-colony stimulating factorImmunochemical criteriaHigh specific activityProliferationSpecific activityColony-Stimulating FactorHT-2 cellsPam 212
1986
Keratinocyte-derived T-cell growth factor: a T-cell growth factor functionally distinct from interleukin 2.
Kupper T, Coleman D, McGuire J, Goldminz D, Horowitz M. Keratinocyte-derived T-cell growth factor: a T-cell growth factor functionally distinct from interleukin 2. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 4451-4455. PMID: 3520573, PMCID: PMC323751, DOI: 10.1073/pnas.83.12.4451.Peer-Reviewed Original ResearchConceptsT cell growth factorIL-2-dependent cell lineT cellsT lymphocytesGrowth factorInterleukin-2Trophic factorsIL-2-dependent cell line HT-2Cell linesCertain dermatologic disordersConventional IL-2IL-2-dependent T cell lineActivated T lymphocytesIL-2 preparationsMicroenvironment of skinT cell linesGel-filtration HPLC analysisDermatologic disordersIL-2CTLL-2 cellsPreferential proliferationLymphocytesEpithelial cellsEpidermal epithelial cellsDifferential effects