2015
Dead enzymes in the aldehyde dehydrogenase gene family: role in drug metabolism and toxicology
Jackson BC, Thompson DC, Charkoftaki G, Vasiliou V. Dead enzymes in the aldehyde dehydrogenase gene family: role in drug metabolism and toxicology. Expert Opinion On Drug Metabolism & Toxicology 2015, 11: 1839-1847. PMID: 26558415, PMCID: PMC4937717, DOI: 10.1517/17425255.2016.1108406.Peer-Reviewed Original ResearchConceptsAldehyde dehydrogenase gene familiesDehydrogenase gene familyDead enzymesGene familyActive enzymeProtein-protein interactionsTotal enzyme populationNon-enzymatic functionsALDH proteinsAvailability of substratesSubcellular spaceGene productsKey residuesProtein recordsCatalytic activityEnzyme populationPathophysiological functionsAllosteric modulationEnzymeBiological actionsProteinBiological activityComputational analysisALDHFamily
2013
Glutathione defense mechanism in liver injury: Insights from animal models
Chen Y, Dong H, Thompson DC, Shertzer HG, Nebert DW, Vasiliou V. Glutathione defense mechanism in liver injury: Insights from animal models. Food And Chemical Toxicology 2013, 60: 38-44. PMID: 23856494, PMCID: PMC3801188, DOI: 10.1016/j.fct.2013.07.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLiver injuryGlutamate-cysteine ligaseMouse modelLiver disease processTransgenic mouse modelCellular GSH concentrationGSH homeostasisLiver diseaseClinical stageHepatic insultLiver pathologyDisease processRate-limiting enzymeAnimal modelsHepatic GSHHepatic responseModifier subunitGenetic deficiencyInjuryPathophysiological functionsGSH deficitThiol antioxidantGSH concentrationMiceRole of GSH