2022
Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis
Alrabadi LS, Dutton A, Rabiee A, Roberts SJ, Deng Y, Cusack L, Silveira MG, Ciarleglio M, Bucala R, Sinha R, Boyer JL, Assis DN. Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis. JHEP Reports 2022, 4: 100450. PMID: 35434588, PMCID: PMC9011026, DOI: 10.1016/j.jhepr.2022.100450.Peer-Reviewed Original ResearchQuality of lifeMindfulness-based stress reductionInflammatory cytokine levelsDisease activityCytokine levelsAutoimmune hepatitisAlanine aminotransferaseAdult patientsTRIAL REGISTRATIONPeripheral blood cytokine levelsScore improvementMBSR programPilot studyBlood cytokine levelsSerum alanine aminotransferaseClinical trial registrationSignificant dose reductionPerceived stressExploratory pilot studyALT levelsSteroid requirementsStress reductionCytokine mediatorsALT reductionMedication needs
2016
A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients
Assis DN, Takahashi H, Leng L, Zeniya M, Boyer JL, Bucala R. A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients. Digestive Diseases And Sciences 2016, 61: 3506-3512. PMID: 27696094, PMCID: PMC5106299, DOI: 10.1007/s10620-016-4322-z.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAdultAlanine TransaminaseAntigens, Differentiation, B-LymphocyteAsian PeopleCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleGenetic Predisposition to DiseaseHepatitis, AutoimmuneHistocompatibility Antigens Class IIHumansIntramolecular OxidoreductasesJapanMacrophage Migration-Inhibitory FactorsMaleMiddle AgedPolymorphism, GeneticPolymorphism, Single NucleotideSeverity of Illness IndexUnited StatesConceptsMacrophage migration inhibitory factorAIH patientsAutoimmune hepatitisSteroid requirementsMIF expressionMacrophage Migration Inhibitory Factor PolymorphismGC/CC genotypesCC/GCJapanese AIH patientsJapanese patient groupMigration inhibitory factorMultiple autoimmune diseasesGC single nucleotide polymorphismsGC/CCAIH groupHepatitis severityMIF promoterSteroid resistanceMIF genotypeSerum ALTSymptomatic presentationGG patientsHigher ALTClinical parametersMIF polymorphisms