2018
Chronic Complications of Cholestasis Evaluation and Management
Assis DN. Chronic Complications of Cholestasis Evaluation and Management. Clinics In Liver Disease 2018, 22: 533-544. PMID: 30259851, DOI: 10.1016/j.cld.2018.03.014.BooksMeSH KeywordsAbsorptiometry, PhotonAvitaminosisBone Density Conservation AgentsBone Diseases, MetabolicCarcinoma, HepatocellularCholestasisDiet, HealthyEarly Detection of CancerEsophageal and Gastric VaricesExerciseFibric AcidsGastrointestinal HemorrhageHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemiasHypertension, PortalLiver Cirrhosis, BiliaryLiver NeoplasmsMass ScreeningOsteoporosisOsteoporotic FracturesVitamin A DeficiencyVitamin D DeficiencyVitamin E DeficiencyVitamin K DeficiencyConceptsPrimary biliary cholangitisChronic cholestasisFat-soluble vitamin deficiencyEarly-stage diseaseMetabolic bone diseaseCardiovascular eventsChronic complicationsPortal hypertensionBiliary cholangitisVitamin deficiencyBone diseaseLong-term effectsNotable riskCholestasisComplicationsPatientsPractical managementDiseaseRiskHarmful consequencesCholangitisHypertensionHyperlipidemiaOsteoporosisTherapy
2015
Fibrates and cholestasis
Ghonem NS, Assis DN, Boyer JL. Fibrates and cholestasis. Hepatology 2015, 62: 635-643. PMID: 25678132, PMCID: PMC4515188, DOI: 10.1002/hep.27744.BooksConceptsPrimary sclerosing cholangitisPrimary biliary cirrhosisCholestatic liver diseaseUDCA therapyLiver diseaseUrsodeoxycholic acidNuclear receptorsProgression of PBCHepatic transportersPeroxisome proliferator-activated receptor alphaProliferator-activated receptor alphaToxic bile constituentsApical sodium-dependent bile salt transporterOnly therapeutic optionCholestatic liver disordersBile acid homeostasisBile acid synthesisBile salt transportersMultidrug resistance protein 3Cytochrome P450PPARα effectLiver transplantationSclerosing cholangitisBiliary cirrhosisLiver failure